Filters: Publication Type:"journal article" Department:"Bioengineering" Collection:"ir_uspace" Type:"Text"
| Title | Creator | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |  | Selective stimulation of peripheral nerve fibers using dual intrafascicular electrodes | Horch, Kenneth W. | We have studied activation of newe fibers by pairs of Pt-Ir wire electrodes implanted within single fascicles of the nerve innervating the gastrocnemius muscle in cats. The purpose of this study was to determine if these intrafascicular electrodes can activate nerve fibers in different fascicles... | Functional electrical stimulation; Intrafascicular stimulation; Silicon electrode array | 1993 |
| 2 |  | Separation of action potentials in multiunit intrafascicular recordings | Horch, Kenneth W. | Classification of action potentials in multiunit recordings was based on the use of various types of features to uniquely characterize action potentials from different cells. We compared classification results obtained using three types of descriptive features: digitized data points, amplitude and ... | Long-term implantable intrafascicular electrodes; Nerve recordings; Simulated neural data | 1992 |
| 3 |  | Changes in primary afferent depolarization of sensory neurones during peripheral nerve regeneration in the cat | Horch, Kenneth W. | I. Micro-electrode recordings were made from normal and regenerating sural nerve fibres in cats. Increases in the excitability of the central terminals of these fibres after conditioning stimulation of other sural nerve fibres were taken as evidence for primary afferent depolarization. 2. At all... | Micro-electrode recording; Nerve regeneration; Primary afferent depolarization | 1981 |
| 4 |  | Processing of adenovirus 2-induced proteins | Gesteland, Raymond F. | Analysis of (35)S-methionine-labeled extracts of adenovirus 2-infected KB cells revealed 22 virus-induced polypeptide components. Most proteins of the virion were easily detected in extracts of whole cells labeled for short periods between 15 and 30 h after infection; however, several virion compone... | Adenoviridae; Viral Proteins; Protein Precursors; Methionine; Mouth Neoplasms | 1973 |
| 5 |  | Silicon-based, three-dimensional neural interface: manufacturing processes for an intracortical electrode array | Normann, Richard A.; Campbell, Patrick K.; Jones, Kelly E.; Huber, Robert J.; Horch, Kenneth W. | A method has been developed for the manufacture of a "three-dimensional" electrode array geometry for chronic intracortical stimulation. This silicon based array consists of a 4.2 x 4.2 x 0.12 mm thick monocrystalline substrate, from which project 100 conductive, silicon needles sharpened to facilit... | Electric Stimulation; Electrodes, Implanted; Sensory Cortex; Intracortical Electrode Array | 1991 |
| 6 |  | Simian virus 40-specific polypeptides in Ad2+ND4- infected cells | Gesteland, Raymond F. | A comparison of the proteins synthesized in human cells at late times after infection with adenovirus (Ad2) and with the adeno-simian virus 40 (SV40) hybrid viruses revealed polypeptides of 30,000 and 92,000 molecular weight specific for the hybrid viruses Ad2+ND1 and Ad2+ND4, respectively. Cell-fre... | Molecular Weight; Peptide Biosynthesis; RNA, Messenger; Viral Proteins | 1976 |
| 7 |  | Robust estimation of fetal heart rate variability using Doppler ultrasound. | Varner, Michael W.; Clark, Edward B.; Fernando, Kumari L.; Mathews, V. John | This paper presents a new measure of heart rate variability (HRV) that can be estimated using Doppler ultrasound techniques and is robust to variations in the angle of incidence of the ultrasound beam and the measurement noise. This measure employs the multiple signal characterization (MUSIC) algori... | Prenatal Ultrasonography; Fetal Heart Rate; Blood Flow Velocity; Algorithms | 2003-08 |
| 8 |  | 100 electrode intracortical array: structural variability | Normann, Richard A.; Campbell, Patrick K.; Jones, Kelly E. | A technique has been developed for fabricating three dimensional "hair brush" electrode arrays from monocrystalline silicon blocks. Arrays consist of a square pattern of 100 penetrating electrodes, with 400 microns interelectrode spacing. Each electrode is 1.5mm in length and tapers from about 100 m... | Microelectrode arrays; Stimulation; Micromachining | 1990 |
