Filters: Department: "Neurosurgery" Collection: "ir_uspace" Type: "Text" School Or College: "School of Medicine"
| Creator | Title | Description | Subject | Date | ||
|---|---|---|---|---|---|---|
| 1 |
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Huang, Lin Eric | HIF-1? mediates tumor hypoxia to confer a perpetual mesenchymal phenotype for malignant progression | Although tumor progression involves genetic and epigenetic alterations to normal cellular biology, the underlying mechanisms of these changes remain obscure. Numerous studies have shown that hypoxia-inducible factor 1? (HIF-1?) is overexpressed in many human cancers and up-regulates a host of hypoxi... | ||
| 2 |
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Couldwell, William T. | Management of cysticercosis cerebri | Infestation of the central nervous system (CNS) with the parasitic larval form of the cestode Taenia solium, Cysticercosis Cerebri represents an endemic problem in much of the underdeveloped world. In such areas, up to 4% of the population maybe affected by neurocysticercosis, and it accounts for u... | Taenia solium; Cysticercosis Cerebri; Parenchymal cyst; Basilar cisternal cyst; Intraventricular cyst | 1989 |
| 3 |
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Couldwell, William T. | Pituitary gland metastasis from adenocarcinoma of the prostate | A case of prostatic carcinoma metastasis to the pituitary gland is reported. The presentation and rarity of such a lesion is addressed. The literature review yielded only isolated case reports of symptomatic brain metastases unassociated with bone disease from adenocarcinoma of the prostate. The man... | Prostate; Pituitary gland; Adenocarcinoma; Metastasis; Transsphenoidal surgery | 1989 |
| 4 |
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Kestle, John R. W. | Intervertebral disc embolization resulting in spinal cord infarction | A case of spinal cord infarction resulting from embolization of fibrocartilaginous intervertebral disc material is presented. Cases from the literature are reviewed and the theories of pathogenesis are discussed. In all reported cases the diagnosis was not made until postmortem examination. | Spinal cord infarction; Nucleus pulposus; Intervertebral disc; Embolization | 1989 |
| 5 |
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Couldwell, William T. | Utilization of unilateral and bilateral stereotactically placed adrenomedullary-striatal autografts in Parkinsonian humans: rationale, techniques, and observations | A limited clinical pilot study involving an amalgam of specialized disciplines including neurology, neuropharmacology, neuropsychology, neurosurgery, neuroanesthesia, neuroradiology, surgical pathology, neuropathology, and urological surgery was organized to clarify issues related to patient selecti... | Adrenal medullary graft; Autograft; Brain graft; Neural transplantation; Parkinsonism; Stereotaxy | 1990 |
| 6 |
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Couldwell, William T. | Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C system | The protein kinase-C (PKC) second messenger system contributes to regulation of cell growth and differentiation. This study was undertaken to examine the effects of modulators of the PKC enzyme system on the state of differentiation and proliferation rates of human gliomas in vitro. The administrat... | Protein kinase C; Phorbol ester; Cell proliferation; Tumor cell growth; Astrocyte; Glioma; Immunohistochemistry | 1990 |
| 7 |
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Couldwell, William T. | Immunology and immunotherapy of intrinsic glial tumors | Immunological aspects of glial neoplasms have been actively investigated for the past several years with particular focus on academic, diagnostic, and therapeutic objectives. As more knowledge is acquired about the cellular events relating to tumor behavior the more it appears that the immune system... | Immunology; Glial tumors | 1990 |
| 8 |
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Couldwell, William T. | Initial experience related to the use of the Cosman-Roberts-Wells stereotactic instrument | Initial experience with a new arc-radius design of stereotactic frame that interfaced with the existing components of the Brown-Roberts-Wells instrument is reported. Over a 6-month period, 32 procedures were performed on 23 males and nine female patients (mean age 32 years); these included 27 ster... | Image-directed stereotaxis; Stereotactic instrument; Cosman-Roberts-Wells stereotaxy | 1990 |
| 9 |
