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1 Couldwell, William T.Intracranial hypotension in the setting of concurrent perineural cyst rupture and subarachnoid hemorrhageAlthough most patients with intracranial hypotension typically present with headaches, the rest of the clinical spectrum is characteristically non-specific and often quite variable. In a patient with concurrent pathologies that can produce a similar clinical picture, a high index of suspicion must b...2013-01-01
2 Couldwell, William T.Thrombosed basilar apex aneurysm presenting as a third ventricular mass and hydrocephalusAneurysms presenting as third ventricular masses are uncommon; most are giant aneurysms arising from the basilar apex. We present a case of a thrombosed basilar apex aneurysm presenting as a third ventricular mass and hydrocephalus in a 55-year-old man. The case is unique in the literature as the an...Basilar apex aneurysm; Ventricular mass; Third ventriculostomy2005
3 Couldwell, William T.Petroclival meningiomas: surgical experience in 109 casesThe surgical removal of petroclival meningiomas has historically been associated with a high incidence of morbidity and mortality. The 109 consecutive patients included in the present retrospective study represent a combined series of tumors operated on by the four authors during a period from 1980 ...Petroclival meningiomas; Clivus; Brain neoplasm; Petrous bone; Posterior fossa; Skull base tumor1996
4 Couldwell, William T.Pituitary gland metastasis from adenocarcinoma of the prostateA case of prostatic carcinoma metastasis to the pituitary gland is reported. The presentation and rarity of such a lesion is addressed. The literature review yielded only isolated case reports of symptomatic brain metastases unassociated with bone disease from adenocarcinoma of the prostate. The man...Prostate; Pituitary gland; Adenocarcinoma; Metastasis; Transsphenoidal surgery1989
5 Couldwell, William T.Hearing restoration after resection of an intracanalicular vestibular schwannoma: a role for emergency surgery?Patients with vestibular schwannomas (VSs) most commonly present with sensorineural hearing loss, which is often insidious or gradual. Up to 26% of patients may present with sudden hearing loss, however, which poses an important surgical challenge. Sudden hearing loss has been attributed to spasm or...Vestibular schwannoma; Hearing preservation2002
6 Couldwell, William T.Far Lateral Transcondylar Approach for Resection of Neurenteric Cysts of the Cervicomedullary Junction (Far-lateral transcondylar approach: surgical technique and its application in neurenteric cysts of the cervicomedullary junction. Report of two cases.)Neurenteric cysts are rare benign lesions of the central nervous system that are lined by endodermal cell-derived epithelium. Although they occur mostly in the spine, they can occur intracranially, most often in the posterior fossa. Neurenteric cysts that are located in the anterior cervicomedullary...Cervical Vertebrae; Medulla Oblongata; Neural Tube Defects; Neurosurgical Procedure2005-08-15
7 Dailey, Andrew T.; Brodke, Darrel S.Dynamic cervical plates: biomechanical evaluation of load sharing and stiffnessStudy Design. An in vitro biomechanical study using a simulated cervical corpectomy model to compare the load-sharing properties and stiffnesses of two static and two dynamic cervical plates. Objectives. To evaluate the load-sharing properties of the instrumentation with a full-length graft and...In vitro biomechanical study; Cervical corpectomy; Cervical plates2001
8 Couldwell, William T.Diagnosis and management of Cushing diseaseThe management of a case involving Cushing disease, defined as excess secretion of adrenocorticotropic hormone (ACTH) from a pituitary adenoma, remains one of the most vexing problems facing the pituitary surgeon. The systemic consequences of this endocrinopathy are profound morbidity and premature...2007-01-01
9 Kestle, John R. W.Sporadic osteochondroma of the cervical spineOsteochondroma is the most common benign tumor of bone, but axial skeleton involvement is uncommon and usually indicates a hereditary cause such as osteochondromatosis (hereditary multiple exostosis). 1 Approximately 7% of hereditary osteochondromas occur along the vertebral column, which is double...2006
10 Schmidt, Meic H.Thoracoscopic spine surgery for decompression and stabilization of the anterolateral thoracolumbar spineThe anterior thoracolumbar spine can be exposed via a variety of approaches. Historically, open anterolateral or posterolateral approaches have been used to gain access to the anterior thoracolumbar spinal column. Although the exposure is excellent, open approaches are associated with significant pa...Endoscopic spinal surgery; Thoracic spine; Lumbar spine; Thoracoscopic spinal instrumentation2005
11 Couldwell, William T.Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic applicationProtein kinase C (PKC) is an enzyme involved in the regulation of cellular growth, proliferation, and differentiation in a number of tissues including the anterior pituitary, in which it is also believed to play a role in hormone secretion. Protein kinase C activity and expression have been found to...Apoptosis; Hypericin; Pituitary adenoma; Protein kinase C1996
12 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 9: fusion in patients with stenosis and spondylolisthesisGuidelines. The performance of a lumbar PLF is recommended for patients with lumbar stenosis and associated degenerative spondylolisthesis who require decompression. There is insufficient evidence to recommend a treatment guideline. Options. Pedicle screw fixation as an adjunct to lumbar PLF should ...Fusion; Lumbar spine; Degenerative disease; Lumbar fusion2005
13 Kestle, John R. W.Effect of single-application topical ophthalmic anesthesia in patients with trigeminal neuralgia: a randomized double-blind placebo-controlled trialTo evaluate the reported benefit of ipsilateral single-application ophthalmic anesthetic eyedrops in patients with typical trigeminal neuralgia, a randomized double-blind placebo-controlled trial was performed. Fortyseven patients were randomly assigned to receive two drops of either proparacaine (...Randomized trial; Ophthalmic anesthesia1994