| 9 |  | Mobility performance with a pixelized vision system | Normann, Richard A.; Horch, Kenneth W.; Cha, Kichul | A visual prosthesis, based on electrical stimulation of the visual cortex, has been suggested as a means for partially restoring functional vision in the blind. The prosthesis would create a pixelized visual sense consisting of punctate spots of light (phosphenes). The present study investigated the... | Visual Prosthesis; Mobility; Phosphene Simulator | 1992 |
| 10 |  | Signal integration at the pedicle of turtle cone photoreceptors: an anatomical and electrophysiological study | Normann, Richard A.; Kolb, Helga; Lasater, Eric M. | The morphology of the axon which connects the cell body and pedicle of turtle cone photoreceptors was studied by light and electron microscopy. The axon which contains numerous synaptic vesicles, some endoplasmic reticulum, and a few cisternae is basically filled with cytoplasm. The length of the ax... | Cone Photoreceptor, Voltage Clamp; Isolated Cells; Input Resistance; Cell Body-Pedicle Coupling | 1989 |
| 11 |  | Functional reorganization of primary visual cortex induced by electrical stimulation in the cat. | Normann, Richard A. | Compared to the high degree of plasticity observed in a juvenile, mature sensory cortices have long been held to be immutable but, recently, researchers have suggested some plasticity persists in the mature cortex. Cortical reorganization has particular saliency to the development of a cortically ba... | Cat; Electrophysiology; Phosphene; Plasticity; Receptive Field; Striate Cortex | 2005 |
| 12 |  | Encoding mechanisms for sensory neurons studied with a multielectrode array in the cat dorsal root ganglion | Normann, Richard A.; Shoham, Shy | Recent advances in microelectrode array technology now permit a direct examination of the way populations of sensory neurons encode information about a limb's position in space. To address this issue, we recorded nerve impulses from about 100 single units simultaneously in the L6 and L7 dorsal root ... | Sensory; Encoding; Multielectrode; Dorsal Root Ganglion; Cutaneour; Muscle | 2004 |
| 13 |  | Three-dimensional architecture for a parallel processing photosensing array | Normann, Richard A.; Johansson,Torbjorn; Abbasi, Masoud; Huber, Robert J. | A three-dimensional architecture for a photosensing array has been developed. This silicon based architecture consists of a 10 x 10 array of photosensors with 80 microns diameter, through chip interconnects to the back side of a 500 microns thick silicon wafer. Each photosensor consists of a 300 x 3... | Retina; Optics; Silicon; Photosensing | 1992 |
| 14 |  | Neural interface for a cortical vision prosthesis | Normann, Richard A.; Maynard, Edwin M. | The development of a cortically based vision prosthesis has been hampered by a lack of basic experiments on phosphene psychophysics. This basic research has been hampered by the lack of a means to safely stimulate large numbers of cortical neurons. Recently, a number of laboratories have developed a... | Neuroprosthetics; Artificial Vision; Electrode Arrays; Multielectrode Recordings; Biocompatibility | 1999 |
| 15 |  | Selective motor unit recruitment via intrafascicular multielectrode stimulation | Normann, Richard A.; Clark, Gregory A.; McDonnall, Daniel | Recruitment of force via independent asynchronous firing of large numbers of motor units produces the grace and endurance of physiological motion. We have investigated the possibility of reproducing this physiological recruitment strategy by determining the selectivity of access to large numbers of ... | Funtional Neuromuscular Stimulation; Microelectrode Array; Neuroprosthesis; Intrafascicular Multielectrode Stimulation; Cats | 2004 |
| 16 |  | Effects of GABA and related drugs on horizontal cells in the isolated turtle retina | Normann, Richard A. | The role of GABA in the outer plexiform layer of the turtle retina has been examined by intracellular recordings from L- and C-type horizontal cells in the isolated retina preparation. GABA (1-5 mM) slightly depolarized the L-type horizontal cells, reduced the amplitude of their photoresponses, and ... | Retina; Horizontal Cells; Synapse; Negative Feedback; GABA; Turtle | 1990 |
| 17 |  | Pattern of protein synthesis in monkey cells infected by simian virus 40 | Gesteland, Raymond F. | After infection of several permanent monkey cell lines by simian virus 40 (SV40), four additional protein bands can be detected by simple sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell extracts. These bands appear only after the onset of viral deoxyribonucleic acid (DNA) syn... | Monkeys; Simian virus 40; Peptides; DNA, Viral/biosynthesis | 1972 |
