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1 Critical Roles of WNT/B-Catenin Signaling During Development of the Retinal Pigment EpitheliumThe RPE is a polarized pigmented epithelial monolayer that is critical for vision and development of the neural retina. Considering its diverse and required roles, it is surprising how little is known about how it develops. Two transcription factors Mitf and Otx2 have been identified. Both are re...Eye; Epithelium2010-04-21
2 Reinstatement of Cocaine-Seeking Behavior Induced by Discrete Sensory Cues and the Associated Immediate Early Gene ExpressionDrug addiction is a serious problem for modern societies worldwide. There are remarkable costs associated with this problem, from the direct costs of the substance abuse treatment and prevention healthcare infrastructure to the less direct implications for the criminal justice system and social w...Cocaine Abuse2010-04-21
3 WNT Signaling and the Establishment of Dorsoventral Retinal PolarityFor our eyes to see, they must establish topographic connections to visual processing centers in the brain, a process critically preceded by patterning of the retina. Gene expression gradients divide the retina along both the dorsal-ventral and the nasaltemporal axes, leading to a retina in which...WNT Genes; Developmental Genetics; Zebra Danios as Laboratory Animals2009-12-21
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