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Kestle, John R. W. | Propionibacterium encephalitis [Letter to the editor] | To THE EDITOR: We read with interest the article by Camarata, et al., reporting two cases of dorsal midbrain encephalitis (Camarata PJ, McGeachie RE, Haines S J: Dorsal midbrain encephalitis caused by Propionibacterium aches. Report of two cases. J Neurosurg 72." 654-659, April, 1990). There are... | 1990 | |
| 10 |
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Jaeckle, Kurt A.; Digre, Kathleen B.; Jones, Christopher R.; Bailey, Peter L. | Central neurogenic hyperventilation: pharmacologic intervention with morphine sulfate and correlative analysis of respiratory, sleep, and ocular motor dysfunction. | Central neurogenic hyperventilation (CNH), for which there is no effective therapy, can eventually result in respiratory fatigue and death. This report describes a patient with CNH due to a brainstem anaplastic astrocytoma who also exhibited disturbances of sleep and ocular motor function. The CNH r... | Central Neurogenic H yperventilation; Ocular Motor Dysfunction | 1990-11 |
| 11 |
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Couldwell, William T. | Strategies for the management of nonsecreting pituitary adenomas | The two objectives of treating pituitary tumors are: (1) relief of signs and symptoms attributable to mass effect, and (2) correction of hypo - or hypersecretion of adenohypophyseal hormones.7 When nonsecreting tumors are specifically considered, correction of endocrine abnormalities may be of les... | Pituitary adenomas; Transsphenoidal surgery | 1991 |
| 12 |
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Couldwell, William T. | Definition of the role of contemporary surgical management in cisternal and parenchymatous cysticercosis cerebri | With increasing immigration from endemic regions, the incidence of neurocysticercosis in North America is rising. This retrospective study was undertaken to examine the role of surgery in those cases presenting with large cystic parenchymal and cisternal lesions in the current era of anthelminthic a... | Brain cyst; Computed tomography; Neurocysticercosis; Magnetic resonance imaging; Praziquantel; Stereotaxis | 1991 |
| 13 |
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Couldwell, William T. | Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro | Direct measurement of protein kinase C (PKC) activity in vitro revealed a significant increase in the activity of the enzyme in all human malignant glioma lines examined and the rat C6 tumor in comparison with control nonneoplastic astrocyte and mixed glial cultures. The total and particulate PKC ac... | Brain neoplasms; Flow cytometry; Glioma; Phorbol ester; Protein kinase C | 1991 |
| 14 |
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Kestle, John R. W. | Comparison between magnetic resonance imaging and computed tomography for stereotactic coordinate determination | The spatial accuracy of magnetic resonance imaging (MRI) has not been established for stereotactic surgery. Magnetic susceptibility artifacts may lead to anatomical distortion and inaccurate stereotactic MRI coordinates, especially when targets are in regions of the brain out of the center of the ma... | Computed tomography; Stereotactic coordinates; Stereotactic surgery | 1992 |
| 15 |
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Couldwell, William T. | Protein kinase C activity correlates with the growth rate of malignant gliomas: Part II. Effects of glioma mitogens and modulators of protein kinase C | THE PROLIFERATION RATES of gliomas may be modulated by the protein kinase C (PKC) signal transduction system. The present study was undertaken to further examine the role of PKC system in growth regulation of gliomas in vitro by measurement of PKC activity over various phases of tumor growth and by ... | Protein kinase C; Brain neoplasms; Growth factor; Glioma; Phorbol ester | 1992 |
| 16 |
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Couldwell, William T. | Malignant glioma-derived soluble factors regulate proliferation of normal adult human astrocytes | Malignant gliomas are characteristically surrounded by marked gliosis. To assess whether glioma-derived products contribute to the proliferation of astrocytes, a feature of the gliosis response, we evaluated the influence of culture supernatants from malignant human glioma lines and tumor cyst fluid... | Astrocyte; Glioma; Gliosis; Proliferation; Soluble factors | 1992 |
| 17 |
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Digre, Kathleen B.; Skuster, Denise Z. | Neurologic conditions presenting as psychiatric disorders. | Understanding underlying neuroanatomic function helps physicians to localize defects and search for treatable neurologic conditions. Neurologic conditions such as Huntington's chorea, Wilson's disease, Gille de la Tourette syndrome, brain tumors, encephalitis and meningitis, neurodegenerative condit... | Psychiatric Diagnosis; Neurologic Disease | 1992-06-15 |
