UScholar Works
 
Filters: Collection: "ir_uspace"
1 - 25 of 75
Number of results to display per page
CreatorTitleDescriptionSubjectDate
1 Jayamohan, HarikrishnanAdvances in microfluidics and lab on a chip technologiesAdvances in molecular biology are enabling rapid and efficient analyses for effective intervention in domains like biology research, infectious disease management, food safety and bio-defense. The emergence of microfluidics and nanotechnologies has enabled both new capabilities and instrument sizes ...Microfluidics; Lab on a chip; Point of care; PCR; Isothermal amplification; High resolution melting analysis; Cytogenetics; Protein detection; Next generation sequencing; Sample preparation; Library preparation; Cell sorting2017
2 Mansour, Suzanne L.Fgf10 is required for specification of non-sensory regions of the cochlear epitheliumThe vertebrate inner ear is a morphologically complex sensory organ comprised of two compartments, the dorsal vestibular apparatus and the ventral cochlear duct, required for motion and sound detection, respectively. Fgf10, in addition to Fgf3, is necessary for the earliest stage of otic placode ind...2014-01-01
3 Berzins, MartinParallel breadth first search on GPU clustersFast, scalable, low-cost, and low-power execution of parallel graph algorithms is important for a wide variety of commercial and public sector applications. Breadth First Search (BFS) imposes an extreme burden on memory bandwidth and network communications and has been proposed as a benchmark that m...2014-01-01
4 Dwight, Zachary LawrenceHeterozygote PCR product melting curve predictionMelting curve prediction of PCR products is limited to perfectly complementary strands. Multiple domains are calculated by recursive nearest-neighbor thermodynamics. However, the melting curve of an amplicon containing a heterozygous single nucleotide variant (SNV) after PCR is the composite of four...2014-01-01
5 Planelles, VicenteKinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivationDespite the clinical relevance of latent HIV-1 infection as a block to HIV-1 eradication, the molecular biology of HIV-1 latency remains incompletely understood. We recently demonstrated the presence of a gatekeeper kinase function that controls latent HIV-1 infection. Using kinase array analysis w...2014-01-01
6 Jorde, Lynn B.Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: A report from the Childrens Oncology GroupBackground: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and prelimina...2014-01-01
7 Nebeker, Jonathan R.pSCANNER: Patient-centered scalable national network for effectiveness researchThis article describes the patient-centered Scalable National Network for Effectiveness Research (pSCANNER), which is part of the recently formed PCORnet, a national network composed of learning healthcare systems and patient-powered research networks funded by the Patient Centered Outcomes Research...2014-01-01
8 Leslie Podlog

Podlog, L., Kleinert, J., Dimmock, J., Miller, J. & Shipherd, A. (2012). A parental perspective on adolescent injury recovery and return to sport experiences. Journal of Applied Sport Psychology, 24, <.<

