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CreatorTitleDescriptionSubjectDate
1 Narus, Scott P.Birth of identity: Understanding changes to birth certificates and their value for identity resolutionIntroduction Identity information is often used to link records within or among information systems in public health and clinical settings. The quality and stability of birth certificate identifiers impacts both the success of linkage efforts and the value of birth certificate registries for identit...2014-01-01
2 Huser, VojtechRunning decision support logic retrospectively to determine guideline adherence: a case study with diabetesWe describe the application of our previously developed analytical infrastructure called RetroGuide to conduct studies on retrospective data using a clinician friendly flowchart paradigm. Introduction Requiring additional clinician?s input in a new decision support system (DSS) is often a major imp...retroguide; time series analysis; retrospective observational study; diabetes; hypertension; clinical guidelines; knowledge representation; RetroGuide2007-05-14
3 Warner, Homer R.An Analysis of Granulocyte Kinetics in Blood and Bone MarrowBiomedical Informatics1964
4 Warner, Homer R.Quantitation of Backflow in Patients with Aortic Insufficiency Using an Indicator TechnicBiomedical Informatics1958
5 Warner, Homer R.Regulation of Cardiac Output Through Stroke VolumeBiomedical Informatics1960
6 Warner, Homer R.Effect of Heart Rate on Aortic Insufficiency as Measured by a Dye-Diluation TechniqueBiomedical Informatics1961
7 Warner, Homer R.Quantitation of Stroke Volume Changes in Man From the Central Pressure PulseBiomedical Informatics1954
8 Warner, Homer R.The Use of an Analog Computer for Analysis of Control Mechanisms in the CirculationBiomedical Informatics1959
9 Warner, Homer R.Medical Diagnosis Using a Digital Computer and Analog Computer Technics in Study of Control Mechanisms in the Circulatory SystemBiomedical Informatics1961
10 Warner, Homer R.The Use of an Analog Computer for Analysis of Physiological SystemsBiomedical Informatics1960
11 Warner, Homer R.Simulation as a Tool for Biological ResearchBiomedical Informatics1964
12 Warner, Homer R.A Study of the Mechanism of Pressure Wave Distortion by Arterial Walls Using an Electrical AnalogBiomedical Informatics1957
13 Warner, Homer R.The Central Arterial Pressure Pulse Contour as an Index to Left Ventricular Stroke Volume in ManBiomedical Informatics1953
14 Narus, Scott P.A domain analysis model for eIRB systems: addressing the weak link in clinical research informaticsInstitutional Review Boards (IRBs) are a critical component of clinical research and can become a significant bottleneck due to the dramatic increase, in both volume and complexity of clinical research. Despite the interest in developing clinical research informatics (CRI) systems and supporting dat...2014-01-01
15 Blumenthal, Donald K.; Underwood, Clayton J.Adaptation of the protein kinase filter paper assay to a 96-well microtiter format.The most widely used method for assaying protein kinase activities involves incorporation of radioactive phosphate into a protein or peptide substrate with subsequent binding or precipitaion of the radiolabeled substrate onto filter paper squares. We have adapted this assay for use with readily avai...Protein Kinase Activities; Filter Papers; Radioactive Phosphate1999-02-01
16 Blumenthal, Donald K.Identification of the substrate and pseudosubstrate binding sites of phosphorylase kinase gamma-subunit.Using site-directed mutagenesis, we proposed that an autoinhibitory domain(s) is located at the C-terminal region (301-386) of the phosphorylase kinase gamma-subunit (Huang, C.-Y.F., Yuan C.-J., Livanova, N.B., and Graves, D.J. (1993) Mol. Cell. Biochem. 127/128, 7-18). Removal of the putative inhib...Mutagenesis; Autoinhibitory Domain; Peptides1995-03-31
17 Blumenthal, Donald K.Effects of deletions in the central helix of calmodulin on enzyme activation and peptide binding.Using site-directed mutagenesis we have expressed in Escherichia coli three engineered calmodulins (CaM) containing deletions in the solvent-exposed region of the central helix. These are CaM delta 84, Glu-84 removed; CaM delta 83-84, Glu-83 and Glu-84 removed; and CaM delta 81-84, Ser-81 through Gl...Drug Effects; Genetics; Metabolism1989-05-15
18 Del Fiol, GuilhermeHeuristics in managing complex clinical decision tasks in experts decision makingBackground: Clinical decision support is a tool to help experts make optimal and efficient decisions. However, little is known about the high level of abstractions in the thinking process for the experts. Objective: The objective of the study is to understand how clinicians manage complexity while...2014-01-01
19 Del Fiol, GuilhermeClinical questions raised by providers in the care of older adults: a prospective observational studyObjective: To characterise clinical questions raised by providers in the care of complex older adults in order to guide the design of interventions that can help providers answer these questions. Materials and methods: To elicit clinical questions, we observed and audio recorded outpatient visits at...2014-01-01
20 Blumenthal, Donald K.Characterization of the calmodulin-binding and catalytic domains in skeletal muscle myosin light chain kinase.Limited proteolysis has been utilized to study the structural organization of rabbit skeletal muscle myosin light chain kinase. The enzyme (Mr approximately 89,000 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis) consists of an amino-terminal, protease-susceptible region of unidentified...Enzymology; Skeletal Muscle; Proteolysis, Peptide Fragments1995-09-15
21 Blumenthal, Donald K.Characterization of the regulatory domain of the gamma-subunit of phosphorylase kinase. The two noncontiguous calmodulin-binding subdomains are also autoinhibitory.Phosphorylase kinase is a multimeric protein kinase (alpha 4 beta 4 gamma 4 delta 4) whose enzymatic activity is conferred by its gamma-subunit. A library of 18 overlapping synthetic peptides spanning residues 277-386 of the gamma-subunit has been prepared to use in identifying important regulatory ...Metabolism; Phosphorylase Kinase1995-09-22
22 Blumenthal, Donald K.C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change.We present structural data on the RI alpha isoform of the cAMP-dependent protein kinase A that reveal, for the first time, a large scale conformational change within the RI alpha homodimer upon catalytic subunit binding. This result infers that the inhibition of catalytic subunit activity is not the...Protein Kinase; cAMP2004-04-30
23 Drews, Frank; Westenskow, Dwayne R.; Agutter, James A.; Strayer, David LeeDevelopment and evaluation of a anesthesia drug displayBACKGROUND: Usable real-time displays of intravenous anesthetic concentrations and effects could significantly enhance intraoperative clinical decision-making. Pharmacokinetic models are available to estimate past, present, and future drug effect-site concentrations, and pharmacodynamic models are a...Blood Pressure; Computer Graphics; Patient Simulation2002-03
24 Mitchell, Joyce A.Beyond relevance--characteristics of key papers for clinicians: an exploratory study in an academic settingObjective: The purpose of this study was to determine what factors beyond relevance influence a clinician's decision to choose to read one journal article over another in satisfying an information need. Design: Seventeen health care providers were interviewed and then surveyed regarding the characte...1996-01-01
25 Mitchell, Joyce A.A medical microcomputer database management systemThe Patient Data Handler (PDH) is a general purpose, interactive, relational database management system (DBMS) which was created to store and retrieve the patient records stemming from a research project centering upon the genetic causes and diagnosis of concomitant deafness and blindness [1, 5]. Th...1985-01-01
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