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Optic Neuropathy Associated with Folate Deficiency | Karl C. Golnik, MD, Departments of Ophthalmology, Neurology & Neurosurgery, University of Cincinnati & The Cincinnati Eye Institute | Tobacco-alcohol amblyopia is characterized by a symmetric, bilateral optic neuropathy and is thought to be due, in part, to vitamin B-12 deficiency. Most investigators believe the frequently observed concurrent folate deficiency has little functional significance. Although observed by Knox and other... | 19930209_nanos_sciplatform3_03 |