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1 Blumenthal, Donald K.C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change.We present structural data on the RI alpha isoform of the cAMP-dependent protein kinase A that reveal, for the first time, a large scale conformational change within the RI alpha homodimer upon catalytic subunit binding. This result infers that the inhibition of catalytic subunit activity is not the...Protein Kinase; cAMP2004-04-30
2 Huser, Vojtech; Del Fiol, Gulherme; Rocha, Roberto A.Use of XML Technology for E-resources Management within a Healthcare EnterpriseProvision of access to electronic resources to clinicians is becoming increasingly important. We have created a framework for librarians to manage access to e-resources at enterprise level rather than separately at individual hospital libraries. We present our initial project requirements, implement...Biomedical informatics; E-resources; Knowledge representation; Knowledge management; XML; XSLT; Intermountain Healthcare; Medical informatics2008-03-14
3 Drews, Frank; Westenskow, Dwayne R.; Agutter, James A.; Strayer, David LeeDevelopment and evaluation of a anesthesia drug displayBACKGROUND: Usable real-time displays of intravenous anesthetic concentrations and effects could significantly enhance intraoperative clinical decision-making. Pharmacokinetic models are available to estimate past, present, and future drug effect-site concentrations, and pharmacodynamic models are a...Blood Pressure; Computer Graphics; Patient Simulation2002-03
4 Mitchell, Joyce A.Beyond relevance--characteristics of key papers for clinicians: an exploratory study in an academic settingObjective: The purpose of this study was to determine what factors beyond relevance influence a clinician's decision to choose to read one journal article over another in satisfying an information need. Design: Seventeen health care providers were interviewed and then surveyed regarding the characte...1996-01-01
5 Mitchell, Joyce A.A medical microcomputer database management systemThe Patient Data Handler (PDH) is a general purpose, interactive, relational database management system (DBMS) which was created to store and retrieve the patient records stemming from a research project centering upon the genetic causes and diagnosis of concomitant deafness and blindness [1, 5]. Th...1985-01-01
6 Mitchell, Joyce A.Quality evaluation of controlled clinical information service trialsRandomized controlled clinical trials are increasingly accepted as tools of computer technology assessment and, therefore, quality evaluation of trials has great theoretical and practical significance. The purpose of this study was to assist the design of evaluation studies and synthesis of publishe...1993-01-01
7 Mitchell, Joyce A.A decision-support system for the analysis of clinical practice patternsSeveral studies documented substantial variation in medical practice patterns, but physicians often do not have adequate information on the cumulative clinical and financial effects of their decisions. The purpose of developing an expert system for the analysis of clinical practice patterns was to a...1994-01-01
8 Mitchell, Joyce A.Mendelian inheritance in man: diagnoses in the UMLSBecause they deal with many distinct but rare inheritance diseases, geneticists have difficulty translating from their codes to other biomedical coding schemes. The objective ofthis research was to investigate the potential uses and difficulties of using the UMLS Metathesaurus for genetic diagnoses ...1993-01-01
9 Mitchell, Joyce A.Construction of a medical informatics thesaurusMedical Informatics needs a specific terminology that reflects the multi-disciplinary nature of the field and can rapidly change as the discipline evolves. Using the four primary methods of thesaurus construction, a group at the University of Missouri- Columbia is developing a thesaurus that meets t...1994-01-01
10 Mitchell, Joyce A.The Missouri planning grant for the education and training of health sciences librariansThe planning grant at the School of Library and Informational Science (SLIS) at the University of Missouri has two aims: (a) developing a model curriculum for health sciences librarianship at the master's level and (b) developing materials that can be delivered by alternative instructional methods. ...1996-01-01
11 Mitchell, Joyce A.From phenotype to genotype: issues in navigating the available information resourcesObjectives-As part of an investigation of connecting health professionals and the lay public to both disease and genomic information, we assessed the availability and nature of the data from the Human Genome Project relating to human genetic diseases. Methods-We focused on a set of single gene disea...2003-01-01
12 Mitchell, Joyce A.Evidence-based retrieval in evidence-based medicineObjective: Clinical decisions based on a meta-analysis that is based on an ineffective retrieval strategy may have serious negative consequences for patients. The study objective was to investigate the extent to which meta-analyses report proof of their retrieval strategies' effectiveness. Methods: ...2004-01-01