2012-03-01
9 Mitchell, Joyce A.Nanoinformatics: a new area of research in nanomedicineAbstract: Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, wit...2012-01-01
10 Stoddart, JoanRethinking information delivery: using a natural language processing application for point-of-care data discoveryObjective: This paper examines the use of Semantic MEDLINE, a natural language processing application enhanced with a statistical algorithm known as Combo, as a potential decision support tool for clinicians. Semantic MEDLINE summarizes text in PubMed citations, transforming it into compact declarat...2012-01-01
11 Ostafin, AgnesNanomedicine making headway across the blood brain barrierNanotechnological advances implemented by nanomedicine have allowed significant development of imaging strategies, therapeutics and theranostics for many severe and life threatening diseases such as brain tumors, Alzheimer's disease, Parkinson's disease and other neurological disorders. The Blood-Br...2012-01-01
12 Tvrdik, PetrGene targeting in the mouse nervous systemOur understanding of the development, connectivity and function of the nervous system has been facilitated by gene targeting technology. Here we summarize the historic background and the current state of this experimental approach with specific regard to neuroscience research. I. The Pioneering Expe...2012-01-01
13 Mower, AllysonExploring publishing patterns at a large research university: Implications for library practiceObjective - The research project sought to explore the value of data on publication patterns for decision-making regarding scholarly communications and collection development programs at a research-intensive post-secondary institution, the University of Utah in the United States. Methods - Publicati...2012-01-01
14 Light, Alan R.ASICs do not play a role in maintaining hyperalgesia induced by repeated intramuscular acid injectionsRepeated intramuscular acid injections produce long-lasting mechanical hyperalgesia that depends on activation of ASICs. The present study investigated if pH-activated currents in sensory neurons innervating muscle were altered in response to repeated acid injections, and if blockade of ASICs revers...2012-01-01
15 Slev, Patricia R.Review: Host genomics and HCV personalized medicineIt is estimated that there are 4.0 million individuals chronically infected with Hepatitis C virus (HCV) in the US. Due to the slow progression of disease, the incidence of HCV has declined in the last two decades. However, it is anticipated that the number of individuals requiring treatment for liv...2012-01-01
16 Suchy, YanaAberrant functional connectivity of cortico-basal ganglia circuits in major depressionThere is considerable evidence of functional abnormalities of the cortico-basal ganglia circuitry in affective disorders. However, it has been unknown whether this represented primary pathology within these circuits or altered activation as a result of aberrant input from other brain regions. The ai...2012-01-01
17 Olivera, Baldomero M.Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptomeThe venom peptides (i.e., conotoxins or conopeptides) that species in the genus Conus collectively produce are remarkably diverse, estimated to be around 50,000 to 140,000, but the pace of discovery and characterization of these peptides have been rather slow. To date, only a minor fraction have be...2012
18 Mitchell, Joyce A.International efforts in nanoinformatics research applied to nanomedicineBackground: Nanomedicine and nanoinformatics are novel disciplines facing substantial challenges. Since nanomedicine involves complex and massive data analysis and management, a new discipline named nanoinformatics is now emerging to provide the vision and the informatics methods and tools needed fo...2011-01-01
19 Mitchell, Joyce A.50 Years of informatics research on decision support: what's nextObjectives: To reflect on the history, status, and future trends of decision support in health and biomedical informatics. To highlight the new challenges posed by the complexity and diversity of genomic and clinical domains. To examine the emerging paradigms for sup - porting cost-effective, person...2011-01-01
20 Voth, Gregory Alan; Ayton, Gary S.Role of protein interactions in defining HIV-1 viral capsid shape and stability: a coarse-grained analysisCoarse-grained models of the HIV-1 CA dimer are constructed based on all-atom molecular dynamics simulations. Coarse-grained representations of the capsid shell, which is composed of approximately 1,500 copies of CA proteins, are constructed and their stability is examined. A key interaction between...Virus capsid; HIV-1; Viral capsid shape; Coarse-graining; CA dimer2010-01
21 Mastrangelo, Carlos H.Detection of biomolecular binding by fourier-transform SPRSurface plasmon resonance (SPR) is a widely used label-free detection technique that has many applications in drug discovery, pharmacokinetics, systems biology and food science. The SPR technique measures the dynamics of a biomolecular interaction at a surface, yielding kinetic association and diss...2010
22 Olivera, Baldomero M.Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxinsPeptidylprolyl cis-trans isomerases (PPIases) are ubiquitous proteins that catalyze the cis-trans isomerization of prolines. A number of proteins, such as Drosophila rhodopsin and the human immunodeficiency viral protein HIV-1 Gag, have been identified as endogenous substrates for PPIases. However, ...2010
23 Planelles, VicenteMethod for obtaining an enriched population of sirna-expressing cellsProblems with transience of siRNA-mediated knock-down and transfection efficiency have limited the scope of RNAi-based experiments. The invention provides a tool for employing RNAi more efficiently and effectively by integrating RNAi expression with methods of cell enrichment.2010
24 Olivera, Baldomero M.Biochemical characterization of ?M-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of ?M-conotoxinsConus snail (Conus) venoms are a valuable source of pharmacologically active compounds; some of the peptide toxin families from the snail venoms are known to interact with potassium channels. We report the purification, synthesis, and characterization of ?M-conotoxin RIIIJ from the venom of a fish-...2010
25 Mastrangelo, Carlos H.Probing protein binding spectra with fourier microfluidicsNew developments in microfluidic chip technology enable the construction of chemical spectrum analyzers that can probe the binding interactions between chemical entities. In this paper we report the implementation of a microfluidic chip suitable for Fourier transform measurements of biochemical int...2010
1 - 25 of 75