| 18 |
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Couldwell, William T. | Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifen | PREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C (PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro. Tamoxifen inhibits PKC in a minority of malignant gliomas within the micromolar concentration range in vitro, a property distinct from... | Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Chemotherapy; Glioma | 1993 |
| 19 |
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Couldwell, William T. | Protein kinase C inhibitors suppress cell growth in established and low-passage glioma cell lines. a comparison between staurosporine and tamoxifen | WE HAVE PREVIOUSLY demonstrated that the proliferation of established human glioma cell lines correlated with protein kinase C (PKC) activity and that a relatively selective PKC inhibitor, staurosporine, inhibits glioma cell proliferation. The purpose of this study was to determine whether low-passa... | Staurosporin; Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Glioma cell lines | 1993 |
| 20 |
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Couldwell, William T. | Penetrating craniocerebral injury resultant from gunshot wounds: gang-related injury in children and adolescents | WE PROSPECTIVELY AND retrospectively reviewed a series of 780 patients who presented to the University of Southern California/Los Angeles County Medical Center with a diagnosis of gunshot wound to the brain during an 8-year period. Of these, 105 were children ranging in age from 6 months to 17 yea... | Craniocerebral injury; Los Angeles County General Hospital; University of Southern California School of Medicine | 1993 |
| 21 |
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Couldwell, William T. | Cosmetic mastoidectomy for the combined supra/infratentorial transtemporal approach | The authors describe a cosmetic mastoidectomy technique for use when performing a combined supra/ infratentorial craniotomy and transtemporal exposure. The technique involves a single temporal suboccipital bone flap and cosmetic mastoidectomy, removing the outer table of bone for later replacement... | Surgical approach; Supratentorial approach; Infratentorial approach; Petroclival meningiomas | 1993 |
| 22 |
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Dailey, Andrew T. | Paragangliomas of the sellar region: report of two cases | TWO CASES OF paraganglioma arising from the parasellar region are presented. Both occurred in middle-aged women who sought treatment of headaches but who had no endocrinological dysfunction; one case was associated with ophthalmoplegia from cavernous sinus involvement. Diagnosis in both cases was ... | Paragangliomas; Sellar region; Parasellar region; Chemodectoma; Pituitary tumor | 1993 |
| 23 |
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Dailey, Andrew T. | Resolution of an actinomycotic abscess with nonsurgical treatment: case report | A CASE OF actinomycotic brain abscess is presented. Conservative treatment by prolonged administration of antibiotics after needle biopsy showed complete resolution of the abscess. Previously reported cases suggest that definitive treatment requires excision or open surgical drainage of the abscess... | Actinomycotic abscess; Brain abscess; Actinomyces israelii; Nonsurgical treatment | 1993 |
| 24 |
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Schmidt, Meic H. | Role of photodynamic therapy in posterior fossa brain tumors: a preclinical study in a canine glioma model | Photodynamic therapy was studied in dogs with and without posterior fossa glioblastomas. This mode of therapy consisted of intravenous administration of Photofrin-II at doses ranging from 0.75 to 4 mg/kg 24 hours prior to laser light irradiation in the posterior fossa. Tissue levels of Photofrin-l... | Brain neoplasm; Posterior fossa; Photodynamic therapy; Glioblastomas; Dog; Photofrin-II; Canine glioma model | 1993 |
| 25 |
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Couldwell, William T. | Life-threatening reactions to propofol | To the Editor: Propofol (2,6-diisopropyl phenol; Diprivan; Stuart Pharmaceuticals, Wilmington, DE) has been advocated as a titratable continuous infusion anesthetic agent associated with fast and smooth recovery (2, 7). The anesthetic properties of a smooth induction, short half-life, and rapid eme... | Propofol; Diprivan | 1993 |