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1 Enhancement of Vascular Stability Through ARF6 Deactivation Reduces Inflammatory PathologiesThe vasculature infuses nearly every tissue with oxygen and nutrients. It facilitates the transport of cells and chemical messages throughout the body and maintains proper fluid balance in the individual tissues. During angiogenesis and inflammation, vessels that compose the vasculature display enha...2014-08
2 COMP-1 Regulates Male and Hermaphrodite Bias of Sperm Selection in Caenorhabditis ElegansSperm competition is a pervasive mode of sexual selection across the phyla that have crucial implications in microevolutionary and macroevolutionary processes. Furthermore, females can bias the selection of sperm from one male over another in a process known as cryptic female choice. While sperm com...2015-05
3 Regulation of development and metabolic homeostasis by hepatocyte nuclear factor 4The maintenance of metabolic homeostasis presents a major challenge to animal biology. Dysregulation of this process is central to the etiology of diabetes and obesity, which have placed an ever-increasing burden on global human health. Nuclear receptors are a family of ligand-regulated transcriptio...Molecular biology; Genetics; Developmental biology2016
4 Functional Analysis of the Mitochondrial Proteome in DrosophilaMitochondria are complex organelles that have important roles in energy production, intermediary metabolism, signal transduction, and apoptosis. Given these critical cellular functions, major efforts have been made to determine the identity of the mitochondrial proteome. Remarkably, about one fifth ...2014-05
5 Improved Methods for Next Generation Sequencing-Based Conotoxin DiscoveryCone snails (genus Conus) have attracted scientific interest for the great neuropharmacological potential of their venoms to treat chronic pain, which consist of a complex mixture of peptides known as conotoxins. For discovery purposes, we have carried out a survey of the venom-ducts of 22 Conus spe...Bioinformatics2017
6 Attenuation of Decapentaplegic Signaling Via a Localized Chondroitin-Sulfated Signaling SinkGlycosaminoglycans (GAGs) are long linear polysaccharides made of disaccharide repeats. The GAGs heparan and chondroitin are found ubiquitously on cell surfaces in many organisms and are involved in regulating developmental signaling, immunity, and mediating many cell-cell interactions. In Drosophil...2014-12
7 Developing Computational Methods for Studying nonmodel Organism Genetics and Human Disease with Next-Generation Sequencing DataThe rapidly decreasing of costs of sequencing is revolutionizing genetics. Two applications of next-generation sequencing data are of particular importance in this regard. First, high-throughput sequencing now offers a fast and inexpensive means to investigate the genomes and genetics of nonmodel or...2012-12
8 Discovery and Analysis of Components of Nonsense Mediated Decay in DrosophilaNonsense mediated decay (NMD) is a cellular surveillance mechanism originally identified for its role in targeting mRNAs containing nonsense codons for rapid degradation. Nonsense codons, or premature termination codons (PTCs), are a common result of genomic mutation, alternative splicing, and progr...Genetics2013-05
9 A Seminal Fluid Serine Protease, TRY-5, Signals Caenorhabditis Elegans Sperm ActivationDuring mating males transfer not only sperm, but also protein and other substances in their seminal fluid. The functions of some seminal fluid components have been identified and these include aiding in sperm motility and protecting sperm from the harsh environment of the female reproductive tract. ...2012-08
10 Metabolic Regulation at the Intersection of Genes and EnvironmentThe incidence of complex metabolic disease has risen to an alarming level in the last several decades. This elevated frequency has been accompanied by increased social and financial costs, with nearly $250 billion spent each year on diabetes alone. Despite this growing health crisis, only a small pe...2016-08
11 Endogenous retrovirus evolution in mammalian genomesEndogenous retroviruses (ERVs), derived from exogenous retroviruses (XRVs), comprise about 5 to 10 % of most mammalian genomes. We can study retroviral infection which originated millions years ago and understand long term evolution of infectious viruses by working on ERVs. At the same time, it has ...Genetics; Evolution and Development; Virology2017
12 Posttranscriptional Gene Regulation by the DMD 3'UTRDuch enne muscular dystrophy (DMD) and the milder Becker muscular dystrophy (BMD) are both caused by mutations in the DMD gene, which encodes the protein dystrophin. Its regulation is of therapeutic interest as even small changes in expression of functional dystrophin can significantly im pac...2014-08
