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226 Kestle, John R. W.; Brockmeyer, Douglas LeeOutcomes after decompressive craniectomy for severe traumatic brain injury in childrenObject. Severe traumatic brain injury (TBI) is often accompanied by early death due to transtentorial herniation. Decompressive craniectomy, performed alone or in conjunction with evacuation of the mass lesion, can reduce the incidence of raised intracranial pressure (ICP). In this paper the authors...Traumatic brain injury; Decompressive craniectomy; Pediatric neurosurgery2006
227 Digre, Kathleen B.; Couldwell, William T.; Amini, AminPhotophobia in a blind patient: An alternate visual pathway. Case report.Photophobia is a common neurological and ophthalmological symptom that has been associated with a growing number of neurosurgical conditions, especially compressive lesions. The exact signaling pathways and neurophysiological features of the disorder are not well understood; however, data from multi...Photophobia, Blindness, Signaling Pathway, Pretectal Nuclei, Trigeminal Pathway2006-12-14
228 Couldwell, William T.; Jensen, Randy L.; Gillespie, David L.Celecoxib inhibits meningioma tumor growth in a mouse xenograft modelBackground: Treatments for recurrent meningiomas are limited. We previously demonstrated universal expression of COX-2 in meningiomas and dose-dependent growth inhibition in vitro with celecoxib, a COX-2 inhibitor. We therefore tested the effects of celecoxib on meningioma growth in a mouse xenograf...Meningioma; Cyclooxygenase-2; COX-2; Celecoxib2007
229 Couldwell, William T.Management of cysticercosis cerebriInfestation of the central nervous system (CNS) with the parasitic larval form of the cestode Taenia solium, Cysticercosis Cerebri represents an endemic problem in much of the underdeveloped world. In such areas, up to 4% of the population maybe affected by neurocysticercosis, and it accounts for u...Taenia solium; Cysticercosis Cerebri; Parenchymal cyst; Basilar cisternal cyst; Intraventricular cyst1989
230 Schmidt, Meic H.Syndrome of inappropriate secretion of antidiuretic hormone and hyponatremia after spinal surgeryHyponatremia caused by an inappropriately high level of antidiuretic hormone secretion after spinal surgery is an uncommon and self-limiting phenomenon that resolves within 2 or 3 weeks. During the early postoperative period, the patient's urine output and serum level of sodium should be monitored ...Syndrome of inappropriate antidiuretic hormone secretion; SIADH; Hyponatremia; Spinal surger2004
231 Couldwell, William T.; Nelson, Don HarryNelson syndrome: historical perspectives and current conceptsThe appearance of an adrenocorticotropic hormone (ACTH)-producing tumor after bilateral adrenalectomy for Cushing disease was first described by Nelson in 1958. The syndrome that now bears his name was characterized by hyperpigmentation, a sellar mass, and increased plasma ACTH levels. The treatment...2007-01-01
232 Kestle, John R. W.; Brockmeyer, Douglas LeeCranial base strategies for resection of craniopharyngioma in childrenThe optimal treatment of craniopharyngioma in children remains a challenge. The use of complete excision to minimize recurrence continues to be controversial because of the risk of postoperative morbidity and death. Advances in skull base approaches, modern microsurgical techniques, neuroimaging, an...Craniopharyngioma; Surgical approach; Skull base surgery2005
233 Couldwell, William T.Recurrent infrasellar clival craniopharyngiomaThe patient is a 44-year-old man who underwent resection of a posterior nasopharynx tumor 12 years earlier via left lateral rhinotomy approach. The final pathological analysis indicated the tumor was a craniopharyngioma, and the patient subsequently underwent focal radiation. The patient returned t...Ectopic Craniopharyngioma; Recurrence; Infrasellar; Clivus2007
234 Couldwell, William T.Comment on Wong, H. T., et al.: Comparative impact of video consultation on emergency neurosurgical referralsThe Author's explored the facility and accuracy of telephone, teleradiology, or video consultation between a large general hospital and their tertiary neurosurgical center. Although there was increased diagnostic accuracy with video consultation or teleradiology, they note that consultation via vid...Teleradiology; Video consultation; Neurosurgical referrals2006
235 Couldwell, William T.Transfacet pedicle-sparing approach for thoracic disc removal: cadaveric morphometric analysis and preliminary clinical experienceA number of operative techniques have been described for the treatment of herniated thoracic discs. The transfacet pedicle-sparing approach allows for complete disc removal with limited spinal column disruption and soft-tissue dissection. Fifteen cadaveric spinal columns were used for evaluation of...Thoracic spine; Herniated thoracic discs; Intervertebral disc herniation; Discectomy; Pedicle; Radiculopathy; Myelopathy1998
236 Couldwell, William T.Communication between malignant glioma cells and vascular endothelial cells through gap junctionsObject. Extensive invasion and angiogenesis are hallmark features of malignant gliomas. Communication between malignant glioma cells and surrounding astrocytes occurs, resulting in transformation of the astrocytic phenotype. In the present study, the authors examined whether malignant glioma cells a...2003-01-01
237 Couldwell, William T.; MacDonald, Joel D.Surgical strategies for recurrent craniofacial meningiomasRecurrent cranial base meningiomas are among the most difficult tumors to treat surgically. Although they are histologically benign, these tumors often invade through the cranial base into the infratemporal and pterygopalatine fossae. We reviewed our experience with these tumors to describe the nat...Craniofacial meningiomas; Recurrence; Cranial base tumor; Neoplasm2006
