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1 Digre, Kathleen B.Significance of CT and MR findings in sphenoid sinus disease.Disorders of the paranasal sinuses, particularly the sphenoid sinus, can be associated with significant disorders of the optic and other cranial nerves. We examined 100 consecutive routine CT scans, 100 posterior fossa CT scans, and 100 MR scans to look for evidence of sinus disease, especially of t...Sphenoid Sinus; Vision Disorders; Paranasal Sinus Diseases; Magnetic Resonance Imaging1989-05
2 Varner, Michael W.Endotoxin enhancement as a possible etiology of early-onset group B beta-hemolytic streptococcal sepsis in the newborn.Group B streptococcal cells, either viable or heat-killed, contain a substance that induced fever in rabbits with maximal responses occurring four hours after intravenous injection. In contrast, supernatant fluids failed to induce significant fever. Group B streptococcal cells also enhanced host sus...Newborns; Endotoxins; Group B Beta-Hemolytic Streptococcal Sepsis1983-05
3 Varner, Michael W.Reduction in amniocentesis risks using a real-time needle guide procedure.Rates of complications associated with a second trimester genetic amniocentesis were studied in 918 patients, and complete infant follow-up was obtained. In 903 singleton pregnancies and 15 twin gestations, the procedure was performed under continuous sector scanning guidance through an attached nee...Amniocentesis; Ultrasonography; Pregnancy2007-01-25
4 Varner, Michael W.Human placental lactogen: a predictor of perinatal outcome?Serial human placental lactogen (hPL) determinations were performed on 806 women with normal and abnormal pregnancies late in the pregnancy. These results were not reported to the clinicians involved. For the study population as a whole, low hPL levels did not effectively predict those adverse perin...Infant, Newborn; Placental Lactogen; Pregnancy; Prenatal Diagnosis1979-08
5 Varner, Michael W.Blood transfusion and cesarean delivery.OBJECTIVE: To evaluate risks for intraoperative or postoperative packed red blood cell transfusion in women who underwent cesarean delivery. METHODS: This was a 19-university prospective observational study. All primary cesarean deliveries from January 1, 1999, to December 31, 2000, and all repeat c...Blood Transfusion; Postpartum Hemorrhage; Pregnancy Complications; Anemia2006-10
6 Gouw, Launce G.; McKenna, Catherine K.; Digre, Kathleen B.; Placek, Louis J.Analysis of the dynamic mutation in the SCA7 gene shows marked parental effects on CAG repeat transmission.The gene for spinocerebellar ataxia 7 (SCA7) includes a transcribed, translated CAG tract that is expanded in SCA7 patients. We have determined expansions in 73 individuals from 17 SCA7 kindreds and compared them with repeat lengths of 180 unaffected individuals. Subjects with abnormal expansions co...Genetics; Biosynthesis; SCA7 Gene1998-03-07
7 Frederick, Jeanne M.; Thulin, Craig; Bernstein, Paul S.Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eyeUptake, metabolism, and stabilization of xanthophyll carotenoids in the retina are thought to be mediated by specific xanthophyll-binding proteins (XBPs). A membrane-associated XBP was purified from human macula using ion-exchange chromatography followed by gel-exclusion chromatography. Two-dimensio...Circular Dichroism; Isoelectric Focusing; Macula Lutea; Xanthophylls2004
8 Digre, Kathleen B.; Kleinschmidt, Julia J.; Hanover, RitaIdiopathic intracranial hypertension. Relationship to depression, anxiety, and quality of lifeOBJECTIVE: To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not d...Intracranial Hypertension; Depression; Anxiety; Quality of Life2000-01-25
9 Varner, Michael W.; Digre, Kathleen B.Pseudotumor cerebri and pregnancy.Pseudotumor cerebri (PTC) is most commonly seen in obese women of reproductive age. We studied 109 women with PTC between ages 16 and 44 years. In 11, PTC started during pregnancy. Thirteen women with previous diagnosis of PTC, including two of the aforementioned 11, had an additional 17 documented ...Pregnancy Complications; Pseudotumor Cerebri; Vision disorders; Headache; Intracranial Pressure1984-06
10 Varner, Michael W.; Clark, Edward B.; Fernando, Kumari L.; Mathews, V. JohnRobust estimation of fetal heart rate variability using Doppler ultrasound.This paper presents a new measure of heart rate variability (HRV) that can be estimated using Doppler ultrasound techniques and is robust to variations in the angle of incidence of the ultrasound beam and the measurement noise. This measure employs the multiple signal characterization (MUSIC) algori...Prenatal Ultrasonography; Fetal Heart Rate; Blood Flow Velocity; Algorithms2003-08
11 Varner, Michael W.; Digre, Kathleen B.Cranial magnetic resonance imaging in eclampsia.Although the precise neuropathologic basis for eclamptic convulsions remains unclear, intracranial hemorrhage is frequently associated with fatal cases. Magnetic resonance imaging (MRI) is a recently developed neuroimaging technique that appears superior to other processes for defining intracranial ...Eclampsia; Brain Edema; Cranial Magnetic Resonance Imaging1987-09
12 Varner, Michael W.Spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy.OBJECTIVE: We sought to estimate the rate of spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy and to evaluate factors associated with its resolution. METHODS: A cohort of women enrolled in a large multicenter randomized bacterial vaginosis antibiotic trial (metronidazole ver...Pregnancy; Chlamydia Trachomatis; Sexually Transmitted Diseases2005-03
