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1 Improved method of isolating brucellosis organisms from blood clots utilizing the membrane filterCallister, Dale TaftThe Millipore type of membrane filter was used to culture a Brucella abortus species from artificailly infected rabbit blood clots. Attempts were made to isolate naturally occurring species of these organisms from both human and animal bloods on this filter. The blood clots were treated with both ph...Pathology
2 Immunobiology of murine lyme diseaseYang, LimingIn the mouse model for Lyme disease developed by Dr. Barthold and colleagues, different inbred strains of mice reproducibly display mild, moderate and severe arthritis. C3H mice develop very severe arthritis with the infection of Borrelia burgdorferi and BALB/c mice develop mild arthritis. Previous ...Pathology
3 Effect of earplugs on polysomnographic sleep and description of sleep-disturbing factors in critically ill subjectsWallace, Carrie JaneConsequences of sleep deprivation in critically ill patients may include impaired lymphocyte and granulocyte function, reduction of natural killer cell and lymphokine-activated killer cell number and activity, and delayed weaning from mechanical ventilation. Studies of the impact of sleep-promoting ...Nursing
4 Factors related to use of internet parent support groups by primary caregivers of a child with special health care needsBaum, Lynda S.The purpose of this study was to explore and describe factors related to use of Internet parent support groups (IPSG) by primary caregivers of a child with special health care needs (CSHCN) at home. The Transactional Model of Stress, Coping and Adaptation was used as a framework for developing an In...Nursing
5 Relationship between sociometric status and patient-rated helpfulness in a small informal psychiatric patient groupEvans, Dale Helen FrostThe purpose of this study was to determine if there would be a positive correlation between a person's degree of perceived helpfulness, as evaluated by fellow psychiatric patients, and their sociometric status in the patient group. The study was also designed to ascertain whether psychiatric patien...Nursing
6 Nurse-midwife support at home and success with breast feedingAment, Constance Joyce AbellThe purpose of this study was to investigate the influence of professional support on success with breast feeding. The hypothesis was as follows: the group with teaching and support by nurse-midwife during the postpartum period will demonstrate a greater degree of success with breast feeding than ...Nursing
7 Incubation with dexamethasone increases sphingomyelin in rat fat cell ghostsMurray, Darrell KayThree hour incubations of isolated fat cells from rat epididymal fat pads with 8xlO~°M dexamethasone causes a significant increase in the sphingomyelin content of fat cell ghosts prepared from these cells. Other phospholipids, methylated fatty acids from the phospholipids and cholesterol do not cha...Neurobiology & Anatomy
8 Immunity to histoplasmosis induced in mice by components of Histoplasma capsulatumAnderson, Kenneth LeroyTwenty-three strains of Histoplasma capsulatum were studied. The data indicated that each strain had individual characteristics with regard to: macroscopic appearance of colonies, measurement of spore sizes, relative number of spores, virulence as determined by intravenous LD50 in mice, immunizati...Microbiology
9 Dysregulation of retinoid biosynthesis and metabolism during colon carcinogenesisSandoval, Imelda TumananThe research work presented in this dissertation describes the dysregulation of the retinoid biosynthetic and metabolic pathways accompanying colon carcinogenesis. Colon cancer remains the third leading cause of cancer deaths in the United States. A better understanding of the molecular mechanisms u...Medicinal Chemistry
10 User-centered development of a Web-based preschool vision screening toolTaylor, David P.Amblyopia affects up to 2.5% of the population and is most successfully treated when detected early childhood. It is estimated, however, that fewer than 25% of preschool children in the United States are screened for vision problems by government or private programs. As a cost-effective solution, ...Biomedical Informatics
11 Relationship of emotional intelligence to burnout and job satisfaction among nurses in early nursing practiceFarmer, SuzetteThe Association of Colleges of Nursing has reported that two major contributing factors to the current nursing shortage are job burnout and job dissatisfaction. Given the emotive nature of nursing, this study hypothesized that emotional intelligence would be an individual ability that would influenc...Nursing
12 Zinc finger nuclease-induced double-strand breaks mediate targeted mutagenesis in Caenorhabditis elegansMorton, John JasonZinc finger nucleases (ZFNs) are chimeric proteins composed of a DNA-binding domain comprised of several tandem Cys2His2 zinc fingers and a nonspecific endonuclease domain from the Type IIs restriction enzyme FokI. When expressed in the nematode Caenorhabditis elagans, these molecules bind it's DNA...Biochemistry
