| | Title | Creator | Description | Subject | Date |
|---|
| 1 |  | Analysis of circular bordered pit function I. Angiosperm vessels with homogenous pit membranes | Sperry, John S. | A model predicted pit and vessel conductivity, the air-seed pressure for cavitation, and the implosion pressure causing vessel collapse. Predictions were based on measurements from 27 angiosperm species with circular bordered pits and air-seed pressures of 0.2-11.3 MPa. Vessel implosion pressure exc... | Functional wood anatomy; hydraulic architecture; plant biomechanics | 2004 |
| 2 |  | Analysis of circular bordered pit function II. Gymnosperm tracheids with torus-margo pit membranes | Sperry, John S. | A model of xylem conduit function was applied to gymnosperm tracheids with torus-margo pit membranes for comparison with angiosperm vessels. Tracheids from 17 gymnosperm tree species with circular bordered pits and air-seed pressures from 0.8 to 11.8 MPa were analyzed. Tracheids were more reinforced... | Functional wood anatomy; hydraulic architecture; plant biomechanics | 2004 |
| 3 |  | Analysis of the roles of microtubules and actin in erythrophore intracellular motility | Beckerle, Mary C. | The Holocentrus erythrophore, a red pigment cell, represents a model system for the study of organized intracellular transport. We have investigated the possibility that microtubules and actin are integral components of the pigment translocating motility machine. | Actin; Actomyosin; Erythrophore; Pigment | 1983 |
| 4 |  | Sensitivity of the Colorado plateau to change: climate, ecosystems, and society | Ehleringer, James R.; Belnap, Jayne | The Colorado Plateau is located in the interior, dry end of two moisture trajectories coming from opposite directions, which have made this region a target for unusual climate fluctuations. A multidecadal drought event some 850 years ago may have eliminated maize cultivation by the first human settl... | Colorado Plateau; Biological crust; Climate change; Megadrought; Ranching; Dry crop productivity; Extractive industries; Pueblo Indians; Fremont culture | 2008 |
| 5 |  | Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1 | Capecchi, Mario R. | Mouse selenoprotein P (Sepp1) consists of an N-terminal domain (residues 1-239) that contains 1 selenocysteine (U) as residue 40 in a proposed redox-active motif (-UYLC-) and a Cterminal domain (residues 240-361) that contains 9 selenocysteines. Sepp1 transports selenium from the liver to other tiss... | | 2014-01-01 |
| 6 |  | Sexual dimorphism in the Hymenoptera | Seger, Jon | Spectacular sex differences of many kinds occur abundantly among the wasps, bees and ants that make up the insect order Hymenoptera. In some cases these differences are so extreme that males and females of the same species have been classified in different genera for decades, until a chance observa... | Reproductive; Insect; Morphology | 1994 |
| 7 |  | Shoot dieback during prolonged drought in Ceanothus (Rhamnaceae) chaparral of California: a possible case of hydraulic failure | Sperry, John S. | Progressive diebacks of outer canopy branchlets of Ceanothus crassifolius were repeatedly observed after rainless periods up to 9 mo in duration in the Santa Monica Mountains of southern California. Mean xylem pressures of branchlets near the end of drought were as low as -11.2 MPa (N = 22) with a m... | Water relations; xylem cavitation; water-stress-induced loss | 2002 |
| 8 |  | Quorum sensing primes the oxidative stress response in the insect endosymbiont, Sodalis glossinidius | Dale, Colin; Babst, Markus | Sodalis glossinidius, a maternally transmitted bacterial endosymbiont of tsetse flies (Glossina spp.), uses an acylated homoserine lactone (AHL)-based quorum sensing system to modulate gene expression in accordance with bacterial cell density. The S. glossinidius quorum sensing system relies on the... | Endosymbionts; Sodalis glossinidius; Quorum sensing; Oxidative stress response | 2008 |
