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1 Varner, Michael W.Elevated second-trimester maternal serum hCG: a marker of inadequate angiogenesis.OBJECTIVE: To measure angiogenin, a potent inducer of neovascularization and interleukin-6, as an indicator of acute inflammation, in second-trimester amniotic fluid of patients with elevated maternal serum hCG. METHODS: In this case-control study, 20 patients with elevated maternal serum hCG (at le...Angiogenesis Inducing Agents; Interleukin-6; Pregnancy Complications; hCG1998-04
2 Moon, Anne M.TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-Mammary SyndromeTBX3 is a member of the T-box family of transcription factors with critical roles in development, oncogenesis, cell fate, and tissue homeostasis. TBX3 mutations in humans cause complex congenital malformations and Ulnar-mammary syndrome. Previous investigations into TBX3 function focused on its acti...2014-01-01
3 Varner, Michael W.Abnormal pregnancy sonogram: selective indication for fetal karyotype.The inability to make a definitive diagnosis in the fetus with a sonographically identified abnormality often results in parental and physician uncertainty. An antenatal chromosome evaluation could resolve this uncertainty. Forty-one fetuses with an abnormal ultrasound examination were tested for ka...Chromosome Disorders; Pregnancy; Karyotyping; Abnormalities; Amniocentesis1987-01
4 Varner, Michael W.Systemic lupus erythematosus.Systemic lupus erythematosus is an autoimmune disease of unresolved cause afflicting predominantly women in their childbearing years. Speculation exists as to the relative roles of viruses, histocompatibility loci such as HLA-DR3, and estrogenmediated decreases in suppressor cell function. Whateve...Systemic Lupus Erythematosus; Pregnancy Complications1983-09
5 Varner, Michael W.; Jackson, G. MarcSevere pulmonary hypertension in pregnancy following successful repair of ventricular septal defect in childhood.BACKGROUND: Because of advances in surgical repair, an increasing number of women born with structural cardiac disease now live to reproductive age. Patients treated successfully in childhood are followed for varying periods of time, then may be lost to follow-up or told that no follow-up is necessa...Pregnancy Complications, Cardiovascular; Heart Septal Defects, Ventricular; Hypertension, Pulmonary1993-10
6 Hansen, Mark S.; Coffin, Cheryl M.; Capecchi, Mario R.Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin.To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do...Neuroprogenitor; Embryogenesis2004-11-01
7 Dolcourt, John L.; Hales, Joseph W.Use of internet searches for physician learningINTRODUCTION In 2005 the American Medical Association (AMA) approved the structure for awarding continuing medial education (CME) credit to physicians searching the Internet for answers to point-of-care related questions. Previous investigations of how physicians use the Intenet have relied on...Trapeze Interactive Poster2009
8 Gibbs, Katie Bernice; Frazer, John K.otg, a heritable T-cell malignancy in zebrafish that exhibits apoptosis resistanceOtg (oscar the grouch), a line of zebrafish identified with a T cell malignancy pseudoposition, has a recessive inheritance pattern with approximately 50% penetrance in presumed homozygotes (m/m). After breeding otg with a wild-type lck::eGFP fish to create obligate heterozygotes (+/m), and then in...otg; Oscar the grouch zebrafish; Apoptosis resistance; T cell malignancy; Pseudoposition; Trapeze Interactive poster2010-03-15
9 Varner, Michael W.Blood transfusion and cesarean delivery.OBJECTIVE: To evaluate risks for intraoperative or postoperative packed red blood cell transfusion in women who underwent cesarean delivery. METHODS: This was a 19-university prospective observational study. All primary cesarean deliveries from January 1, 1999, to December 31, 2000, and all repeat c...Blood Transfusion; Postpartum Hemorrhage; Pregnancy Complications; Anemia2006-10
10 Wen, Ming; Van Duker, Heather; Olson, Lenora MarySocial contexts of regular smoking in adolescence: towards a multidimensional ecological modelUsing data from the Longitudinal Study of Adolescent Health (Add Health), this study investigates factors at the individual, family, peer, school, neighborhood, and state levels that are important for subsequent adolescent cigarette regular smoking after controlling for the baseline smoking behavio...Adolescent smoking; Social capital; Family; Neighborhood; School; Teenagers; Teenage smoking2006-09-19
11 Varner, Michael W.Human placental lactogen and other placental proteins as indicators of fetal well-being.The purpose of this article will be to review the role of hPL and the newer hormones as indicators of fetal well-being.Human Placental Lactogen; Pregnancy Proteins; Indicators of Fetal Well-Being1982-12
12 Varner, Michael W.Decision-to-incision times and maternal and infant outcomes.OBJECTIVE: To measure decision-to-incision intervals and related maternal and neonatal outcomes in a cohort of women undergoing emergency cesarean deliveries at multiple university-based hospitals comprising the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units N...Cesarean Section; Fetal Distress; Outcome Assessment; Fetal Distress2006-07
13 Varner, Michael W.; Digre, Kathleen B.Cranial magnetic resonance imaging in eclampsia.Although the precise neuropathologic basis for eclamptic convulsions remains unclear, intracranial hemorrhage is frequently associated with fatal cases. Magnetic resonance imaging (MRI) is a recently developed neuroimaging technique that appears superior to other processes for defining intracranial ...Eclampsia; Brain Edema; Cranial Magnetic Resonance Imaging1987-09
