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1 Fgf10 is required for specification of non-sensory regions of the cochlear epitheliumThe vertebrate inner ear is a morphologically complex sensory organ comprised of two compartments, the dorsal vestibular apparatus and the ventral cochlear duct, required for motion and sound detection, respectively. Fgf10, in addition to Fgf3, is necessary for the earliest stage of otic placode ind...2014-01-01
2 Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: A report from the Childrens Oncology GroupBackground: The genetics involved in Ewing sarcoma susceptibility and prognosis are poorly understood. EWS/FLI and related EWS/ETS chimeras upregulate numerous gene targets via promoter-based GGAA-microsatellite response elements. These microsatellites are highly polymorphic in humans, and prelimina...2014-01-01
3 Secret of life module: on the brink, four profiles in groundbreaking scienceThis is a 15 minutes, 12 seconds segment of the WGBH series, Secret of life. Profiles include Dennis Slamon of UCLA and his work on the oncagenes and the creation of excess receptors that play a significant role in breast cancer; Patricia Steeg of the National Cancer Institute (NCI) and her work on...Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Cancer - Research; Capecchi, Mario R.; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis; Gene expression; Gene regulation
4 KSL News clip of Mario Capecchi receiving the National Medal of Science for 1991This 1 minute, 44 seconds news clip from Salt Lake City's KSLTV, Channel 5 shows Mario Capecchi receiving the National Medal of Science for 1991 from President George W. Bush at the June 13, 2002 awards ceremony. The medal was presented for Capecchi's work in genetics and his development of the pro...Transgenic mice; Gene targeting; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news1992-06
5 National Medals of Science and Technology Awards (2001) Ceremony and Banquet, held June 13, 2002This 51 minutes, 5 seconds video is divided into two parts: the first part is a film introducing the award winners and their achievements; the second is the presentation of the actual awards by George W. Bush, President of the United States. Medal winners were: Mario R. Capecchi for his pioneering...Molecular genetics; Gene targeting; Transgenic mice; Gene expression; Genetic engineering; Capecchi, Mario R.; Science - Awards - United States; Awards presentations2002
6 Creating mice with targeted disruptions in protooncogenes and homeobox genes, NIH Director's Lecture given May 21, 1992This is an audio transcript of a 1 hour, 2 minutes and 12 seconds lecture given at the National Institutes of Health by Mario Capecchi on 1992/05/21. Beginning with a short summary of the mechanics of gene transfer and the ability to create germline chimera with mutations that become hereditary wit...Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Mutagenesis; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype1992
7 AAMC Award for Distinguished Research presentation for 1998This is a 3 minutes, 51 seconds video of the presentation of the American Association of Medical Colleges' Award for Distinguished Research to Mario Capecchi and Oliver Smithies for their independent work as pioneers in gene targeting.Transgenic mice; Gene targeting; Genetic engineering; Mutagenesis; Capecchi, Mario R.; Science - Awards - United States; Smithies, Oliver; Awards presentations1998
8 KUTV news featurette on cloning, molecular genetics, and disease aired November 9, 1997This 3 minutes, 1 second video clip from Salt Lake City's KUTV, Channel 2 features a short interview with Mario Capecchi concerning cloning and its use in molecular genetics and the study of human diseases.Gene targeting; Genetic engineering; Molecular genetics; Cancer Research; Capecchi, Mario R.; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis; Television feature stories1997-11-09
9 Role of Hox genes in mediating the mammalian body planThis is a 1 hour, 5 minutes, 28 seconds video of a lecture given by Mario Capecchi on the genetic analysis of the Hox complex, or Hox cluster and their role in embryogenesis. Using examples such as the development of the hindbrain (rhombencephalon), facial nerves, and hands Capecchi outlines the re...Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype
10 Franklin Institute award dinner and ceremony held May 1, 1997This is a 1 hour, 42 minutes, 53 seconds video of the 1997 Franklin Institute Awards Banquet and Ceremony. The awards included a summary of each winner's achievements, the presentation of the award, and an acceptance speech. The award winners included Ralph L. Brinster, the Bower Award and Prize f...Transgenic mice; Gene targeting; Genetic engineering; Molecular genetics; Mutagenesis; Homeobox genes; Histology - Pathological; Gene expression; Gene regulation; Genotype; Phenotype1997
11 Albert Lasker Awards Ceremony, 2001This is the 1 hour, 45 minutes, and 41 seconds video of the Lasker Awards Ceremony and Banquet held in September, 2001. The Albert Lasker Award for Basic Medical Research was given to Mario R. Capecchi, Oliver Smithies, and Martin Evans for their work in genetic research. Martin Evans discovered h...Capecchi, Mario R.; Gene targeting; Embryonic stem cells; Transgenic mice; Genetic engineering; Science - Awards - United States; Smithies, Oliver; Evans, Martin J.; Awards presentations2001
12 Local television news clips for June 14, 1994 featuring Mario CapecchiThis is a compilation of news clips from Salt Lake City's four major commercial television stations (Channels 2, 4, 5, and 13) lasting a total of 2 minutes, 59 seconds. The topic is Capecchi's winning of the General Motors Corporation's Alfred P. Sloan Jr. Prize for Outstanding Basic Science Contrib...Transgenic mice; Gene targeting; Cancer - Research - Awards; Capecchi, Mario R.; Science - Awards - United States; Television broadcasting of news1994-06-14
