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1 Colicchio, Tiago KuseToward a Better Understanding of the Impact of Information Technology Interventions in Health Care2018
2 Sunada, Grant RogerA Longitudinal Study of Women Coaching Women Through Motivational Interviewing and the Interrelationships Between Depression, Health Behaviors, and Changes in ObesitySome evidence supports the development of holistic interventions that address the overlap between obesity and depression, the both of which have increased burden among women in marginalized communities. Additional understanding about the interrelationships between obesity, health behaviors, and depr...Public health; Mental health; Behavioral sciences2018
3 Matthew Alan SzaniawskiSAMHD1 Activity Underlies Ifn Responses and Sex-Dependent Differences in Macrophage Infection by HIV-1Human Immunodeficiency Virus type 1 (HIV-1) targets immune cells, including CD4+ T cells, macrophages, and dendritic cells (DC). Macrophages are critically important for their contributions to viral propagation and inflammation in vivo during infection, though the current understanding of host-patho...Microbiology; Immunology; Virology2018
4 Smith, Amanda RayInvestigating Human Immunodeficiency Virus Resistance Mechanisms to D-Peptide Entry InhibitorsThe PIE series of D-peptide HIV entry inhibitors, PIE12-trimer and Chol-PIE12-trimer (CPT31), inhibit a wide range of HIV isolates with pM potency while also exhibiting a high barrier to resistance. Here, we show that HIV acquires a primary PIE12 resistance mutation (Q577R/N/K) in both in vitro and ...Virology2018
5 Grafe, Carl JamesMathematical Modeling for Public Health Decision Support During Acute Gastroenteritis OutbreaksAcute gastroenteritis (AGE) outbreaks present a significant challenge to investigating public health officials, who need to know whether point source transmission - such as contaminated food, fomites, or highly infectious individuals - has occurred to respond effectively. However, information on the...Public health; Epidemiology; Information technology2018
6 Li, QingImproved Methods for Next Generation Sequencing-Based Conotoxin DiscoveryCone snails (genus Conus) have attracted scientific interest for the great neuropharmacological potential of their venoms to treat chronic pain, which consist of a complex mixture of peptides known as conotoxins. For discovery purposes, we have carried out a survey of the venom-ducts of 22 Conus spe...Bioinformatics2017
7 Blackburn, Brenna E.The Long-Term Health Effects and Healthcare Costs of Thyroid Cancer Survivors in Population-Based Cohort StudyThyroid cancer patients have one of the highest 5-year survival rates of any cancer at 98%. It also affects a young population as nearly 67% of thyroid cancer patients are diagnosed before age 55. As these survivors are young and leading long lives after cancer diagnosis and treatment, it is importa...Medicine; Public health; Epidemiology2017
8 Wen, JingranPathogenesis of Expanded Polyglutamine Repeats in Neurodegenerative Diseases: Gaining Insight into Protein Folding, Hydrogen Bonding, and Water-Accessibility by Advanced Informatics and SimulationsThe unstable expansion of the polyglutamine (polyQ) tract is a critical factor in the pathogenic pathway of at least ten neurodegenerative diseases, including Huntington's disease, spinal and bulbar muscular atrophy (SBMA), dentatorubral-pallidoluysian atrophy (DRPLA), and seven spinocerebellar atax...Bioinformatics2017
9 Saragsyan, AhotMitochondrial Pyruvate Metabolism Induces Pseudohypoxia and MitophagyMitochondria play a central role in cellular energy metabolism, and they supply most cellular adenosine triphosphate (ATP). During production of ATP, mitochondria also produce reactive oxygen species that could be damaging to mitochondria and to other cellular compartments. To limit and control the ...Molecular biology; Cellular biology; Biochemistry2017
10 Brown, Claudia CisneirosValidation of Beta-Glucosidase Activity Assay in LeukocytesGaucher disease (GD) is an autosomal recessive disorder caused by deficiency of the lysosomal hydrolase glucocerebrosidase (GBA) (EC, required for the degradation of glycosphingolipids. In Gaucher disease, as a result of GBA deficiency, the body is unable to breakdown glucocerebroside, thu...2016-05
11 Bui, Duy Duc anComputer-Aided Approaches to Enhance Systematic Review DevelopmentMedical knowledge learned in medical school can become quickly outdated given the tremendous growth of the biomedical literature. It is the responsibility of medical practitioners to continuously update their knowledge with recent, best available clinical evidence to make informed decisions about pa...2016-05
12 Zhou, ZeminAntigen Presentation Function of Type-1 Diabetes Associated HLA-DQ MoleculesAutoreactive CD4+ T cells initiate the autoimmune disease Type-1 diabetes (T1D). Expression of DQ2, DQ8, and DQ2/8 trans-dimers are highly prevalent in T1D. However, the underlying molecular mechanisms are poorly understood. HLA-DM is essential for editing peptides bound to Major Histocompatibility ...2016-05
13 Jacobs, Jason RichardEvlaution of Computerized Notifications for Laboratory Monitoring of Postliver Transplant Immunosupressive CareFollowing liver transplantation, patients require lifelong immunosuppressive care and monitoring to prevent organ rejection, drug toxicity, and death. Traditionally, transplant centers use paper-based processes that are not scalable and can lead to inefficiencies and deficiencies in information mana...2016-05
