Honors Theses Open Access
 
Filters: Department: "Biomedical Engineering" Collection: "ir_htoa"
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1 Taggart, Maxwell M.A novel MRI-based screening method for assessing atrio-esophageal fistula risk following cardia ablationAtrio-esophageal fistulas affect 1 in 2000 patients who undergo cardiac ablation procedures with a mortality rate of 93%. Methods for detecting atrio-esophageal fistula formation that are objective and non-invasive could reduce the mortality associated with this disease. This study was performed ret...Magnetic resonance imaging; Cardia ablation; Trio-esophageal fistual2014-12
2 Gilbert, JohnA novel tool to capture neural activity across an entire brain using C-FOS as an indicatorImmunohistochemical staining for the expression of the immediate early gene c-Fos is a powerful tool to measure neuronal activation of neurons across an entire brain. The results of c-Fos immunostaining are often quantified by counting the number of immunolabeled cells in a region of interest (ROI) ...Brain - Localization of functions - Research; Brain - Physiology - Research; Brain mapping - Research; Memory - Research; Mice as laboratory animals - Research; Brain activity; Immunohistochemical staining2016-05
3 Loftus, Patrick D.Agonist binding of herg K+ channels inhibits epithelial cell extrusion but not apoptosis in MDCK monolayers; providing possibilities to cancer metastasis regulationMetastasis is commonly referred to as cancerous cell movement from an original site to one or more sites elsewhere in the body. When these moving cancerous cells are malignant, an individual's chance of survival is decreased. In order for epithelial cells to move they are detached from the epitheliu...Biomedical Engineering2012-01
4 Sharma, KapilAnalyzing the relationship between PDM2 and B-catenin proteins in human cancersTumorigenesis is promoted by the manipulation of several co-factors and pathways, in which PKM2 and P-catenin proteins play a significant role in a variety of cancers. New research states that these two hegemonic cancer proteins directly bind with each other and may provide a new angle for cance...Pyruvate kinase - Research; Tumorigensis - Research2016-04
5 Anjewierden, ScottAutomated kinematic analysis of pre-pluse inhibition in larval zebrafishAnimals differentially ignore or attend to sensory information depending on their immediate environment. A significant example of this phenomenon is audiomotorpre-pulse inhibition (PPI), in which the startle response to a loud noise is suppressed by a preceding stimulus of lower intensity. This a...Zebra danio - Development; Kinematics - Research; Kinematic parameters; Swim kinematics; Pre-pulse inhibition2014-12
6 Tarboton, PaisleyCharacterization of Apoptosis and Inhibitory Neurons in Cortical Organoids Generated from Human Induced Pluripotent Stem Cells.Modeling human brain diseases in a laboratory setting is critical to understanding the underlying pathology and developing new treatments for patients. Organoids are 3D tissue cultures that provide a promising way to model human brain development in vitro and have been used previously to gain novel ...2018
7 Sowards, SteffanComputational fluid dynamics modeling for Respiratory airflow patterns of python regiusThe phylogenetic distribution and mechanisms underpinning unidirectional pulmonary airflow, in which gases pass through a portion of the lung in an identical direction during both aspiration and expiration, are poorly understood. Until recently, it was thought this pattern of flow required unique fe...2018
8 Young, MichaelThe Contributions of Elastin to Ligament ViscoelastictyLigaments exhibit viscoelastic behavior in response to strain. This behavior protects joints from injury during loading. Collagen is the primary structural component of ligaments, but does not account fully for the viscoelastic behavior. Elastin is another structural protein in ligaments, and provid...2017
9 Adams, Samuel I.Correcting acoustic phase aberrations in focused ultrasound treatments for breast cancerBreast cancer is the most diagnosed cancer worldwide. Early-stage localized cancers are currently treated with surgical lumpectomy and radiation. Focused ultrasound is a disruptive technology that can replace conventional surgical and radiation therapies to provide noninvasive cancer treatment. This...2021
10 Gajiwala, SnehalDetermining the variability of depressive brain circuitry among healthy subjects for deep brain stimulationDeep Brain Stimulation (DBS) is being evaluated to treat Treatment-Resistant Depression, though it has shown mixed results. We believe that variability within the fiber tracts of the brain may account for these outcome differences. In this study, we attempt to characterize this potential variation....Brain stimulation - Therapeutic use - Research; Depression, Mental - Treatment - Research; Deep brain stimulation; Depressive brain circuitry; Fiber tracts; Tractography2016-05
11 Luo, ShirleyDevelopment of a bioabsorbalbe active release antimicrobial coating for orthopedic implantsOrthopedic implantations often create an opportunity for biofilm-related infections to arise. Patients infected with biofilm must often undergo additional surgeries for repair or replacement, which puts them at a greater risk of osteomyelitis, sepsis, and other complications including death [17]. T...Orthopedic implants - Research; Anti-infective agents - Research; Staphyloccoccal infections - Prevention and control - Research; Antimicrobial coating; Staphylococcus aureus2016-05
12 Radhakrishnan, SridharanDevelopment of Low-Cost system for Myoelectric Prosthesis ControlThe upper limb prosthetics field has advanced to where artificial hands can mimic human motions based on electrical signals emitted from muscular activation and can even open and close proportionate to the amplitude of signal they receive. However, these prostheses are very expensive, with some cost...2020
