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1 A Computer system for measurement of systolic time intervals.Systolic time internal (STI) tests are a noninvasive technique for evaluation of left ventricular heart function. Manual methods for calculating STI are time consuming, very tedious, and require, lengthy mathematical calculations which are prone to error. A computerized method for measuring STIs u...Heart Beat; Data Processing; Medicine1982-03
2 A Detailed Analysis of Cytochrome C Oxidase Assembly in Yeast MitochondriaCytochrome c Oxidase (CcO) is the terminal enzyme of the mitochondrial respiratory chain. This complex is comprised of subunits encoded by the nuclear and mitochondrial genomes, and requires heme a and copper cofactors for enzyme activity. The assembly pathway of the CcO complex is a coordinated ...2010-02
3 A Novel Player in Mitochondrial Protein Quality ControlProgressive mitochondrial dysfunction is central to the development ofmany human pathologies including cancer, heart failure, and neurodegenerativediseases. Despite numerous studies convincingly connecting these disease states with mitochondrial dysfunction, the mechanistic bases remain elusive. Asi...2011-08
4 A Role for Central Leptin Signaling in Maintaining Myocardial Fatty Acid OxidationLeptin is a hormone produced by adipocytes that activates centralreceptors in the brain and peripheral tissues to decrease appetite and increaseenergy expenditure. Obesity is positively correlated with circulating leptin levels,indicating a state of "leptin resistance" in obese subjects. The relativ...2010-12
5 A comparative study on the physical properties of several ATP-creatine transphosphorylases.An investigation of the physical properties of ATP-creatine transphosphorylase isoenzymes from rabbit, calf, and human has been made. The isoenzymes isolated from the same species differ widely in the net charge and is illustrated by liquid-boundary electrophoresis for the isoenzymes isolated from ...Enzymes; Biochemisty1968-06
6 AKT and mTOR in the HeartInsulin resistance is an independent risk factor for heart disease. In cardiac muscle, PI3K-Akt signaling is persistently activated, despite a reduction in glucose uptake. Given that persistent activation of PI3K and Akt in the heart may be a consequence of hyperinsulinemia in insulin resistant stat...2012-12
7 Adenylate cyclases from homogeneous hepatocytes and Kupffer cells.Previous studies have shown mammalian hepatic adenylate cyclase is stimulated by several compounds including: fluoride ion, guanosine-5-trophosphate (GTP), glucagon, secretin and vasoactive intestinal polypeptide (VIP). In addition to these effectors, prostaglandins of the E series were found to st...Biochemistry; Experiments1974-08
8 Adipocyte Iron Regulates Leptin and Food IntakeIron overload has been proposed to be a component of the insulin-resistance syndrome. On the other hand, dietary iron supplementation is associated with growth and increased appetite in children. We found the concentration of circulating ferritin is associated with low serum adiponectin, the insulin...2015-08
9 Adipocyte Iron Regulation and the Effects of Iron on the Regulation of Adiponectin and LeptinThe incidence and prevalence of obesity and type 2 diabetes are increasingrapidly worldwide. There has been considerable interest in the factors contributing to both obesity and diabetes. While adipocytes were previously thought to be inert storage depots for excess calories, recent studies have dem...2011-05
10 An Investigation of the in vitro metabolism of cortisone by surviving liver slices.Four in vitro incubation experiments have been carried out with cortisone and an attempt was made to isolate and identify any metabolic products formed. All incubations were carried out in a phosphate buffer medium at 35° for a period of four hours. Incubation I was carried out using slices of ra...Metabolism; Phpysiological Effects:1950
11 Any Way You Want It: Pushing the Limits of Chemical Protein SynthesisChemical protein synthesis, via solid-phase peptide synthesis and chemoselective ligation of peptides, is a powerful approach for preparing peptides and proteins. These techniques enable complete atomic control over protein composition with both mechanistic and practical applications for biochemistr...2015-12
12 Assembly of Succinate Dehydrogenase in Mitochondria: Interplay Between Iron-Sulfur Cofactor Insertion and Subunit MaturationSuccinate dehydrogenase (SDH, also known as complex II) is a protein complex located in the inner mitochondrial membrane. SDH has dual roles as a part of both the citric acid cycle and the electron transport chain required for aerobic respiration in eukaryotes. In the past two decades, the structure...2015-12
13 Biochemical and Structural Studies of the Transcription Elongation Factor SPT6 and Its Biding PartnersProduction of a functional protein requires coordination and regulation of many factors that control different cellular processes. One of these factors, Spt6, is a highly conserved nuclear protein that has roles in several facets of gene expression. Spt6 is best known for its ability to chaperone hi...2016-08
