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1 Loftus, Patrick D.Agonist binding of herg K+ channels inhibits epithelial cell extrusion but not apoptosis in MDCK monolayers; providing possibilities to cancer metastasis regulationMetastasis is commonly referred to as cancerous cell movement from an original site to one or more sites elsewhere in the body. When these moving cancerous cells are malignant, an individual's chance of survival is decreased. In order for epithelial cells to move they are detached from the epitheliu...Biomedical Engineering2012-01
2 Johnson, RhiannonThermal modulation of the semicircular canal afferent response in the oyster toadfish, opsanus tauCurrent cochlear implant devices provide limited hearing ability to the deaf through electrical stimulation of the auditory nerve. Recent studies have shown that pulsed infrared (IR) radiation can also be used to stimulate the inner ear neurons and has the potential to be used in prostheses to help ...Biomedical Engineering2012-05
3 Marler, TylerThe role of gangliar plexi in the treatment of atrial fibrillationIntroduction: Gangliar plexi (GP) are bundles of interconnected neurons found embedded in FPs (FPs) surrounding the atria of the heart. The function of these neurons is controversial but they may form a localized control system for the heart and play a role in the induction of atrial fibrillation (A...Atrial fibrillation Treatment; Gangliar plexi2012-05
4 Downs, MelindaModeling conductivity as a function of temperature for CZTS and CZTSe thin film solar cell absorber layersThe goat of this project was to develop an accurate model for the temperature dependent conductivity of CU2ZnSnS4 (elTS) and CU2ZnSnSe4 {ClTSe} thin film solar cell absorber layers. Mathematical models of conductivity and resistivity were derived from both parallel and series combinations of tempera...Solar cells; Thin films2013
5 Lei, Jeffrey KaChonIncreased gluti expression in mouse cardiomyocytes preserves mitochondrial function but is insufficient to attenuate pressure overload-induced contractile dysfunctionLifelong over-expression of GLUT1 transporter in the heart has been shown to preserve contractile function after aortic constriction. However it is unclear whether this protective effect is due to GLUT1 overexpression itself or due to reprogramming of heart metabolism as a result of long-term increa...Bioengineering2013-04
6 Abraham, Jacob Isaac KalunakaaheleOptimization of hydraylic fracturing of tight gas formations in horizontal wellsThe discoveries of significant resources of oil and gas in the Barnett, Bakken, Marcellus, and other shale formations have presented an opportunity for national petroleum independence and possible export in the relatively near future. These formations are considered to be "unconventional" resources ...Hydraulic fracturing2013-04
7 Santos, Jean Paul DytiocoFlight control systems with optimal effector allocation accounting for load constraintsThis paper describes the development of quadratic optimization algorithms to be used in flight control systems; such optimization algorithms aid in distributing control efforts among available actuators to produce forces to keep aircraft stable and in flight. With the advancement of computing power,...Flight control; Algorithms2013-05
8 Uchida, Kimberly AkimiPost-translational regulation of the tumor suppressor PDCD4Expression of the tumor suppressor Programmed cell death 4 (PDCD4) is correlated with better survival outcomes in several types of cancer. When PDCD4 is coexpressed with protein arginine methyltransferase 5, however, this trend does not hold true, suggesting that PDCD4 methylation is involved in the...Tumor suppressor proteins - Regulation2013-12
9 Ruan, TingEndogenous ceramide contributes to cardiovascular complications in Type II diabetes by decreasing the association between PP2A and I2PP2ACardiovascular complications are the leading cause of death in individuals with conditions associated with insulin resistance, e.g. type 2 diabetes, diet-induced obesity. In patients with type 2 diabetes, cardiovascular complications are 2-4 times more prevalent. One common cardiovascular complicati...Ceramides - Physiological effect; Diabetic angiopathies2014
10 Freckleton, K. BeauSarrus-based passive mechanism for rotorcraft perchings: Structural design and mass optimizationCurrent quad-rotors provide excellent maneuverability and opportunity for data collection in large scale areas such as agriculture, but lack the capability to maintain flight for an extended period of time. This is primarily due to a lack of energy supply, requiring operators to replace the battery ...Drone aircraft; Drone aircraft -- Control systems; Sarrus2014-12
11 Anjewierden, ScottAutomated kinematic analysis of pre-pluse inhibition in larval zebrafishAnimals differentially ignore or attend to sensory information depending on their immediate environment. A significant example of this phenomenon is audiomotorpre-pulse inhibition (PPI), in which the startle response to a loud noise is suppressed by a preceding stimulus of lower intensity. This a...Zebra danio - Development; Kinematics - Research; Kinematic parameters; Swim kinematics; Pre-pulse inhibition2014-12
12 Hahn, CarinaPlasmonically active silver nanowire structures for energy storage applicationsCurrently, there are no sustainable solutions available to meet the increasing demand for grid scale energy storage. Solar to fuel conversion has the potential to curb our dependence on natural gas and costly storage technologies by recycling waste products into chemical fuels. A realistic device mu...Nanowires; Energy storage; Plasmons (Physics)2015-04
13 Black, Taylor MadisonImpacts of Tobacco Smoke Exposure and Outlier Body Mass Indices on Pediatric Asthma OutcomesThere are seven million children in the United States impacted by asthma [1]. When assessing the severity of a child's asthma, it is important to take into account risk factors known to affect child hood asthma. Two such risk factors that are modifiable include parental tobacco smoke exposure (TSE)...Asthma - Child; Tobacco smoke - Health aspects - United States2015-05