14 Couldwell, William T.; Schloesser, Peter E.Hemorrhage from moyamoya-like vessels associated with a cerebral arteriovenous malformationThe authors describe a case of subarachnoid hemorrhage from moyamoya-like vessels associated with an arteriovenous malformation (AVM) in a 44-year-old Hispanic man who presented with severe headache. The AVM was located in the left parietal lobe and the ipsilateral middle cerebral artery was occlude...Moyamoya-like vessels; Arteriovenous malformation; Ischemia MeSH: Arteriovenous malformations2004
15 Couldwell, William T.Immunology and immunotherapy of intrinsic glial tumorsImmunological aspects of glial neoplasms have been actively investigated for the past several years with particular focus on academic, diagnostic, and therapeutic objectives. As more knowledge is acquired about the cellular events relating to tumor behavior the more it appears that the immune system...Immunology; Glial tumors1990
16 Couldwell, William T.; Orlandi, Richard R.; Jensen, Randy L.Endoscopic-assisted craniofacial resection of esthesioneuroblastoma: minimizing facial incisionsThe surgical management of esthesioneuroblastomas has traditionally been craniofacial resection, which combines a bifrontal craniotomy with a transfacial approach. The latter usually involves a disfiguring facial incision, mid-facial degloving, lateral rhinotomy, and/or extensive facial osteotomies...Esthesioneuroblastoma; Craniofacial resection; Endoscope; Craniofacial surgery; Minimally invasive2003
17 Digre, Kathleen B.; Mamalis, Nick; White, George L. Jr.Congenital anomalies of the optic nerve in one family.We present three cases of congenital optic disc anomalies in one family who underwent an extensive diagnostic workup to exclude any intracranial pathology. One patient had elevated optic nerve heads and was hospitalized for multiple diagnostic tests including a lumbar puncture and magnetic resonance...Optic Nerve; Congenital Anomalies1992-04-24
18 Couldwell, William T.Practicing neurosurgery in the United StatesCompared with other developed countries, the U.S. spends a high percentage of its gross domestic product on healthcare: 16 percent in 2005, up from 15 percent in 2004. This is far and away the greatest percentage of GDP spent on healthcare of any nation for which such data is collected. However,...2008-01-01
19 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 11: interbody techniques for lumbar fusionStandards. There is insufficient evidence to recommend a treatment standard. Guidelines. In the context of a single-level stand-alone ALIF or ALIF with posterior instrumentation, the addition of a PLF is not recommended as it increases operating room time and blood loss without influencing the like...Fusion; Lumbar spine; Degenerative disease; Lumbar fusion; Interbody techniques2005
20 Couldwell, William T.Radiographic features of tumefactive giant cavernous angiomasGiant cavernous angiomas (GCAs) are very rare, and imaging features of GCAs can be very different from those of typical cavernous angiomas (CAs), making them a diagnostic challenge. The purpose of the study was to evaluate the radiographic features of GCAs, with an emphasis on the differentiating fe...Cavernous angiomas; Cavernous malformations; Tumefactive2008
21 Couldwell, William T.Clinical and radiographic response in a minority of patients with recurrent malignant gliomas treated with high-dose tamoxifenPREVIOUS WORK HAS demonstrated the importance of the Protein Kinase C (PKC) signal transduction system in regulating the growth rate of malignant gliomas in vitro. Tamoxifen inhibits PKC in a minority of malignant gliomas within the micromolar concentration range in vitro, a property distinct from...Tamoxifen; Protein kinase C; Glioma; Brain neoplasm; Chemotherapy; Glioma1993
22 Dailey, Andrew T.Guidelines for the performance of fusion procedures for degenerative disease of the lumbar spine. Part 5: correlation between radiographic and functional outcomeStandards. There is insufficient evidence to recommend a treatment standard. Guidelines. There is insufficient evidence to recommend a treatment guideline. Options. It is recommended that when performing lumbar arthrodesis for degenerative lumbar disease, strategies to achieve successful radiogr...Lumbar fusion; Lumbar spine; Degenerative disease; Practice guidelines; Functional outcome; Radiographic outcome2005
23 Kestle, John R. W.Late rapid deterioration after endoscopic third ventriculostomy: additional cases and review of the literatureObject. Late rapid deterioration after endoscopic third ventriculostomy (ETV) is a rare complication. The authors previously reported three deaths from three centers. Three other deaths and a patient who experienced rapid deterioration have also been reported. Following the death at the University ...Endoscopic third ventriculostomy; ETV; Pediatric neurosurgery; Adverse outcome2006
24 Schmidt, Meic H.Syndrome of inappropriate secretion of antidiuretic hormone and hyponatremia after spinal surgeryHyponatremia caused by an inappropriately high level of antidiuretic hormone secretion after spinal surgery is an uncommon and self-limiting phenomenon that resolves within 2 or 3 weeks. During the early postoperative period, the patient's urine output and serum level of sodium should be monitored ...Syndrome of inappropriate antidiuretic hormone secretion; SIADH; Hyponatremia; Spinal surger2004
25 Couldwell, William T.; Nelson, Don HarryNelson syndrome: historical perspectives and current conceptsThe appearance of an adrenocorticotropic hormone (ACTH)-producing tumor after bilateral adrenalectomy for Cushing disease was first described by Nelson in 1958. The syndrome that now bears his name was characterized by hyperpigmentation, a sellar mass, and increased plasma ACTH levels. The treatment...2007-01-01
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