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| Title | Author | Subject | Description | Date | ||
|---|---|---|---|---|---|---|
| 1 |  | In vitro activation of procarbazine to sytotoxic species | Swaffar, Diane Shomin | Metabolites; Metabolism | Procarbazine is a 1,2-disubstituted hydrazine derivative that acts as a methylating agent in the treatment of Hodgkin's disease, leukemias, lymphomas, and brain tumors. The anticancer activity of this agent results from oxidation to azoprocarbazine and additional N-oxidation to a mixture of azoxy is... | 1991-08 |
| 2 |  | Function and regulation of pulmonary expressed cytochrome P450 enzymes | Carr, Brian Allen | Xenobiotic; Metabolism; Polymorphisms | Humans are exposed to a variety of inhaled and systemic xenobiotic compounds that cause respiratory toxicity. Cytochrome P450 enzymes, expressed specifically in lung tissues, are known to bioactivate these xenobiotics to reactive pneumotoxic and carcinogenic intermediates. Thus, differential, tissue... | 2003-08 |
| 3 |  | Organ and enzyme selectivity and toxicological significance of cytochrome P450 induction and inhibition elicited by nitrogen heterocycles | Harmsworth, Wendy Lynn | Kidney; Liver; Metabolism; Xenobiotics; Pharmacokinetics; Pharmacology; Polycyclic Hydrocarbons; Toxicology | The metabolism of xenobiotics by extrahepatic cytochrome P450 (P450) may be integral in the development of organ-selective toxicities. Some xenobiotics also induce extrahepatic P450, and the polycyclic aromatic hydrocarbon (PAH)-type agents are generally considered the most effective inducers in the... | 1991-03 |
| 4 |  | Investigation of the primary stimulus and mechanism of the ammonium chloride-induced increase in the content of potassium in choroid plexus epithelial cells | Harbut, Ronald Eugene Daniel | Metabolism; Potassium | After young adult male rate were injected intraperitoneally with NH4C1, the content of K (hereafter, CP [K]) within the epithelial cells of the choroid plexus increased greatly while that of Na (CP [K]) decreased. This dissertation has focused on elucidating the primary stimulus and mechanism of t... | 1983-06 |
| 5 |  | In vivo 4-hydroxylation of amphetamine in the rat | Law, Michael Yiu Lun. | Metabolism; Hydrosylation | The predominant pathway for amphetamine metabolism in the rat is 4-hydroxylation. Limited in vitro data on the inhibition of debrisoquine hydroxylation by amphetamine suggest cytochrome P-450 (P450) 2D1 has a role in this reaction. In a preliminary experiment in which Lewis rats were pretreated with... | 1994-08 |
| 6 |  | Effect of cycloheximide treatment on the mixed-function oxidase system of rat liver | Williams, Joseph Francis | Metabolism; Drugs; Cycloheximide; Rats | The effect of cycloheximide treatment on the mixed-function oxidase system of rat liver was studied at 12 and 24 hours after administration of the antibiotic. Protein synthesis was inhibited in the animals for the 24-hour experimental period with the maximal tolerable dose, 2 mg/kg. Cycloheximide... | 1971-06 |
| 7 |  | Effects of stimulation on intracellular calcium in frog sartorius muscle | Webb, Jerry Glen | Metabolism; Pharmacokinetics | The cellular state and distribution of calcium were investigated in frog sartorius muscle at rest and following periods of stimulation. The purpose of the experiments was to define the relative importance of the various cell organelles in the regulation of intracellular calcium. Stimulation increa... | 1972-06 |
| 8 |  | Metabolism and mechanism of toxicity of 3-methylindole in human and goat tissues | Ruangyuttikarn, Werawan | Metabolism; Protiens | 3-Methylindole (3MI), a highly selective pneumotoxin in ruminants, horses, sheep and rodents, is an anaerobic bacterial fermentation product of tryptophan formed in the rumen of ruminants and in the large intestine of man. Toxicity in humans is not known, despite significant human exposures to 3MI f... | 1991-12 |
| 9 |  | Study of the relationship between sodium ion and hydrogen ion regulation in rat skeletal muscle | Elsmore, Trudy Ann | Metabolism; Physiology; Hydrogen Ions | The purpose of this study was to elucidate the relationship between the active transport of sodium and the regulation of intracellular pH in rat skeletal muscle. Experiments were conducted both in vivo and in vitro in which Na transport and tissue acid-base balance changed independently and concurr... | 1968-06 |
| 10 |  | Species and strain differences in xenobiotic-mediated induction of hepatic drug metabolizing enzymes | Manning, Bradford W. | Therapeutic Use; Metabolism; Analogs and derivatives | The nature of extent of drug metabolizing enzyme induction by exogenous compounds is often dependent on the animal being investigated, the chemical nature of the xenobiotic and the specific dosing protocol. Herein, the effects of both traditional and nontraditional inducing agents on the biotransfor... | 1991-03 |
| 11 |  | Induction and inhibition of rat hepatic drug metabolism by imidazoles. | Ritter, Joseph Kraft. | Pharmacokinetics; Metabolism; Drug Effects | The characteristics of inhibition and induction by imidazoles, and their possible relationship, were investigated. The N-substituted imidazole clotrimazole (CloTZ) was a strong inhibitor of in vitro cytochrome P-450 associated monooxygenase activity. So potent was its inhibition of monooxygenase act... | 1987-03 |
| 12 |  | The direct effects of desoxycorticosterone on skeletal muscle electrolyte metabolism. | Withrow, Clarence Dean | Tissue; Metabolism; Drugs; Pharmacology | It has been found that the primary effects of DCA upon skeletal muscle, particularly the effect upon sodium movements, are masked by electrolyte shifts that are secondary to muscle potassium depletion. The muscle potassium depletion is caused by an action of DCA to promote potassium excretion via t... | 1959-08 |
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