13 The Roles of The Laminin Extracellular Matrix and Migratory Neural Crest Cells During Optic Cup MorphogenesisThe development of an organ involves establishment of its shape, which is often critical for proper function. Perhaps the most striking case where organ shape dictates function is in the vertebrate eye, where vision depends on many tissues taking on the correct shape, and becoming correctly oriented...Developmental biology; Cellular biology2018
14 Whole or Hole? Development of the Diaphragm and Congenital Diaphragmatic HerniasThe mammalian diaphragm is the most critical skeletal muscle and defects in the development of the diaphragm give rise to congenital diaphragmatic hernias (CDH), which are common and frequently lethal birth defects. The diaphragm has been proposed to develop from multiple embryonic sources, but how ...2014-08
15 Platelets, Cytokines, and Proangiogenic Factors in the Maintenance of Vessel IntegrityAlmost all vascular diseases are linked to an inflammatory milieu that produces a toxic brew of angiogenic and inflammatory cytokines, which distort tissue architecture and function. These cytokines are produced by a cohort of cells, including endothelial cells, which line blood vessels, and immune ...2015-08
16 Genotype-Phenotype Association Using High Throughput Sequencing DataGenotype Phenotype Association (GPA) is a means to identify candidate genes and genetic variants that may contribute to phenotypic variation. Technological advances in DNA sequencing continue to improve the efficiency and accuracy of GPA. Currently, High Throughput Sequencing (HTS) is the preferred ...2015-08
17 Combining Phenotype and Genotype for Discovery and Diagnosis of Genetic DiseaseSuccessful molecular diagnosis using an exome sequence hinges on accurate association of damaging variants to the patient's phenotype. Unfortunately, many clinical scenarios (e.g., single affected or small nuclear families) have little power to confidently identify damaging alleles using sequence da...2015-08
18 Analysis of the Physiological Roles of the Nonsense Mediated mRNA Decay Pathway in Drosophila MelanogasterThe nonsense mediated mRNA decay (NMD) pathway is a conserved posttranscriptional mRNA decay pathway that functions to destabilize a variety of naturally occurring target mRNAs. The NMD pathway functions in all eukaryotes and regulates a significant portion of the transcriptome. It is thought that t...2014-08
19 Jun Signaling During Drosophila DevelopmentJun N-terminal kinase (JNK) signaling is a key modulator of development and disease in all multicellular organisms. One process in which the consequences of both gain and loss of JNK signaling can be monitored is embryonic dorsal closure (DC) in the fruit fly, Drosophila melanogaster. DC occurs midw...2016-05
20 Genetic Basis of Distal ArthrogryposesEvery year millions of children are born with a birth defect. Birth defects, which can be described as abnormalities of structure or function that is present from birth, are the leading cause of infant death in developed countries and a significant cause of morbidity and economic burden in low- or m...2006-12
21 Modeling Clear Cell SarcomagenesisClear cell sarcoma (CCS) is a rare but devastating malignancy with a proclivity for young adults, disturbingly low survivability, and recalcitrance to therapies. Due to the low incidence, it remains difficult to investigate the mechanism behind CCS. By generating an accurate model system that recapi...2014-12
22 Regulation of C. elegans Sperm Activation by the Protease Inhibitor SWM-1Creation of the next generation by sexual reproduction requires the fusion of male and female gametes. For many species, this entails a sessile oocyte and a highly motile spermatozoon with remarkable ability to sense and migrate through the often structurally and chemically complex reproductive trac...Genetics; Molecular biology; Cellular biology2018
23 Maintenance of Acinar Cell Differentiation by PTF1A Inhibits Pancreatic Cancer InitiationPancreatic cancer remains one of the poorest prognoses in medicine, with limited treatment options and 5-year patient survival of only ~7%. Activating mutations in the Kras proto-oncogene (KrasG12D) are nearly ubiquitous in human pancreatic cancer and are sufficient to initiate precancerous pancreat...Molecular biology; Physiology; Public health; Oncology; Epidemiology2017
24 Polyamine stimulation of antizyme frameshiftingTranslation normally occurs in a linear fashion reading nonoverlapping nucleotide triplets. Alternatively, some genes require translation in two overlapping reading frames. The ability of the ribosome to change to an alternative reading frame is called frameshifting. Frameshifting occurs at a specif...Cell Physiology2006-05
25 Surveying the Genetic Risk Landscape Of Amyotrophic Lateral Sclerosis in The Era of Next-Generation SequencingAmyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is an adult-onset fatal disease in which the upper and lower motor neurons of the body progressively degenerate. Efforts to understand the pathophysiology of ALS over the past two decades have shown that mutations in genes invo...Neurosciences; Genetics; Medicine; Physiology2017
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