| 9 |  | A birders quide to Turkey | Sekercioglu, Cagan | As I write, it is early December and the woods outside my window lay dusted with snow like a holiday card by Currier and Ives. A minute ago, I looked up and caught a glimpse of an adult Cooper's Hawk dashing swiftly through the trees. It swooped up, landed on a branch, then briefly shook its tail an... | | 2006-01-01 |
| 10 |  | White-crowned sparrows tutored with syllable pairs can produce full songs | Goller, Franz | During their 'sensitive period', young songbirds develop an 'acquired template', representing a memory of the song(s) that it hears. Later, during the sensorimotor phase, birds use this template to evaluate, via auditory feedback, their vocalizations. | Acquired template; Sensorimotor period; Temporal isolation | 2003 |
| 11 |  | Recent rapid increases in the right whale (Eubalaena australis) population off southern Brazil | Adler, Frederick R. | Right whales (Eubalaena australis) that gather on a wintering ground off southern Brazil have been aerial surveyed and photographically identified since 1987. As of 2003 the Brazilian Right Whale Catalogue has 315 different individual whales of which 31 were resighted in other years (23 females, 3 y... | | 2005 |
| 12 |  | Processing of adenovirus 2-induced proteins | Gesteland, Raymond F. | Analysis of (35)S-methionine-labeled extracts of adenovirus 2-infected KB cells revealed 22 virus-induced polypeptide components. Most proteins of the virion were easily detected in extracts of whole cells labeled for short periods between 15 and 30 h after infection; however, several virion compone... | Adenoviridae; Viral Proteins; Protein Precursors; Methionine; Mouth Neoplasms | 1973 |
| 13 |  | Origin and destiny of adenovirus proteins | Gesteland, Raymond F.; Atkins, John F. | Lytic infection of human cells by adenovirus proceeds by a temporal expression of genes. Classically two phases have been defined: an early phase, which includes events occurring before the onset of DNA synthesis (8 hours), and a late phase, including events whose existence depends on the onset of... | Protein Biosynthesis; DNA, Viral; Adenoviridae; RNA, Viral; Time Factors | 1975 |
| 14 |  | Simian virus 40-specific polypeptides in Ad2+ND4- infected cells | Gesteland, Raymond F. | A comparison of the proteins synthesized in human cells at late times after infection with adenovirus (Ad2) and with the adeno-simian virus 40 (SV40) hybrid viruses revealed polypeptides of 30,000 and 92,000 molecular weight specific for the hybrid viruses Ad2+ND1 and Ad2+ND4, respectively. Cell-fre... | Molecular Weight; Peptide Biosynthesis; RNA, Messenger; Viral Proteins | 1976 |
| 15 |  | Evolutionary specialization of recoding: frameshifting in the expression of S. cerevisiae antizyme mRNA is via an atypical antizyme shift site but is still +1 | Gesteland, Raymond F.; Atkins, John F. | An autoregulatory translational shift to the +1 frame is required for the expression of ornithine decarboxylase antizyme from fungi to mammals. In most eukaryotes, including all vertebrates and a majority of the studied fungi/yeast, the site on antizyme mRNA where the shift occurs is UCC-UGA. The me... | Antizyme; ODC; Polyamines; Frameshifting | 2006 |
| 16 |  | Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene. | Thomas, Kirk R.; Capecchi, Mario R. | Injection of homologous DNA sequences into nuclei of cultured mammalian cells induces mutations in the cognate chromosomal gene. It appears that these mutations result from incorrect repair of a heteroduplex formed between the introduced and the chromosomal sequence. This phenomenon is termed 'heter... | Animals; Cell Line; Drug Resistance, Microbial; Fibroblasts; Mice; Models, Genetic; Neomycin; Plasmids | 1986-11-06 |
| 17 |  | Fgf8 is required for outgrowth and patterning of the limbs. | Moon, Ann M.; Capecchi, Mario R. | The expression pattern and activity of fibroblast growth factor-8 (FGF8) in experimental assays indicate that it has important roles in limb development, but early embryonic lethality resulting from mutation of Fgf8 in the germ line of mice has prevented direct assessment of these roles. Here we rep... | Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm | 2000-12-26 |