13 Varner, Michael W.Physiologic changes in pregnancy: surgical implications.Pregnancy has measurable effects on essentially every organ system in a woman's body. An understanding of these changes is vital for determining what is normal or abnormal in a pregnant woman. These changes frequently alter symptoms and signs of surgical diseases during pregnancy. In addition, ma...Pregnancy; Physiologic Changes; Surgical Implications1994-06
14 Varner, Michael W.Serial salivary estriol to detect an increased risk of preterm birth.OBJECTIVE: To evaluate serial measurements of salivary estriol (E3) to detect increased risk of spontaneous preterm labor and preterm birth. METHODS: A masked, prospective, multicenter trial of 956 women with singleton pregnancies was completed at eight United States medical centers. Saliva was coll...Estriol; Preterm Birth; Spontaneous Preterm Labor2000-10
15 Digre, Kathleen B.Not so benign intracranial hypertension.Despite many controversies, intracranial hypertension due to use of doxycycline does occur. Practitioners prescribing the tetracyclic antibiotics should be aware of the syndrome of increased intracranial pressure, and pay particular attention to the ocular fundus for papilloedema. Appropriate referr...Venous Occusion; Venous Hypertension; Tetracycline, Doxycycline; Minocycline2003-03-22
16 Varner, Michael W.Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor.OBJECTIVE: To determine whether elevated concentrations of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in amniotic fluid (AF) are related to term and preterm labor. METHODS: Amniotic fluid was obtained from women from five different clinical situations: 1) term cesarean delivery, no labor ...Amniotic Fluid; Macrophage Inflammatory Protein-1; Obstetric Labor, Premature1996-01
17 Varner, Michael W.Asthma during pregnancyOBJECTIVE: To determine neonatal and maternal outcomes stratified by asthma severity during pregnancy by using the 1993 National Asthma Education Program Working Group on Asthma and Pregnancy definitions of asthma severity. The primary hypothesis was that moderate or severe asthmatics would have an ...Asthma; Infant, Newborn; Pregnancy Outcomes2004-01
18 Buchi, Karen F.; Varner, Michael W.Changing prevalence of prenatal substance abuse in Utah.OBJECTIVE: To estimate the current prevalence of prenatal exposure to methamphetamines and other drugs of abuse among infants born in Utah and compare the results with those of a maternal substance abuse prevalence study performed in 1991 in the same geographic area. METHODS: Thirteen well baby nurs...Street Drugs; Prenatal Care; Maternal Exposure; Infant, Newborn2003-06-12
19 Varner, Michael W.Decidual, amniotic fluid, maternal and fetal prolactin in normal and abnormal pregnancies.In the present studies, the content and the in vitro production of prolactin by decidua as well as the concentrations of prolactin in amniotic fluid, maternal and fetal serum in normal term pregnancies, induced abortions at various gestational ages, and in pregnancies complicated by diabetes mellitu...Decidual; Amniotic Fluid; Prolactin; Pregnancy Complications1984-03
20 Varner, Michael W.Diagnosis of maternal cystic fibrosis during pregnancy.The third and fourth cases of maternal cystic fibrosis diagnosed during pregnancy are presented. Quantitative pilocarpine iontophoresis (sweat chlorides) must be performed to establish the diagnosis. Other important findings include recurrent or persistent respiratory symptoms, chest x-ray abnormali...Pregnancy; Cystic Fibrosis; Chlorides; Respiratory Insufficiency1983-03
21 Varner, Michael W.Does progesterone treatment influence risk factors for recurrent preterm delivery?OBJECTIVE: To examine how demographic and pregnancy characteristics can affect the risk of recurrent preterm delivery and the how the effectiveness of progesterone treatment for prevention alters these relationships. METHODS: This was a secondary analysis of a randomized trial of 17alpha-hydroxyprog...Preterm Delivery; Progesterone Treatment; Pregnancy; Risk Factors2005-09
22 Varner, Michael W.Episiotomy: techniques and indications.In current obstetric practice episiotomy is generally taken to refer to an incision of the perineum and vagina to facilitate vaginal delivery. While the most precise definition of this incision is perineotomy, episiotomy is the generally employed terminology and thus is used in this article. The e...Episiotomy; Adverse Effects; Perineotomy1986-06
23 Varner, Michael W.Fetal injury associated with cesarean delivery.OBJECTIVE: To describe the incidence and type of fetal injury identified in women undergoing cesarean delivery. METHODS: Between January 1, 1999, and December 31, 2000, a prospective cohort study of all cesarean deliveries was conducted at 13 university centers. Information regarding maternal and in...Birth Injuries; Cesarean Section; Adverse Effects2006-10
24 Varner, Michael W.Intergenerational predisposition to operative delivery.OBJECTIVE: To determine the risk of cesarean delivery for women who themselves were born via operative delivery. METHODS: A linked data base was constructed between the birth certificates of individuals born in Utah during 1947-1957 (parental cohort) and who subsequently became a parent of offspring...Cesarean Section; Cohort Studies; Delivery, Obstetric; Obstetric Labor Complications1996-06
25 Varner, Michael W.Maternal mortality in Utah.OBJECTIVE: To determine trends in maternal deaths in Utah, identify opportunities for preventive intervention, and analyze the mechanism of reporting maternal deaths. METHODS: A retrospective review was performed of maternal death certificates and medical records in Utah from January 1, 1982, throug...Maternal Death; Utah; Pregnancy; Trauma; Pulmonary Emboliam; Maternal Cardiac Disease1998-02
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