UScholar Works
 
Filters: School Or College: "School of Medicine" Collection: ir_uspace
726 - 750 of 1,125
Number of results to display per page
CreatorTitleDescriptionSubjectDate
726 Normann, Richard A.; Maynard, Edwin M.Neuronal interactions improve cortical population coding of movement directionInteractions among groups of neurons in primary motor cortex (MI) may convey information about motor behavior. We investigated the information carried by interactions in MI of macaque monkeys using a novel multielectrode array to record simultaneously from 12-16 neurons during an arm-reaching task. ...Motor Cortex; Monkey; Population Coding; Movement1999
727 Reimherr, Frederick W.Neuropsychological functioning and OROS® methylphenidate in an Adult Attention-Deficit/Hyperactivity Disorder (ADHD) populationObjective: Neuropsychological tests have been used in attention-deficit/hyperactivity disorder (ADHD) to compare ADHD patients with normal subjects, to assess drug-placebo differences in clinical trials and to identify appropriate medication levels via test dose paradigms. While clinical studies h...Trapeze Interactive Poster2010-03-15
728 Garber, SarahNeurosurgical complications of direct thrombin inhibitors - catastrophic hemorrhage after mild traumatic brain injury in a patient receiving dabigatranDabigatran etexilate is an oral anticoagulant that acts as a direct, competitive thrombin inhibitor. Large randomized clinical trials have shown higher doses of dabigatran (150 mg taken twice daily) to be superior to warfarin in terms of stroke and systemic embolism rates in patients with nonvalvula...2012-01-01
729 Couldwell, William T.Neurosurgical implications of allergic fungal sinusitisObject. Allergic fungal sinusitis (AFS) is a form of paranasal mycosis that often involves bone destruction and extension into the orbit and anterior skull base. Treatment consists of surgical extirpation and a course of corticosteroids. Despite frequent intracranial involvement, AFS is rarely repor...2004
730 Couldwell, William T.Neurosurgical workforce trends in the United StatesObject. The purpose of this study was to evaluate the US neurosurgery workforce by reviewing journal recruitment advertisements published during the past 10 years. Methods. The number of available academic and private neurosurgical staff positions was determined based on recruitment advertisements ...2005-02
731 Frederick, Jeanne M.Neurotransmitter properties of the newborn human retina.Human retinal tissue from a newborn was examined autoradiographically for the presence of highaffinity uptake and localization of the following putative neurotransmitters: dopamine, glycine, GAB A, aspartate, and glutamate. In addition, the dopamine content of this newborn retina was measured by ...Newborn; Human Retina; Neurotransmitter Properties; Photoreceptors1983
732 Zhang, KangNew locus for autosomal dominant stargardt-like disease maps to chromosome 4Stargardt disease (STGD) is the most common hereditary macular dystrophy and is characterized by decreased central vision, atrophy of the macula and underlying retinal-pigment epithelium, and frequent presence of prominent flecks in the posterior pole of the retina. STGD is most commonly inherited a...Haplotypes; Genetic Markers1999
733 Couldwell, William T.No ordinary time, no ordinary men: the relationship between Harvey Cushing and Franklin D. Roosevelt, 1928-1939The authors elucidate the strong personal relationship that developed between Dr. Harvey Cushing and Franklin Delano Roosevelt (FDR) from 1928 to 1939, as manifested in their frequent letters to each other. The relationship was initiated by the marriage of their children. Through his correspondence ...2001
734 Kestle, John R. W.; Walker, Marion L.Noncommunicating spinal extradural arachnoid cyst causing spinal cord compression in a childExtradural arachnoid cysts in the spine are relatively uncommon causes of spinal cord compression in the pediatric population that are thought to arise from congenital defects in the dura mater. Most reports describe such cysts communicating with the intrathecal subarachnoid space through a small de...2006
735 Baehr, WolfgangNoninvasive two-photon imaging reveals retinyl ester storage structures in the eyeVisual sensation in vertebrates is triggered when light strikes retinal photoreceptor cells causing photoisomerization of the rhodopsin chromophore 11-cis-retinal to all-trans-retinal. The regeneration of preillumination conditions of the photoreceptor cells requires formation of 11-cis-retinal in t...Microscopy, Fluorescence; Visual Perception; Membrane Proteins2004
736 Bernstein, Paul S.; Gellermann, WernerNonmydriatic fluorescence-based quantitative imaging of human macular pigment distributions.We have developed a CCD-camera-based nonmydriatic instrument that detects fluorescence from retinal lipofuscin chromophores ("autofluorescence") as a means to indirectly quantify and spatially image the distribution of macular pigment (MP). The lipofuscin fluorescence intensity is reduced at all ret...Cytology; Sensitivity and Specificity2006-10
737 Thomas, Kirk R.; Capecchi, Mario R.Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian. cell nucleiWe have examined the mechanism of homologous recombination between plasmid molecules coinjected into cultured mammalian cells. Cell lines containing recombinant DNA molecules were obtained by selecting for the reconstruction of a functional Neor gene from two plasmids that bear different amber mutat...Animals; Cells, Cultured; DNA Restriction Enzymes; Kinetics1985-01
