Honors Theses Open Access
 
Filters: Department: "Chemistry" Collection: "ir_htoa" Year Start: 2019
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1 Godfrey, RoseA porcine model for the development and testing of preoperative skin preparationsClinical preoperative skin preparations (PSPs) do not eradicate skin flora dwelling in the deepest dermal regions. Survivors constitute a persistent infection risk. In search of solutions, we created a porcine model intended for PSP developmental testing. This model employed microbiological techniqu...2022
2 Arnoholt, AlaynaAn analysis on the influence of anxiety in post error slowingAnxiety disorders are among the most common mental disorders and affect 15.7 million Americans each year (Lépine, 2002, p. 4). Anxiety is associated with reduced productivity, physical distress, and other diseases such as depression. Anxiety could also be influential in error response (Compton et a...2021
3 Galinat, ShelbyBipyrimidine solubility modeling for applications in NON-Aqueous redox flow batteriesEnergy storage research has undergone transformative changes in the past 50 years. The increasingly concerning threat of climate change has emphasized the need for energy storage technology to facilitate renewable energy incorporation into the grid. Without energy storage, the fluctuations of wind a...2022
4 Besic, ArnelCreation and characterization of organic mixed conductorsOrganic mixed ionic electronic conductors (OMIECs) are conjugated polymers that conduct both ions and electrons. These materials are promising for applications in healthcare and energy technologies, including biosensors and batteries. An obstacle for using these materials in next-generation technolo...2024
5 Munn, JacksonDetermining microbial community composition and methane flux or red butte canyon sediment over timeMethane is a potent greenhouse gas that is released from the soil into the atmosphere, which contributes heavily to global warming. One potential way of reducing the amount of methane in the air is through studying methane consuming bacteria (methanotrophs) and how they interact with other microbes ...2022
6 Lutz, KevinDiscovery of platinum (II) cocrystals with highly fluorinated cyanocarbonsThis thesis investigates new platinum(II) complex cocrystals with highly fluorinated cyanoaromatics. While π stacking compounds of polycyclic aromatic hydrocarbons and cyanoaromatics have been reported, interactions with transition metal complexes have yet to be explored. Crystal structures for (pp...2023
7 Ballif, MicahDrugs and Pregnancy: Clinical Management with a Cystic Fibrosis FocusDespite the large number of women who become pregnant and use a medication during their pregnancy, there is very little information about the safety of the majority of medications. Most drugs approved by the FDA have undetermined teratogenic risk, but their use is prevalent in the management of dise...2019
8 Spurlock, Ella K.Exploration of the 2-dimensional π-d conjugated coordination polymer Cu-benzenehexathoilCoordination polymers (CPs) are a type of atomically precise material that has long been an area of study for materials chemists. Recently, research has advanced with twodimensional conjugated CPs as detailed synthetic schemes are developed to create highly atomically ordered, large-area sheets. The...2022
9 Coplan, Caitlin DeniseFabrication and Application of Aluminum NanostructuresPlasmonics, the phenomenon resulting from light interactions with nanoscale structures, is an active field for nanoscale manipulation of light. By varying the metal, size, and shape, plasmonic nanostructures can be tuned to interact with a broad spectral range of light. Commonly used plasmonic mater...2019
10 Narasipura, Eshan AmruthFull synthesis of enzymatically cleavable linker between 929-designed ankyrin repeat protein and 17-dimethlyamino geldanamycinTargeted cancer therapeutics are an important and promising field of cancer research due to their ability to reduce the off target effects produced in other therapies such as chemotherapy. Antibody Drug Conjugates (ADC) are one such therapeutic that specifically target cancer cells through antibody-...2021
11 Capener, JacobG Protein-Coupled resecptor kinase 2 mediated phosphorylation for The Activation of SmoothenedThe Hedgehog (Hh) pathway is a cell signaling pathway that is involved in embryonic development and adult tissue maintenance in vertebrates. Improper functioning of this pathway can lead to developmental disorders and several forms of cancer. Despite the pathway's biological importance, the transduc...2020
12 Jones, Kathryn K.Hybrid Enzyme-Bimetallic Nanoparticle System for Tandem Oxidation CatalysisMetallic nanoparticles are commonly used as catalysts in industrial and academic settings. Recent observations that bimetallic nanoparticles can have enhanced activity over their monometallic counterparts has increased the interest in their synthesis and application to new catalytic systems. Combini...2020