14 Biochemical and structural characterization of the human immunodeficiency virus type1 capsid protein and its interaction with human cyclophilin AThe Human Immunodeficiency Virus Type 1 (HIV-1) contains a characteristic cone-shaped structure that surrounds the viral RNA genome at the center of the mature virion. This structure is composed of the viral capsid protein (CA). Capsid also plays a major role early in viral assembly as a domain of t...Host-Virus Relatonships1997-12
15 Biochemical and structural studies of HIV-1 MA membrane interaction and ubiquitin recognitionThis dissertation describes biochemical and structural studies of HIV-1 MA membranes interactions (Chapter 2) and two different conserved ubiquitin binding motifs: the Ubiquitin Interaction Motif (UIM, Chapter 3) and the Npl4 Zinc Finger (NZF, Chapter 4). HIV-1 MA is the N-terminal domain of Gag and...Biochemical; Proteins2003-05
16 Biochemical conversion of progesterone to orchic androgens1. A new system of chromatography has been described which allows resolution of the less polar steroids" such as cholesterol and congeners. It is a reversed phase system utilizing odorless kerosene as the stationary phase, and 60 per cent aqueous n-propanol as the developing phase. It has proved ...Physiology; Biosynthesis1956-06
17 Biochemical studies of retroviral replication and TRIM5α restrictionDuring early stages of infection, HIV-1 and other lentiviruses progress through a series of cytoplasmic events that include capsid uncoating, reverse transcription and formation of the preintegration complex (PIC). In certain primates, the intrinsic immune factor TRIM5α can bind to lentiviral capsi...Molecular biology; Biochemistry; Virology2010
18 Biologically active compounds from Pacific tunicatesTunicates have proven to be a rich source of structurally-diverse metabolites covering a broad spectrum of biological activities. Initial testing of the methanolic extract from three Pacific didemnid tunicates indicated the presence of cytotoxic metabolites. The active compounds were isolated by v...Microbiology1986-12
19 Biophysical characterization of Cox17, the metallochaperone to the mitochondriaCox17 is involved in copper delivery to the cytochrome oxidase complex. Cox17 binds Cu(I) ions via cysteinyl thiolate ligands. Cysteines 23, 24 and 26 of Cox17 are required to produced a functional cytochrome oxidase complex in vivo. These residues appear to be important for Cox17 copper binding, s...Physiology; Cytochrome; Micochondria2001-05
20 Biosynthesis of pancreatic ribonucleaseMethods have been developed for the study of amino acid incorporation into a specific protein under established conditions of net synthesis. The results of these studies have been reported and discussed. Synthesis and storage of the secretory proteins of mouse pancreas have been shown to occur betw...Biosynthesis; Orcinol; Analysis1959-08
21 Cellular Energy Homeostasis: A Nutrient Sensing Kinase and a Mitochondrial Tumor SuppressorObesity, type 2 diabetes and cancer are serious threats to human health and are increasing at an alarming rate. Dysregulation of energy homeostasis, both at the whole body and cellular level, has been implicated in the pathogenesis of those disorders. Cellular energy homeostasis is a delicate bal...2009-08
22 Cellular Host Factors Involved in HIV-1 BuddingIn my dissertation research, I studied the involvement of different cellularpathways in the release of HIV-1 from the host cell, with an emphasis on the ESCRT pathway. The ESCRT pathway comprises a series of protein complexes, including ESCRT-I and ESCRT-III, both of which are required for HIV-1 bud...2011-08
23 Cellular factors and HIV-1 budding.Virus budding is a fission event in which the continuous cell membrane connecting a virion to the cell is severed, creating discrete viral and cellular membranes. Enveloped viruses do not encode their own budding machinery, and must recruit cellular membrane fission proteins to assist in the process...Proteins; AIDS:2003-05
24 Studies of DNA replication in the yeast S; CerevisiaeIn this dissertation I present the contributions that I have made to two separate projects, each concerning different aspects of DNA replication in the yeast Saccharomyces cerevisiae. One project is a study of the Ctf18 protein, a member of the Replication Factor C (RFC) family of DNA polymerase pr...Genetics; Yeast2001-08
25 Changes in preferential hydration of glyceraldehyde 3-phosphate dehydrogenase from yeast brought about by coenzyme bindingThe binding of nicotinamide-adenine dinucleotide to glyceraldehyde 3-phosphate dehydrogenase from yeast was investigated over a temperature and pH range by methods of fluorescence quenching, sedimentation equilibrium, and nuclear magnetic relaxation in order to characterized aspects of the protein ...Yeast; Dehydogenases1972-12
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