13 Spinal muscular atrophy in DrosophilaSpinal Muscular Atrophy (SMA) is the most commonly inherited form of motor neuronal disease in humans and a leading cause of infant mortality. SMA is characterized by a loss of motor neurons which lead to muscle degeneration, paralysis, and eventual death by respiratory failure. More than ninety-f...Trapeze Interactive Poster2010-03-15
14 Copy number variation in a follow-up of adults with ASD: a behavioral phenotype-genotype studyAutistic Spectrum Disorders (ASD) are a set of complex, early-onset neurodevelopmental disorders. Recent studies have revealed a complex genetic landscape for ASD, with many potential genes involved. Little is known about the long-term outcome of individuals with ASD who were diagnosed in childhoo...Autistic spectrum disorders; Copy number variation; Genotyping; Trapeze Interactive Poster2010-03-15
15 Genetics in Utah : NPR talk of the nation, science Friday for May 15, 1998This is a 1 hour, 9 seconds audio transcript of National Public Radio's Science Friday that was taped at Westminster College of Salt Lake on 1998/05/15. The host, Ira Flatow, leads a panel composed of University of Utah scientists and researchers, Jeffrey Bodkin, Mario Capecchi, Ray Gesteland, Mark...Genetic engineering; Molecular genetics; Capecchi, Mario R.; Homeobox genes; Science - Moral and ethical aspects; Human chromosome abnormalities - Diagnosis1998
16 Expression levels influence ribosomal frameshifting at the tandem rare arginine codons AGG_AGG and AGA_AGA in Escherichia coliABSTRACT: The rare codons AGG and AGA comprise 2% and 4%, respectively, of the arginine codons of Escherichia coli K-12, and their cognate tRNAs are sparse. At tandem occurrences of either rare codon, the paucity of cognate aminoacyl tRNAs for the second codon of the pair facilitates peptidyl-tRNA...Gene expression; Frameshifting; E. coli; Arginine codons2005
17 Crystallization of the MS2 translational repressor alone and complexed to bromouridineThe coat protein from the MS2 bacteriophage plays a dual role by encapsidating viral RNA and also by binding RNA as a translational repressor. In order to study the isolated dimer in a conformation not influenced by capsid interactions, a mutant molecule was crystallized that is defective in capsid ...Crystallization; RNA Bacteriophage; RNA Hairpin; Translational Repressor1995
18 Housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland.Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in purine catabolism occurring in most cell types. However, this housekeeping gene is expressed at very high levels in a number of mammalian tissues including the lactating mammary epithelium, suggesting additional roles for XOR in these tiss...Body Weight; Cell Differentiation; Cell Membrane; Epithelium2002-12-15
19 Characterization of lysozyme messenger and lysozyme synthesized in vitroIn vitro systems for protein systhesis have been in wide use for about 10 years. In most of the early work protein synthesis was measured by following the incorporation of radioactive amino acids into acid precipitable material. This test cannot distinguish between the synthesis of complete, activ...Lysozyme Messenger; Lysozyme Synthesized; Protein Synthesis1969
20 Initiation of E. coli proteins.Recent experiments and theoretical arguments suggest that formylmethionyl sRNA is employed as an initiator of protein synthesis. Studies also indicated that other phage proteins synthesized in the in vitro system were initiated with formylmethionine. These observations provided a basis for believin...Alanine; Chromatography, Paper; Dipeptides1966-06
21 Targeted mutations in hoxa-9 and hoxb-9 reveal synergistic interactions.Mice were generated with a targeted disruption of the homeobox-containing gene hoxb-9. Mice homozygous for this mutation show defects in the development of the first and second ribs. In most cases the first and second ribs are fused near the point at which the first and second pairs of ribs normally...Embryonic and Fetal Development; In Situ Hybridization; Mice, Knockout1997-01-15
22 Hox11 paralogous genes are essential for metanephric kidney inductionThe mammalian Hox complex is divided into four linkage groups containing 13 sets of paralogous genes. These paralogous genes have retained functional redundancy during evolution. For this reason, loss of only one or two Hox genes within a paralogous group often results in incompletely penetrant phen...Metanephric; Six2; Wt12002-06-01
23 Translation of Rl7 RNA fragmentsExamination of the events during infection of cells by RNA phages reveals phemonomena that are surprisingly complex for a virus that has only enough information to code for three to four proteins. The coat protein is synthesized at a rapid rate through most of the infectious cycle making it the pre...Electrophoresis; RNA, Messenger; Peptide Biosynthesis; Kinetics1969
24 Lessons from angiotensin-converting enzyme-deficient mice.Mice which lack ACE have low systolic blood pressure, reduced male fertility and a renal abnormality characterized by medullary hypoplasia and the inability to concentrate urine. The diverse phenotypes caused by inactivation of a single gene emphasize the many functional roles of ACE and the renin-q...Blood Pressure; Cell Line;Fertility; Kidney; Testis1991-11-01
25 Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function.Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has...Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors2004-11-01
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