| 18 |  | Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian. cell nuclei | Thomas, Kirk R.; Capecchi, Mario R. | We have examined the mechanism of homologous recombination between plasmid molecules coinjected into cultured mammalian cells. Cell lines containing recombinant DNA molecules were obtained by selecting for the reconstruction of a functional Neor gene from two plasmids that bear different amber mutat... | Animals; Cells, Cultured; DNA Restriction Enzymes; Kinetics | 1985-01 |
| 19 |  | Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. | Hansen, Mark S.; Coffin, Cheryl M.; Capecchi, Mario R. | To investigate the role of the translocation-associated gene Pax3:Fkhr in alveolar rhabdomyosarcomas, we generated a Cre-mediated conditional knock-in of Pax3:Fkhr into the mouse Pax3 locus. Exploring embryonic tumor cell origins, we replaced a Pax3 allele with Pax3:Fkhr throughout its expression do... | Neuroprogenitor; Embryogenesis | 2004-11-01 |
| 20 |  | Targeting genes for self-excision in the germ line | Capecchi, Mario R.; Bernstein, Kenneth E.; Thomas, Kirk R. | A procedure is described that directs the self-induced deletion of DNA sequences as they pass through the male germ line of mice. The testes-specific promoter from the angiotensin-converting enzyme gene was used to drive expression of the Cre-recombinase gene. Cre was linked to the selectable marker... | Cre-recombinase; Hoxa3; Chimeric mice | 1999-06-15 |
| 21 |  | Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. | Capecchi, Mario R.; Mansour, Suzanne L.; Thomas, Kirk R. | Gene targeting--homologous recombination of DNA sequences residing in the chromosome with newly introduced DNA sequences--in mouse embryo-derived stem cells promises to provide a means to generate mice of any desired genotype. We describe a positive nd negative selection procedure that enriches 2,00... | Animals; Clone Cells; Restriction Mapping; Stem Cells | 1988-11-24 |
| 22 |  | Maintenance of functional equivalence during paralogous Hox gene evolution. | Thomas, Kirk R.; Capecchi, Mario R. | Biological diversity is driven mainly by gene duplication followed by mutation and selection. This divergence in either regulatory or protein-coding sequences can result in quite different biological functions for even closely related genes. This concept is exemplified by the mammalian Hox gene comp... | Alleles; Animals; Cervical Vertebrae; Embryo; Genetic Complementation Test; Homeodomain Proteins; Homozygote; Mice | 2000-02-10 |
| 23 |  | Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. | Thomas, Kirk R.; Capecchi, Mario R. | The int-1 proto-oncogene was first identified as a gene activated in virally induced mouse mammary tumours. Expression studies, however, suggest that the normal function of this gene may be in spermatogenesis and in the development of the central nervous system. Genes sharing sequence similarity wit... | Animals; Blastocyst; Cell Line; Chimera; DNA; Female; Genotype; Heterozygote; Homozygote; Male; Mice, Inbred C57BL; Motor Activity | 1990-08-30 |
| 24 |  | Mouse model for the delta F508 allele of cystic fibrosis | Eichwald, Ernst; Capecchi, Mario R.; Thomas, Kirk R. | The most common cause of cystic fibrosis is a mutation that deletes phenylalanine 508 in cystic fibrosis transmembrane conductance regulator (CFTR). The delta F508 protein is misprocessed and degraded rather than traveling to the apical membrane. We used a novel strategy to introduce the delta F508 ... | Digestive System; Disease Models, Animal; Electrolytes; Mice, Inbred C57BL | 1995-10 |
| 25 |  | Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. | Coffin, Cheryl M.; Capecchi, Mario R. | Alveolar rhabdomyosarcoma is an aggressive childhood muscle cancer for which outcomes are poor when the disease is advanced. Although well-developed mouse models exist for embryonal and pleomorphic rhabdomyosarcomas, neither a spontaneous nor a transgenic mouse model of alveolar rhabdomyosarcoma has... | Cell Differentiation; Forkhead Transcription Factors; Myogenic Regulatory Factors | 2004-11-01 |