14 Olson, Kristofor AksamitMitochondrial Pyruvate Metabolism in Cancer and Stem Cells of the Colon EpitheliumThe study of metabolism is fundamental to understanding the basis of disease. Subtle differences in metabolites, and shunting of molecules from one pathway to another can have profound effects on cellular physiology. In the case of cancer cells this metabolic balance is often severely disrupted. Man...2016-05
15 Jud, Molly ChristineJun Signaling During Drosophila DevelopmentJun N-terminal kinase (JNK) signaling is a key modulator of development and disease in all multicellular organisms. One process in which the consequences of both gain and loss of JNK signaling can be monitored is embryonic dorsal closure (DC) in the fruit fly, Drosophila melanogaster. DC occurs midw...2016-05
16 Soisson, Sean PatrickLong-term, Adverse Cardiovascular, Genitourinary, and Gastrointestinal Outcomes Among Endometrial Cancer Survivors in a Population-based Cohort StudyEndometrial cancer is the second most common cancer among female cancer survivors in the United States. A variety of long-term, adverse health effects have been observed among endometrial cancer survivors but the relationship between endometrial cancer diagnosis and treatment and these outcomes amon...Public health2017
17 Ranade-Kharkar, PallaviUnderstanding Information Needs and Designing Tools for Care Coordination of Children and Youth with Special Health Care Needs (Cyshcn)Inadequate care coordination has been identified as a significant problem in patient care, resulting in diminished satisfaction, increased cost, and reduced quality of care. Comprising an estimated 15.6% (approximately 11 million) of the pediatric population, children and youth with special health c...Bioinformatics; Public health; Disability studies2017
18 Krah, Nathan MichaelMaintenance of Acinar Cell Differentiation by PTF1A Inhibits Pancreatic Cancer InitiationPancreatic cancer remains one of the poorest prognoses in medicine, with limited treatment options and 5-year patient survival of only ~7%. Activating mutations in the Kras proto-oncogene (KrasG12D) are nearly ubiquitous in human pancreatic cancer and are sufficient to initiate precancerous pancreat...Molecular biology; Physiology; Public health; Oncology; Epidemiology2017
19 Kukhareva, PolinaAdvancing Clinical Decision Support (CDS) and Electronic Clinical Quality Measurement (eCQM)Clinical decision support (CDS) and electronic clinical quality measurement (eCQM) are 2 important computerized strategies aimed at improving the quality of healthcare. Unfortunately, computer-facilitated quality improvement faces many barriers. One problem area is the lack of integration of CDS and...Information technology; Health care management2017
20 Grist, Jonathan JeffreyCXCL1/CXCR2 Signaling Axis and Disease Progression in Pre-clinical Animal Models of Multiple SclerosisThe Glu-Leu-Arg (ELR)(+) chemokine C-X-C ligand 1 (CXCL1) is widely known to be involved in the recruitment of neutrophils to sites of inflammation by binding to the receptor C-X-C receptor 2 (CXCR2) expressed on the surface of neutrophils. The role of neutrophils in central nervous system (CNS) dis...Immunology; Neurosciences2017
21 Cahoon, Judd MichaelPreventing and Reversing Blindness: COMP-ANG1 and Endothelial Progenitor Cells as a Novel Therapeutic Approach in Diabetic RetinopathyDiabetes affects 25.8 million people in the United States and its prevalence is expected to triple in the next 20 years. Diabetic retinopathy (DR) affects nearly 30% of people with diabetes and is the leading cause of blindness in the working-age population. Current treatments for DR improve vision ...2015-08
22 Campbell, Michael StephenTools and Training for Genome Annotation and AnalysisThe MAKER genome annotation and curation software tool was developed in response to increased demand for genome annotation services, secondary to decreased genome sequencing costs. MAKER currently has over 1000 registered users throughout the world. This wide adoption of MAKER has uncovered the need...2015-12
23 Chen, Yu-ChanFunctionalizing the Mitochondrial Proteome-Mitochondrial Metabolism, Protein Quality Control and BeyondThis dissertation is to characterize two evolutionarily conserved but uncharacterized mitochondrial proteins using yeast and mammalian cells. The first protein, which we named respiratory supercomplex factor 1 (Rcf1), is required for the assembly of respiratory supercomplexes. Deletion of the RCF1 g...2015-08
24 Duncan, Jeffrey DeanBirth of Identity: Understanding the Value and Policy Considerations of Using Birth Certificates for Identity ResolutionExchanging patient specific information across heterogeneous information systems is a critical but increasingly complex and expensive challenge. Lacking a universal unique identifier for healthcare, patient records must be linked using combinations of identity attributes such as name, date of birth,...2015-12
25 Flygare, StevenComputational Approaches to Biological Data With Applications in Image Analysis, Human Variant Prioritization, and MetagenomicsAdvances in technology have produced efficient and powerful scientific instruments for measuring biological phenomena. In particular, modern microscopes and nextgeneration sequencing machines produce data at such a rate that manual analysis is no longer practical or feasible for meaningful scientifi...2015-08
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