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Clonally-Expanded Plasma Cells in Neuromyelitis Optica Cerebrospinal Fluid Produce IgG Against Aquaporin-4 | Bennett, Jeffrey; Lam, Chiwah; Bautista, Katherine; DuPree, Cecily; Glogowska, Magdalena; Case, David; Saikali, Philippe; Antel, Jack; Reddy, Sudhakar; Hemmer, Bernhard; Owens, Gregory; Gilden, Donald | Neuromyelitis optica immunoglobulin G (NMO-IgG) binds the aquaporin-4 (AQP-4) water channel of astrocytes that are abundant in the perivessel and subpial areas of the brain. NMO-IgG appears specific for NMO and is now included as a diagnostic criterion for disease. | 20090224_nanos_sciplatform_08.pdf |