238 Couldwell, William T.Development of neurosurgery in Southern California and the Los Angeles County/University of Southern California Medical CenterThe Los Angeles County General Hospital has played an integral role in the development of medicine and neurosurgery in Southern California. From its fledgling beginnings, the University of Southern California School of Medicine has been closely affiliated with the hospital, providing the predomina...Historical vignette; Los Angeles County General Hospital; University of Southern California School of Medicine; Neurosurgical history1993
239 Kestle, John R. W.It's randomized and double blinded... what more do we want?This issue of Journal of Neurosurgery: Pediatrics presents a randomized trial in which investigators have evaluated antimicrobial suture (AMS) in the prevention of shunt infection. The authors randomized 84 shunt procedures in 61 patients over 21 months. The surgeons and patients were blinded to...2008
240 Couldwell, William T.Use of cylindrical titanium mesh and locking plates in anterior cervical fusionAfter performing anterior cervical corpectomy or discectomy for cervical spondolytic myelopathy or radiculopathy, iliac crest bone graft and fibular auto- or allograft is often used to achieve arthrodesis in the cervical spine. The purpose of this study was to evaluate the use of a cylindrical titan...Anterior cervical fusion; Arthrodesis; Cylindrical titanium mesh; Lordosis; Kyphosis2001
241 Couldwell, William T.Increasing exposure of the petrous internal carotid artery for revascularization using the transzygomatic extended middle fossa approach: a cadaveric morphometric studyWhen internal carotid artery (ICA) sacrifice is planned in the management of difficult tumors or aneurysms at the cranial base, the petrous ICA may be a useful site for anastomosis for interpositional vascular bypass. However, exposure of the artery and performing an anastomosis in this region may...Revascularization; Internal carotid artery; Cranial base tumors; Giant aneurysms; Interpositional bypass; Surgical approach; Middle fossa2006
242 Digre, Kathleen B.; Blumenthal, Deborah T.; Salzman, Karen L.; Jensen, Randy L.; Dunson, William A.Early pathologic findings and long-term improvement in anti-Ma2-associated encephalitis.A 67-year-old man sequentially developed anti-Ma2-associated paraneoplastic encephalitis (PNE) and contralateral herpes simplex encephalitis (HSE). Brain biopsy 1 month before HSE revealed extensive infiltrates of T cells, B cells, and plasma cells. Most T cells expressed the cytotoxic granule-assoc...Paraneoplastic neurologic disorders; Encephalitis; Neoplasm;Herpes Simplex2006-07-11
243 Couldwell, William T.Fenestration of the oculomotor nerve by a duplicated posterior cerebral artery and aneurysmThe authors report a case of a posterior cerebral artery aneurysm arising from an aberrant arterial branch that was found to be splitting the oculomotor nerve. This 63-year-old man presented with headaches, and CT imaging revealed subarachnoid hemorrhage primarily within the basilar cisterns. Formal...2009-01-01
244 Kestle, John R. W.; Simon, Tamara DanielleInfection rates following initial cerebrospinal fluid shunt placement across pediatric hospitals in the United StatesObject. Reported rates of CSF shunt infection vary widely across studies. The study objective was to determine the CSF shunt infection rates after initial shunt placement at multiple US pediatric hospitals. The authors hypothesized that infection rates between hospitals would vary widely even after ...Shunt placement; Pediatric neurosurgery2009
245 Garber, SarahSpinal arteriovenous fistulas in children with hereditary hemorrhagic telangiectasia: report of 2 casesHereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant angiodysplasia with high penetrance and variable expression. The manifestations of HHT are often age related, and spinal arteriovenous fistula (AVF) may be the initial presentation of HHT in young children. Because spinal AVFs are...2012-01-01
246 Couldwell, William T.Submandibular high-flow bypass in the treatment of skull base lesions: an analysis of long-term outcomeBackground: Cerebral bypass surgery remains an integral part of the treatment of complex skull base tumors and unclippable aneurysms. Objective: The authors retrospectively analyzed a single-surgeon experience using a high-flow submandibular-infratemporal saphenous vein graft bypass technique after ...2012-01-01
247 Couldwell, William T.Surgical treatment of craniofacial fibrous dysplasia in adultsCraniofacial fibrous dysplasia is a rare disorder that may require neurosurgical expertise for definitive management; however, surgical management of FD in adult patients is uncommon. Although other therapies have been shown to slow progression, the only definitive cure for adult craniofacial FD is ...2014-01-01
248 Couldwell, William T.Surgical fidelity: comparing the microscope and the endoscopeBackground: Both the microscope and the endoscope are widely used as visualization tools in neurosurgery; however, surgical dexterity when operating with endoscopic visual control may differ. The aim of this study was to compare the surgical fidelity when using each of these visualization tools. Met...2013-01-01
249 Couldwell, William T.Surgical approaches for resection of vestibular schwannomas: Translabyrinthine, retrosigmoid, and middle fossa approachesSurgical removal remains one of the key treatment modalities for vestibular schwannomas. A team approach between a neurotologist and a neurosurgeon offers the patient the expertise of both specialties and maximizes the chances for an optimal outcome. Vestibular schwannomas can typically be resected ...2012-01-01
250 Couldwell, William T.Normal dimensions of the posterior pituitary bright spot on magnetic resonance imaging: Clinical articleObject. The normal pituitary bright spot seen on unenhanced T1-weighted MRI is thought to result from the T1-shortening effect of the vasopressin stored in the posterior pituitary. Individual variations in its size may be difficult to differentiate from pathological conditions resulting in either ab...2014-01-01
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