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The Genetic Testing Paradigm for Leber's Hereditary Optic Neuropathy: Discovery of a New Candidate LHON Mitochondrial DNA Mutation | Brown, Michael D; Biousse, Valerie; Hosseini, Seyed H; Wallace, Douglas C; Newman, Nancy J | Leber's Hereditary Optic Neuropathy (LHON) is a maternally inherited disorder caused by mitochondrial DNA(mtDNA) mutations. Roughly 30 different mtDNA mutations have been associated with LHON, with variants at nucleotide positions (np) 3460, 11778, and 14484 ("primary" mutations) comprising about 80... | 20040331_nanos_posters_060 |