13 Adenomatous polyposis coli regulation of WNT signaling via retinoic acid and cycloxygenase-2Eisinger, Annie LouiseGenetic and pharmacological data support the conclusion that cyclooxygenase-2 (COX-2) is negatively regulated by the tumor suppressor adenomatous polyposis coli (APC) and that the loss of APC function and subsequent dysregulation of COX-2 expression promotes turnorigenesis. APC is a negative regulat...Oncological Sciences
14 Steady-state transfer function analysis of portions of the circulatory system using indicator dilution techniquesCoulam, Craig MerrillA digital computer program has been developed whereby the distribution of dye particle transit times across circulatory pathways can be found from recordings of upstream and downstream indicator dilution curves. This distribution, or transfer function is computed from Fourier series representations ...Bioengineering
15 Study of the relationship between sodium ion and hydrogen ion regulation in rat skeletal muscleElsmore, Trudy AnnThe purpose of this study was to elucidate the relationship between the active transport of sodium and the regulation of intracellular pH in rat skeletal muscle. Experiments were conducted both in vivo and in vitro in which Na transport and tissue acid-base balance changed independently and concurr...Pharmacology & Toxicology
16 In vivo nuclear magnetic resonance studies on cerebral energy metabolism and age related isoflurane elimination from rat brainChen, MengIn vivo nuclear magnetic resonance (NMR) was employed to study cerebral energy metabolism under hypoxia, cerebral blood flow (CBF), and isoflurane elimination kinetics as a function of age in rat brain. Three nuclei were involved: 31P for energy metabolism, 2H for monitoring D2O clearance to calcula...Biochemistry
17 Role of platelet activating factor acetylhydrolase in megakaryocytes and yeastFoulks, Jason MarcPlatelet activating factor (PAF) is a synthesized inflammatory phospholipid that signals through a seven-transmembrane G-protein receptor. Oxidation of phospholipids with sn-2 unsaturated fatty acyl residues can fragment the esterified chain forming numerous phospholipids; some are toxic and others ...Pathology
18 Nuclear Magnetic resonance spectroscopy of escherichia coli tRNA (LYS) and the t RNA)LYS)-HIV RNA complexNair, VinodHuman tRNA(Lys,3) is the sole primer of HIV reverse transcription. The interaction between the tRNA and HIV RNA was studied by using E. coli tRNA(Lys) as a model. A reversed phase C4 method was developed for fractionation of tRNAs. This method was used to isolate (15)N labeled tRNA(Lys) from E. col...Medicinal Chemistry
19 Sampling of nitrogen dioxide in a coal dust atmosphereHumfeld, Andrea KarolThe purpose of the study was to determine if coal dust would affect the collection of nitrogen dioxide by an active and two passive personal samplers (TEA tube, Palmes' tube, and DuPont Pro-Tek© badge, respectively). The study was designed to expose an equal number of the three samplers to a mixtu...Family & Preventive Medicine
20 Concentration of acid-fast bacilli with water-insoluble liquidsFukushima, Taira1. A study of the feasibility of the flotation method for concentrating acid-fast bacilli with water-insoluble, volatile liquids was conducted. 2. Commercial grade n-hexane, manufactured by the Phillips Petroleum Company, was found to have the characteristics of the desired solution. 3. The toxic...Pathology
21 Dopaminergic modulation of cultured rat olfactory receptor neuronsGranell, Gricelly VargasThe presence of dopamine D 2 receptors in olfactory receptor neurons (ORNs) suggests that odor sensitivity may be modulated by neurotransmitters at the level of primary sensory neurons. Because the hyperpolarization-activated, I h , channel is present in ORNs, controls cell excitability and is modul...Pharmacology & Toxicology
22 Preanalytic variation in plasma amino acidsChen, MengPlasma amino acid analysis is important for diagnosis and treatment of inborn errors of metabolism, and increasingly for the evaluation of nutritional status and metabolic derangement of other diseases. Its increasing clinical application is a result of the development of highly sensitive and relia...Pathology
23 Contributions of retinoblastoma and p53 to breast carcinogenesisSpancake, Kimberly MichelleThe lifetime risk for a woman to develop breast cancer is 1 in 9 and yet relatively little is known about the early events and conditions that allows for this disease to develop. Tumor suppressor genes are fundamental to the regulation of cellular proliferation and are frequent targets of mutations...Human Genetics
24 Role of APC and retinoid metabolism in gut development and cancer progressionShelton, Dawne NaomiThis work explores the dysregulation of retinoid metabolism in early oncogenesis models, and the role of retinoids in early development of the intestine. APC is a tumor suppressor gene mutated or silenced in -85% of all colorectal cancers. Through the canonical pathway, APC negatively regulates prot...Oncological Sciences
25 Role of MSH6 mutations in North American patients receiving clinical genetic testing for hereditary nonpolyposis colorectal cancerAndersen, MelissaThe relationship of fibrinolytic activity produced by baby hamster kidney (BHK-21) cells to surface properties and growth of the cells has been studied. Hydrolysis of fibrin clots and casein was used to detect cellular protease activity. Cloned, high passage sublines of the BHK-21/C13 cell line we...Pathology
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