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Low-Contrast Letter Acuity Loss Over Time in Multiple Sclerosis Correlates with Reductions in Retinal Nerve Fiber Layer Thickness and Macular Volume by OCT | Burkholder, Bryn; Winslow, Heather; Nano-Schiavi, M. L.; Pulicken, Mathew; Calabresi, Peter; Galetta, Steven L; Frohman, Elliot; Balcer, Laura J | Low-contrast letter acuity testing is being used with increasing frequency as an MS trial outcome. This measure demonstrated treatment effects in recent phase 3 trials of natalizumab, capturing sustained, clinically-significant visual loss. Optical coherence tomography (OCT) parameters of retinal ne... | 20070213_nanos_sciplatform_01.pdf |