13 Hyer, Christina CottrellEffect of M1 Matrix Protein on Hemagglutinin Expression and Influenza Virus-Like Particle Production in Trichoplusia NIVirus-like particles (VLPs) are a new and effective flu vaccine approach. VLPs are non-infectious and can produce robust immune responses. Flu VLPs are typically created by co-expressing the flu hemagglutinin (HA) surface antigen and the matrix protein M1-which assists in viral and VLP budding-in cu...2017
14 Grimmett, RollinEffects of Hypoxia and High Fat Diet on D. Melanogaster Heart PhysiologyHeart disease severely affects millions of people worldwide, and is caused by various environmental and genetic factors. The aim of this study is to examine the combined physiological effects of hypoxia and a high fat diet (two known causes) on Drosophila Melanogaster heart structure. Sets of adult ...2017
15 Sedley, AndrewEgocentric Navigation in a Morris Water Maze for Testing Memory Formation in MiceMouse models are crucial to understanding not only sensory and cognitive neurological processes, but also diseases, disabilities, and responses to pharmacological or surgical treatments. Behavioral tests are essential assets in the description of these models. The Morris Water Maze is a common behav...2018
16 Ruan, TingEndogenous ceramide contributes to cardiovascular complications in Type II diabetes by decreasing the association between PP2A and I2PP2ACardiovascular complications are the leading cause of death in individuals with conditions associated with insulin resistance, e.g. type 2 diabetes, diet-induced obesity. In patients with type 2 diabetes, cardiovascular complications are 2-4 times more prevalent. One common cardiovascular complicati...Ceramides - Physiological effect; Diabetic angiopathies2014
17 Flach, BrianExamining the effects of whisker trimming on mouse brain cell growthHoxb8 microglia are a particular breed of scavenger cells in the brain which have been related to obsessive compulsive disorder (OCD)-like behavior among other behavioral disorders. These cells have been found to reach full maturity during a period of neurological development known as the critical ...Obsessive-compulsive disorder - Research; Microglia - Research; Mice as laboratory animals - Research; Whiskers; Scavenger cells; Hoxb8 microglia2016-04
18 Waller, Rosalie G.Exome sequence comparison of seventy-seven multiple myeloma cases identifies potential risk allelesMultiple Myeloma (MM) is a heritable cancer of plasma cells with poor prognosis. Although a few genomic risk-loci have been identified for MM, no risk variants have been published that explain MM heritability. We hypothesize MM heritability is due to rare germ-line variants that can be discovered th...Multiple myeloma -- Genetic aspects; Exomes; Exome sequence; Risk alleles2015-05
19 Black, Taylor MadisonImpacts of Tobacco Smoke Exposure and Outlier Body Mass Indices on Pediatric Asthma OutcomesThere are seven million children in the United States impacted by asthma [1]. When assessing the severity of a child's asthma, it is important to take into account risk factors known to affect child hood asthma. Two such risk factors that are modifiable include parental tobacco smoke exposure (TSE)...Asthma - Child; Tobacco smoke - Health aspects - United States2015-05
20 Thomas, Payton JImportance sampling techniques for genetic circuit analysisGenetic circuits have been identified as a promising technology that could revolutionize several areas, including biofuels, biomanufacturing, and medicine. Despite the tremendous potential of this technology, there are significant challenges associated with its development and implementation. One of...2023
21 Lei, Jeffrey KaChonIncreased gluti expression in mouse cardiomyocytes preserves mitochondrial function but is insufficient to attenuate pressure overload-induced contractile dysfunctionLifelong over-expression of GLUT1 transporter in the heart has been shown to preserve contractile function after aortic constriction. However it is unclear whether this protective effect is due to GLUT1 overexpression itself or due to reprogramming of heart metabolism as a result of long-term increa...Bioengineering2013-04
22 Koblanski, KasperLiver foxn3 increases pancreatic a-cell mass without altering hepatic amino acid utilizationInsulin injection into peripheral tissues inefficiently controls elevated fasting blood glucose in type 1 diabetes mellitus (DM1) patients. Peripheral insulin lacks the signaling of healthy β-cell insulin, which directs adjacent pancreatic α-cells to stop production of glucagon, a hormone releasin...2022
23 Citterman, Abigail R.Low frequencies improve intensity discrimination for electrocutaneous artificial sensory feedbackThe current standard of care for those living with upper-limb loss is unsatisfactory, with up to 50% of amputees abandoning their prostheses, citing unintuitive use and a lack of sensory feedback as critical factors. Electrocutaneous stimulation uses electrodes on the skin to evoke tactile sensation...2022
24 Harding, Anna NeiblingLow-Cost Surface Electromyogtraphy Sleeve for Quick and Repeatable Decoding of Motor IntentSurface electromyography (sEMG) is a noninvasive way to decode motor intent for applications such as prosthesis control, virtual reality, and stroke or spinal cord rehabilitation. State-of-the-art methods of decoding motor intent used in myoelectric prostheses have limited capabilities, partially du...2019
25 Armstrong, Blair P.Lower critical solution temperature behavior of elastin-coiled-coil polymer, a potential platform for treatment of non-hodgkin's lymphomaNon-Hodgkin's lymphoma takes the lives of 20,000 Americans each year. When traditional therapies fail, clinicians have turned to a drug, rituximab, for treatment. However, rituximab is now curative for less than 50% of patients and new treatments are needed. Drug-free macromolecular therapeutics (DF...2021
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