14 Varner, Michael W.Spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy.OBJECTIVE: We sought to estimate the rate of spontaneous resolution of asymptomatic Chlamydia trachomatis in pregnancy and to evaluate factors associated with its resolution. METHODS: A cohort of women enrolled in a large multicenter randomized bacterial vaginosis antibiotic trial (metronidazole ver...Pregnancy; Chlamydia Trachomatis; Sexually Transmitted Diseases2005-03
15 Varner, Michael W.Physiologic changes in pregnancy: surgical implications.Pregnancy has measurable effects on essentially every organ system in a woman's body. An understanding of these changes is vital for determining what is normal or abnormal in a pregnant woman. These changes frequently alter symptoms and signs of surgical diseases during pregnancy. In addition, ma...Pregnancy; Physiologic Changes; Surgical Implications1994-06
16 Varner, Michael W.Serial salivary estriol to detect an increased risk of preterm birth.OBJECTIVE: To evaluate serial measurements of salivary estriol (E3) to detect increased risk of spontaneous preterm labor and preterm birth. METHODS: A masked, prospective, multicenter trial of 956 women with singleton pregnancies was completed at eight United States medical centers. Saliva was coll...Estriol; Preterm Birth; Spontaneous Preterm Labor2000-10
17 Varner, Michael W.Association of obesity with pulmonary and nonpulmonary complications of pregnancy in asthmatic women.OBJECTIVE: To evaluate whether maternal obesity is associated with pulmonary and nonpulmonary pregnancy complications in asthmatic women. METHODS: This is a secondary analysis of the prospective cohort Asthma During Pregnancy Study. Asthma patients were classified as having either mild or moderate t...Asthma; Body Mass Index; Pregnancy Outcome; Lung Diseases2006-07
18 Varner, Michael W.Reduction in amniocentesis risks using a real-time needle guide procedure.Rates of complications associated with a second trimester genetic amniocentesis were studied in 918 patients, and complete infant follow-up was obtained. In 903 singleton pregnancies and 15 twin gestations, the procedure was performed under continuous sector scanning guidance through an attached nee...Amniocentesis; Ultrasonography; Pregnancy2007-01-25
19 Moon, Ann M.; Capecchi, Mario R.Fgf8 is required for outgrowth and patterning of the limbs.The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we rep...Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm2000-12-26
20 Varner, Michael W.; Lyon, Joseph L.; Alder, Stephen C.; Ellis Simonsen, Sara M.Effect of grand multiparity on intrapartum and newborn complications in young women.OBJECTIVE: To examine the effect of high parity on complications in young women, aged 18-34 years. METHODS: Seven years of Utah birth certificate data were reviewed (1995-2001). Young nulliparas and primiparas were compared with young grand and great grand multi-paras by using logistic regression. Y...Infant, Newborn; Parity; Pregnancy; Risk Factors; Obstetric Labor Complications2005-09
21 Varner, Michael W.; Hatasaka, Harry H.Recurrent pregnancy loss.Recurrent pregnancy loss is a frustrating clinical dilemma for both patients and physicians because, in most cases, causes are nebulous and few treatments with proven benefit can be offered. Involved, expensive tests have frequently been proposed and their use has often filtered into clinical practi...Recurrent Pregnancy Loss; Uterus/abnormalities; Chromosome Disorders; Abortion, Habitual1994-06
22 Moon, Ann M.; Capecchi, Mario R.Roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth.Although numerous molecules required for limb bud formation have recently been identified, the molecular pathways that initiate this process and ensure that limb formation occurs at specific axial positions have yet to be fully elucidated. Based on experiments in the chick, Fgf8 expression in the in...Animals; Apoptosis; Forelimb; Gene Expression Regulation, Developmental; High Mobility Group Proteins; Hindlimb; In Situ Hybridization; Mesoderm; Mice, Mutant Strains; Trans-Activators2004-09
23 Varner, Michael W.Cerebral vasculopathies masquerading as eclampsia.Obstetricians know that preeclampsia-eclampsia is a syndrome and is a final common pathway for multiple causes. It is also possible that other conditions, not always directly related to pregnancy, can mimic preeclampsia-eclampsia. One such entity is cerebral vasculopathy, an entity characterized b...Cerebrovascular Disorders; Eclampsia; Puerperal Disorders2006-02
24 Varner, Michael W.Human placental lactogen: a predictor of perinatal outcome?Serial human placental lactogen (hPL) determinations were performed on 806 women with normal and abnormal pregnancies late in the pregnancy. These results were not reported to the clinicians involved. For the study population as a whole, low hPL levels did not effectively predict those adverse perin...Infant, Newborn; Placental Lactogen; Pregnancy; Prenatal Diagnosis1979-08
25 Varner, Michael W.Elevations of amniotic fluid macrophage inflammatory protein-1 alpha concentrations in women during term and preterm labor.OBJECTIVE: To determine whether elevated concentrations of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in amniotic fluid (AF) are related to term and preterm labor. METHODS: Amniotic fluid was obtained from women from five different clinical situations: 1) term cesarean delivery, no labor ...Amniotic Fluid; Macrophage Inflammatory Protein-1; Obstetric Labor, Premature1996-01
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