13 Mitchell, Joyce A.Design and evaluation of a personal digital assistant-based alerting service for cliniciansPurpose: This study describes the system architecture and user acceptance of a suite of programs that deliver information about newly updated library resources to clinicians' personal digital assistants (PDAs). Description: Participants received headlines delivered to their PDAs alerting them to new...2004-01-01
14 Mitchell, Joyce A.Bioinformatics linkage of heterogeneous clinical and genomic information in support of personalized medicineObjectives: Biomedical Informatics as a whole faces a difficult epistemological task, since there is no foundation to explain the complexities of modeling clinical medicine and the many relationships between genotype, phenotype, and environment. This paper discusses current efforts to investigate su...2007-01-01
15 Mitchell, Joyce A.Fuzzy measures on the Gene Ontology for gene product similarityOne of the most important objects in bioinformatics is a gene product (protein or RNA). For many gene products, functional information is summarized in a set of Gene Ontology (GO) annotations. For these genes, it is reasonable to include similarity measures based on the terms found in the GO or othe...2006-01-01
16 Mitchell, Joyce A.Challenges and strategies of the Genetics Home ReferenceObjective: This paper focuses on the first two years of operation of Genetics Home Reference (GHR), a Web-based resource for the general public that helps to explain the health implications of findings from the Human Genome Project. Methods and Findings: Key challenges o...2006-01-01
17 Mitchell, Joyce A.Predicting phenotypic severity of uncertain gene variants in the RET Proto-OncogeneAlthough reported gene variants in the RET oncogene have been directly associated with multiple endocrine neoplasia type 2 and hereditary medullary thyroid carcinoma, other mutations are classified as variants of uncertain significance (VUS) until the associated clinical phenotype is made clear. Cur...2011-01-01
18 Mitchell, Joyce A.Integrating historical clinical and financial data for pharmacological researchBackground: Retrospective research requires longitudinal data, and repositories derived from electronic health records (EHR) can be sources of such data. With Health Information Technology for Economic and Clinical Health (HITECH) Act meaningful use provisions, many institutions are expected to adop...2011-01-01
19 Mitchell, Joyce A.Using information prescriptions to refer patients with metabolic conditions to the Genetics Home Reference websiteObjectives: The objectives of this study were to assess the reactions of adult patients and parents of children with metabolic conditions to receipt of an ‘‘information prescription'' (IP) to visit Genetics Home Reference (GHR), a National Institutes of Health/National Library of Medicine online...2011-01-01
20 Mitchell, Joyce A.50 Years of informatics research on decision support: what's nextObjectives: To reflect on the history, status, and future trends of decision support in health and biomedical informatics. To highlight the new challenges posed by the complexity and diversity of genomic and clinical domains. To examine the emerging paradigms for sup - porting cost-effective, person...2011-01-01
21 Mitchell, Joyce A.Personalized medicineWith the completion of the Human Genome Project in 2003, the world's attention has focused on converting this vast storehouse of information into innovative health care solutions. The ultimate promise, assuming we know everyone's genotype, is to ensure that every person has optimum health throughout...2007-01-01
22 Mitchell, Joyce A.International efforts in nanoinformatics research applied to nanomedicineBackground: Nanomedicine and nanoinformatics are novel disciplines facing substantial challenges. Since nanomedicine involves complex and massive data analysis and management, a new discipline named nanoinformatics is now emerging to provide the vision and the informatics methods and tools needed fo...2011-01-01
23 Mitchell, Joyce A.Nanoinformatics: a new area of research in nanomedicineAbstract: Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, wit...2012-01-01
24 Mitchell, Joyce A.Evaluating the informatics for integrating biology and the bedside system for clinical researchBackground: Selecting patient cohorts is a critical, iterative, and often time-consuming aspect of studies involving human subjects; informatics tools for helping streamline the process have been identified as important infrastructure components for enabling clinical and translational research. We d...2009-01-01
25 Mitchell, Joyce A.Retrieval from full-text medical literature: the dream & the realityWhile the retrieval of the full-text of a document might seem to end all the hassle of using traditional retrieval systems, the results of the MEDLINE/Full-Text Project indicate that retrieval from the current full-text databases of biomedical journal literature does not match the dream. During the ...1991-01-01
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