| 18 |  | Crystallization of the MS2 translational repressor alone and complexed to bromouridine | Gesteland, Raymond F.; Krapcho, Karen J.; Talbot, Phil; Thulin, Craig | The coat protein from the MS2 bacteriophage plays a dual role by encapsidating viral RNA and also by binding RNA as a translational repressor. In order to study the isolated dimer in a conformation not influenced by capsid interactions, a mutant molecule was crystallized that is defective in capsid ... | Crystallization; RNA Bacteriophage; RNA Hairpin; Translational Repressor | 1995 |
| 19 |  | Characterization of lysozyme messenger and lysozyme synthesized in vitro | Gesteland, Raymond F. | In vitro systems for protein systhesis have been in wide use for about 10 years. In most of the early work protein synthesis was measured by following the incorporation of radioactive amino acids into acid precipitable material. This test cannot distinguish between the synthesis of complete, activ... | Lysozyme Messenger; Lysozyme Synthesized; Protein Synthesis | 1969 |
| 20 |  | Efficient shine- Dalgarno sequence but not translation is necessary for LacZ mRNA stability in Escherichia coli | Gesteland, Raymond F.; Weiss, Robert B. | The 5' ends of many bacterial transcripts are important in determining mRNA stability. A series of Shine-Dalgarno (SD) sequence changes showed that the complementarity of the SD sequence to the anti-SD sequence of 16S rRNA correlates with lacZ mRNA stability in Escherichia coli. Several initiation c... | Protein Biosynthesis; Ribosomes; Escherichia coli; Shine-Dalgarno Sequence | 1994 |
| 21 |  | Automated film reader for DNA sequencing based on homomorphic deconvolution | Gesteland, Raymond F.; Ives, Jeffrey T.; Stockham, Thomas G. | An automated reader for electrophoresis based DNA sequencing methods is described that provides fast and accurate sequence determination. Digitized sequencing lanes are processed with homomorphic blind deconvolution in preparation for peak detection, interlane alignment, peak refinement and base cal... | Sequence Analysis; Electrophoresis; Automated Film Reader; Homomorphic Deconvolution | 1994 |
| 22 |  | Translation of Rl7 RNA fragments | Gesteland, Raymond F. | Examination of the events during infection of cells by RNA phages reveals phemonomena that are surprisingly complex for a virus that has only enough information to code for three to four proteins. The coat protein is synthesized at a rapid rate through most of the infectious cycle making it the pre... | Electrophoresis; RNA, Messenger; Peptide Biosynthesis; Kinetics | 1969 |
| 23 |  | Effects of weak extremely low frequency magnetic fields on calcium/calmodulin interactions. | Hendee, Shonn P.; Faour, Fouad A.; Christensen, Douglas A.; Patrick, Baharah; Durney, Carl H.; Blumenthal, Donald K. | Mechanisms by which weak electromagnetic fields may affect biological systems are of current interest because of their potential health effects. Lednev has proposed an ion parametric resonance hypothesis (Lednev, 1991, Bioelectromagnetics, 12:71-75), which predicts that when the ac, frequency of a c... | Electromagnetic Fields; Calcium-binding Proteins; Lednev's Theory | 1996-06 |
| 24 |  | Virtual histology of transgenic mouse embryos for high-throughput phenotyping. | Hansen, Mark S.; Healy, Lindsey J.; Johnson, Christopher R.; Capecchi, Mario R.; Keller, Charles; Jones, Greg M. | A bold new effort to disrupt every gene in the mouse genome necessitates systematic, interdisciplinary approaches to analyzing patterning defects in the mouse embryo. We present a novel, rapid, and inexpensive method for obtaining high-resolution virtual histology for phenotypic assessment of mouse ... | Forkhead Transcription Factors; Paired Box Transcription Factors | 2006 |
| 25 |  | Cell-free synthesis of herpes simplex virus proteins | Gesteland, Raymond F. | Polyribosomes isolated from herpes simplex virus type I (HSV-1)-infected cells have been used to program a eucaryotic cell-free translation system. At least 10 HSV-specific polypeptides, with apparent molecular weights of 25,000 to 160,000, are synthesized by wild-type HSV-infected polyribosomes. Po... | Viral Proteins; Herpes Simplex; Peptide Biosynthesis; Thymidine Kinase | 1977 |