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26 The Trigeminal Nerve and Its Central ConnectionsGrant T. Liu, MD. Professor of Neurology, University of Pennsylvania"Because the three divisions of the trigeminal nerve run in close proximity to cranial nerves II, III, IV, and VI, sensory dysfunction in the face may be a symptom in neuro-ophthalmic patients with vision loss and eye movement disorders."
27 Multiple Sclerosis and Related Demyelinating DiseasesLaura J. Balcer, MD, Professor, Department of Neurology, NYU Langone"Destruction of myelin, demyelination, may occur in a variety of diverse inflammatory disorders. Demyelination may result from viral infections and is a prominent feature in the group of disorders known as the demyelinating diseases, of which multiple sclerosis (MS) is perhaps the most well known."
28 Viruses (Except Retroviruses) and Viral Diseases - Part 2Paul W. Brazis, MD, Mayo Clinic; Neil R Miller, M.D., Professor of Ophthalmology, Johns Hopkins University"Viruses are important causes not only of human systemic disease but also of neurologic and visual disease. It is not the purpose of this chapter to consider all known viruses that produce human disease or to consider all diseases produced by those viruses. Instead, we will restrict this chapter to ...
29 Tumors of Maldevelopmental Origin and Related LesionsKarl C. Golnik, MD, Departments of Ophthalmology, Neurology & Neurosurgery, University of Cincinnati & The Cincinnati Eye Institute"Some intracranial lesions result from abnormal development during embryogenesis."
30 Tumors Derived from Hematopoietic Cells and TissueJohn Kerrison, MD, Retina Consultants of Charleston"Hematopoiesis is the orderly process of blood cell proliferation and maturation."
31 Prions and Prion DiseasesEric R. Eggenberger, DO, Mayo Clinic"The prion (pronounced ‘‘pree-on'') diseases are clinically heterogeneous, progressive neurodegenerative disorders that share similar pathologic features, primarily spongiform degeneration of the brain (Figs. 53.1 and 53.2) and are caused by a transmissible agent with biologic properties unlike ...
32 PhacomatosesJohn Kerrison, MD, Retina Consultants of Charleston"Syndromes characterized by hamartomas of the skin, eye, central nervous system (CNS), and other viscera are collectivelycalled phacomatoses (1). These disorders produce significant visual and neurologic disturbances. Although most of these syndromes arise from mutations in single genes inherited in...
33 Paraneoplastic Diseases of Neuro-Ophthalmologic InterestJacobsen, Daniel M; Pomeranz, Howard D"A number of disorders characterized by visual dysfunction, neurologic dysfunction, or both occur in the setting of known or suspected cancers but do not result from the direct effects of the tumor."
34 Retroviruses and Retroviral DiseasesLynn K. Gordon, MD, UCLA"The retroviridae family encompasses a group of viruses in which the replicative life cycle requires reverse transcription of the viral ribonucleic acid (RNA) genome into doublestranded deoxyribonucleic acid (DNA) (1)."
35 SarcoidosisSteven R. Hamilton, MD"Sarcoidosis is a systemic disorder of unknown etiology that has significant ocular, neurologic, and neuro-ophthalmologic manifestations."
36 Diseases Caused by HelminthicMoazami, Golnaz"This chapter considers diseases of neuro-ophthalmologic significance produced by helminths."
37 Myopathies Affecting the Extraocular MusclesPaul N. Hoffman, MD, Departments of Neurology and Ophthalmology, Johns Hopkins Medicine"In this chapter, we consider disorders that produce ocular motor dysfunction from involvement of the extraocular muscles."
38 Fungi and Mycotic DiseasesJoel M. Weinstein, MD"Opportunistic fungal infections are common and continue to increase in frequency and severity as a consequence of the use of immunosuppressive therapy after solid-organ transplantation and for a variety of diseases, particularly cancer, and because of the increasing prevalence of the acquired immun...
39 Disorders of Pupillary Function, Accommodation, and LacrimationAki Kawasaki, MD, PhD, Faculty of Biology and Medicine, University of Lausanne"In this chapter I describe various disorders that produce dysfunction of the autonomic nervous system as it pertains to the eye and orbit, including congenital and acquired disorders of pupillary function, accommodation, and lacrimation."
40 Viruses (Except Retroviruses) and Viral Diseases - Part 1Paul W. Brazis, MD, Mayo Clinic; Neil R Miller, M.D., Professor of Ophthalmology, Johns Hopkins University"Viruses are important causes not only of human systemic disease but also of neurologic and visual disease. It is not the purpose of this chapter to consider all known viruses that produce human disease or to consider all diseases produced by those viruses. Instead, we will restrict this chapter to ...
41 Miscellaneous Tumors of Neuro-Ophthalmologic InterestBenjamin M. Frishberg, M.D."In this chapter we consider several tumors that may produce neuro-ophthalmologic symptoms and signs that do not specifically arise from intradural neural tissue."
42 Lesions Produced by Infections and Inflammations of the Central Nervous SystemBarrett J. Katz, MD, MBA"The central nervous system (CNS) is anatomically protected from invasion by most organisms by structures such as bone, fibrous membranes, and vascular tight junctions (1-3). Nevertheless, once organisms gain entry to the CNS, they proliferate more easily than almost anywhere else in the body."
43 Supranuclear and Internuclear Ocular Motility DisordersZee, David S; Newman-Toker David"In this chapter, we survey clinicopathologic correlations for supranuclear ocular motor disorders."
44 Miscellaneous Diseases of Presumed Infectious EtiologyJacqueline Winterkorn, MD, PhD (1947-2015), Clinical Professor, Department of Ophthalmlogy, Weill Cornell Medicine; Zak, Rochelle S"In this chapter, we discuss diseases of neuro-ophthalmologic interest thought to be caused by infectious agents that have yet to be identified."
45 Protozoa and Protozoal DiseasesWayne T. Cornblath, MD, Clinical Professor, Ophthalmology and Visual Sciences, Professor, Department of Neurology, University of Michigan"Protozoa (from the Latin words proto, meaning ‘‘first,'' and zoon, meaning ‘‘animal'') are acellular or unicellular organisms that are found all over the world in moist soil, fresh water, and oceans."
46 Normal and Abnormal Eyelid FunctionBarry Skarf, MD, PhD, Henry Ford Health System"Disorders of neuro-ophthalmologic significance may affect not only visual sensory, ocular motor, and pupil function but also the function of the eyelids."
47 Anatomy and Physiology of the Cerebrovascular SystemRobert A. Egan, MD, Providence Willamette Falls Medical CenterIn this chapter, the anatomy and physiology of the Cerebrovascular System is discussed.
48 Rickettsiae, Rickettsial-Like Organisms, and the Diseases They ProduceVaphiades, Michael S; Miller, Neil R"Since the last edition of this text was published, advances in molecular biology have resulted in the reclassification of many organisms. Nowhere is this more apparent than in the area of the rickettsiae."
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