738 Couldwell, William T.Normal dimensions of the posterior pituitary bright spot on magnetic resonance imaging: Clinical articleObject. The normal pituitary bright spot seen on unenhanced T1-weighted MRI is thought to result from the T1-shortening effect of the vasopressin stored in the posterior pituitary. Individual variations in its size may be difficult to differentiate from pathological conditions resulting in either ab...2014-01-01
739 Couldwell, William T.Norman Dott, Gerard Guiot, and Jules Hardy: key players in the resurrection of transsphenoidal surgeryDeveloped over a century ago, the introduction of the transsphenoidal approach to access lesions of the pituitary gland and sella turcica has transformed the field of neurosurgery, largely due to the work of Oskar Hirsch and Harvey Cushing. Furthermore, its use and modification in the early 1900s wa...2012-01-01
740 Digre, Kathleen B.Not so benign intracranial hypertension.Despite many controversies, intracranial hypertension due to use of doxycycline does occur. Practitioners prescribing the tetracyclic antibiotics should be aware of the syndrome of increased intracranial pressure, and pay particular attention to the ocular fundus for papilloedema. Appropriate referr...Venous Occusion; Venous Hypertension; Tetracycline, Doxycycline; Minocycline2003-03-22
741 Couldwell, William T.; Orlandi, Richard R.; Apfelbaum, Ronald I.Novel closure technique for the endonasal transsphenoidal approach: Technical noteTranssphenoidal microsurgery has been the standard approach to sellar lesions since the repopularization of the technique with modifications by Dott, Guiot, and Hardy. The endonasal transseptal transsphenoidal approach, as introduced by Hirsch, is still commonly used by pituitary surgeons to remove ...2004
742 Baehr, WolfgangNovel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD)PURPOSE: To elucidate the phenotypic and biochemical characteristics of a novel mutation associated with autosomal dominant cone-rod dystrophy (adCORD). METHODS: Twenty-three family members of a CORD pedigree underwent clinical examinations, including visual acuity tests, standardized full-field ERG...Polymorphism, Single-Stranded Conformational; Guanylate Cyclase-Activating Proteins; DNA Mutational Analysis2005
743 Foster, Norman L.Novel insertional presenilin 1 mutation causing Alzheimer disease with spastic paraparesis.A four-generation pedigree exhibiting early-onset autosomal dominant Alzheimer disease (AD) with spastic paraplegia, dystonia, and dysarthria due to a novel 6-nucleotide insertional mutation in exon 3 of the presenilin 1 gene (PS1) is described. Serial examinations, PET scans, and autopsy revealed t...Older people, 80 and over; Membrane Proteins; Neuropsychological Tests2004-05-25
744 Digre, Kathleen B.Novel mechanism for benign essential blepharospasm.PURPOSE: The purpose of this study is to test the hypothesis that the photophobia of benign essential blepharospasm (BEB) is caused by sympathetically maintained pain. METHODS: Nineteen patients with photophobia and BEB were enrolled in an unblinded prospective treatment trial. The intervention was ...Blepharospasm, Autonomic Nerve Block, Blepharospasm, Superior Cervical Ganglion, Lidocaine, Pain1999-11-15
745 Couldwell, William T.; Gillespie, David L.; Jensen, Randy L.Novel model of intracranial meningioma in mice using luciferase-expressing meningioma cellsObject. Meningioma research has been hindered by the inability to sequentially measure intracranial tumor growth in a cost-effective, efficient manner. Recently, the luciferase gene has been transfected into cancer lines to obtain cells that express the luciferase enzyme, which oxidizes luciferin in...2008-01-01
746 Baehr, WolfgangNovel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degenerationPURPOSE: To identify pathogenic mutations in the guanylate cyclase-activating protein 1 (GCAP1) and GCAP2 genes and to characterize the biochemical effect of mutation on guanylate cyclase (GC) stimulation. METHODS: The GCAP1 and GCAP2 genes were screened by direct sequencing for mutations in 216 pat...DNA Mutational Analysis; Mutation, Missense; Electroretinography2004
747 Zhang, KangNovel mutation in the ELOVL4 gene causes autosomal dominant Stargardt-like macular dystrophyPURPOSE. To conduct clinical and genetic studies in a European family with autosomal dominant Stargardt-like macular dystrophy (adSTGD-like MD) and to investigate the functional consequences of a novel ELOVL4 mutationMacular dystrophy; ELOVL4 mutation; Genetics2004
748 Hymas, Weston C.; Hillyard, David R.Novel one step real time RT-PCR Assay for the detection of Enterovirusnteroviruses (EV) are the leading cause of aseptic meningitis in pediatric and adult populations and can be associated with severe disease such as myocarditis, encephalitis, and paralytic poliomyelitis. RT-PCR has rapidly become the diagnostic methodology of choice due to its sensitivity and rapid t...Viruses; Isolation; Purification2005-07-11
749 Hymas, Weston C.; Hillyard, David R.Novel one step real time RT-PCR assay for the detection of Enterovirus, AThis poster describes the development of a novel real time assay that utilizes primers and an Eclipse probe in an overlapping format upstream of the Rotbart amplicon.RT-PCR Assay2005-11-08
750 Kriesel, John D.; Spruance, Spotswood L.; Daynes, Raymond A.Nucleic acid vaccine encoding gD2 protects mice from herpes simplex virus type 2 disease.Nucleic acid vaccinations with plasmids pWW65, containing the sequence for herpes simplex type 2 (HSV-2) gD2, and pRSVnt, lacking the gD sequence, were studied. Groups of mice were immunized with pWW65 alone, pWW65 plus 1,25-dihydroxyvitamin-D3 (D3), or pRSVnt. Clinical disease (vaginitis), serum an...Mice, Inbred BALB C; Plasmids; Viral Vaccines1996
726 - 750 of 1,125