13 Owen, Cameron J.Infrared Multiple Photon Dissociation Spectroscopy and Guided Ion Beam Tandem Mass Spectrometry: Experimental and Theoretical investigations of Transition Metal and Lanthandie CationsEmployment of Free Electron Lasers (FELs) and a Guided Ion Beam Tandem Mass Spectrometer (GIBMS) has allowed for the spectroscopic and spectrometric investigations of a variety of ionic complexes, respectively. The data presented in Chapters 2 and 3 of this thesis were obtained using two FELs locate...2019
14 Hansen, MasonInterferon gamma inducible nampt and its role in resisting cancer cell growthThe tumor microenvironment (TME) is very complex and important due to its ability to influence the response of therapies on tumors. Immune cells infiltrate the TME and secrete inflammatory cytokines, such as interferon-gamma (IFNg), which help activate the immune system. This activation leads to an ...2023
15 Ray, Stella OliveThe learning assistant experience: documenting the perspectives of learning assistants at the University of UtahPeer-led collaborative learning models have been shown to improve student comprehension and engagement in undergraduate STEM courses [1]. Learning Assistant (LA) programs in particular, have been shown to transform introductory STEM courses and improve outcomes for students [1] [2]. While there has ...2021
16 Wang, Alisonmechanistic studies of the electrocatalytic reducation of Co2 to Co: a BPY-MN(CO)3coome model2023
17 Scholl, WallisNanomite-Decorated Nanoparticles as Surface-Enhanced Spectroscopy SubstratedSurface-enhanced spectroscopy substrates utilize the localized surface plasmon resonance of nanoparticles for optical, photocatalysis, and biological and chemical sensing applications. Plasmonic anisotropic nanoparticles with sharp tips focus the electromagnetic field of the localized surface plasmo...2020
18 Cowley, JacobOptimization of total synthesis of indolizidine alkaloids VIA nickel catalyzed (4 + 2) cyclization utilizing silyl and stannyl alkynesIn order to expand the versatility of the synthetic route to naturally occurring indolizidine alkaloids previously developed in the Louie Group, a path was developed using a bicyclic azetidinone to produce indolizidine alkaloids such as (+)-seco-antofine. However, due to the asymmetric nature of the...2021
19 Duffin, CalderSequence Activity Relaqtionships in a Radical Sam Peptide MaturaseRibosomally synthesized and post-translationally modified peptide Tte1186a and several point mutation variants are synthesized using solid phase peptide synthesis with FMOC amino acids. Substrate recognition and thioether linkage formation from the radical S-adenosyl methionine Tte1186 maturase is d...2020
20 Olsen, NicholasSimple Molecular Models for Chiral CrystallizationChiral molecules play an important role in many biological processes.1 Important chiral biomolecules include certain amino acids, sugars, DNA, RNA, and many proteins. Chiral molecules have enantiomers, mirror-image isomers that cannot be superimposed on each other. The classic analogy to enantiomers...2020
21 Reece, Eric J.Synthesis and Characterization of Proton Conducting Silica Nano-Particles for use in Polymer Electrolyte Membrane Fuel CellsOne of the fastest growing fields in scientific research is alternative energy. This has led to an investigation into the various aspects of fuel cells and their components due to their highly efficient energy conversion and low CO2 emissions. The efficiency of fuel cells is highly dependent on the ...2019
22 Cantrell, Rachel Lou-La VonneSynthesis of Antibiotic Scaffolds Inspired by the Tan 1057-D Biologically Active Natural Product Through the Utilization of Ullmann Copper(I) and Gold Cyclization ChemistryAs bacterial resistance to drugs continues to rise, the search for new antibiotics is of paramount importance. One key element to finding successful antibiotics is to uncover small molecules that act through novel mechanisms of action in order to decrease the risk of cross-resistance and provide ant...2020
23 Randolph, CharlotteSynthesis of VLC-Pufas relating to macular degenerative diseasesVery Long Chain Polyunsaturated Fatty Acids (VLC-PUFAs) are non-dietary fatty acids that are more than 24 carbons long and include more than one double bond. The specific compound we have focused on is 32:6 n-3: a 32-carbon molecule having 6 cis alkenes with the alkenes beginning at the omega 3 carb...2022
24 Aderibigbe, JustisTrends in the usage of bidentate phosphines as ligands in nickel catalysis of hydrogenation reactionsA critically important process in catalysis is the formation of an active catalyst from the combination of a metal precursor and a ligand, as the efficacy of this reaction governs the amount of active catalyst. This review is a compacted but comprehensive review of reactions catalyzed by nickel and ...2021
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