14 Beus, ZacharyPower system stabilizerThe goal of this project, part of the Power Industry Consortium, was to design a power system stabilizer for a small grid-connected three phase synchronous generator. Power System Stabilizers control the excitation of synchronous generators to reduce lowfrequency oscillations on the grid and increas...Voltage regulators; Power system stabilizers2015-05
15 Waller, Rosalie G.Exome sequence comparison of seventy-seven multiple myeloma cases identifies potential risk allelesMultiple Myeloma (MM) is a heritable cancer of plasma cells with poor prognosis. Although a few genomic risk-loci have been identified for MM, no risk variants have been published that explain MM heritability. We hypothesize MM heritability is due to rare germ-line variants that can be discovered th...Multiple myeloma -- Genetic aspects; Exomes; Exome sequence; Risk alleles2015-05
16 Khoury, MarkMuscle activity changes due to immobilization and partial weight bearing of the lower legTibial fractures account for half a million hospitalizations per year. Although clinical treatment of tibial fractures requires immobilization of the affected limb and partial weight bearing (PWB) prescriptions, the effects of this treatment protocol on gait and muscle activity have not been studied...Muscles -- Physiology; Tibia -- Wounds and injuries; Muscle activity; Partial weight bearing2015-05
17 Javdan, ShwanTargeted HPMA copolymer-gemcitabine conjugates for the treatment of ovarian carcinomaEach year in the United States, over 14,000 women die from ovarian cancer. Anthracyclines-a class of chemotherapeutics-have long been the primary treatment for this and many other cancers, yet they often leave patients with cardiotoxicity, hepatotoxicity, and a number of other adverse effects. Polym...Ovaries -- Cancer -- Treatment; Polymeric drug delivery systems; Polymer-drug conjugates; pHPMA2015-12
18 Clark, CalliStudying hypothetical electromagnetic earthquake precursors using a global finite-difference time-domain modelElectromagnetic (EM) precursors may be detectable by satellites and ground-based stations before large earthquakes strike and destroy entire cities. However, earthquakes are near impossible to predict as the physics of earthquake precursors is still poorly understood. This paper reports a global...earthquake prediction - Research; Seismology - Research; Earthquake hazard analysis; Earthquake precursors; Electromagnetic signals; Ionospheric physics; Finite-difference time-domain model2016-04
19 Flach, BrianExamining the effects of whisker trimming on mouse brain cell growthHoxb8 microglia are a particular breed of scavenger cells in the brain which have been related to obsessive compulsive disorder (OCD)-like behavior among other behavioral disorders. These cells have been found to reach full maturity during a period of neurological development known as the critical ...Obsessive-compulsive disorder - Research; Microglia - Research; Mice as laboratory animals - Research; Whiskers; Scavenger cells; Hoxb8 microglia2016-04
20 Lietzke, StephanieRemoval of endotoxins from recombinant antithrombinEndotoxins (also known as lipopolysaccharides or ETs) are a pyrogenic byproduct of the breakdown of gram-negative bacterial cell-walls, such as E. coli. They cause fever and septic shock in humans, and are therefore highly regulated by the FDA and USP. ETs are a common contaminant in recombinant pr...Endotoxins - Research; Antithrombins - Therapeutic use; Sheep as laboratory animals - Research; endotoxin removal; Angiogenesis2016-04
21 Matheson, KristofferDesign of a novel x-ray CT in situ experiment for imaging 3D deformation of aluminum foam materialsOpen-cell metallic foams show excellent potential for lightweight load-bearing structural applications, electrodes in energy-storage devices, biomedical implants, and heat exchangers, to name a few. A key aspect in efficient and streamlined deployment of aluminum foams for these applications lie...Foamed materials - Testing; Tomography - Research; Lightweight materials - Research; X-ray computed tomography; Aluminum foam materials; Load frame2016-04
22 Palmieri, NikoleValidation of a nonlinear optimization algorithm for reconstruction of diffused imagesLiving tissue is a diffusive light-scattering medium, preventing traditional fluorescence microscopy from being used as a diagnostic imaging modality. To determine microscopy from being used as a diagnostic imaging modality. To determine whether the nonlinear optimization algorithm developed for C...Diagnostic imaging; Mathematical optimization; Image processing; Diffusion distance; Computational Cannula Microscopy; Nonlinear optimization; MATLAB2016-04
23 Newton, JamesSocial behaviors in the developing Danio Rerio larva and adult DanionellaLarval zebrafish (Danio rerio) in most respects excel as an animal model in the study of neural networks, due to their small size and optical transparency. These traits permit optogenetic manipulation and live neuronal imaging of the entire brain, which when paired with behavioral analysis, have pot...Zebrafish (Zebra danio) - behavior; Zebrafish - embryology; Zebrafish - physiology2016-04
24 Sharma, KapilAnalyzing the relationship between PDM2 and B-catenin proteins in human cancersTumorigenesis is promoted by the manipulation of several co-factors and pathways, in which PKM2 and P-catenin proteins play a significant role in a variety of cancers. New research states that these two hegemonic cancer proteins directly bind with each other and may provide a new angle for cance...Pyruvate kinase - Research; Tumorigensis - Research2016-04
25 Davidson, OliviaUtilizing synthetic biology to improve platelet transfusion outcomesPlatelets are essential to blood clotting. Due to a high risk of bacterial infection, donor platelets have short shelf -lives. As a result, being able to maintain a constant supply of platelets in vitro would be clinically valuable. This could be accomplished by using synthetic biology to guide stem...Blood platelets - Transfusion - Research; Stem cells - Therapeutic use; Synthetic biology; Hematopoietic stem cells; Erthropoientin2016-05
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