1 - 25 of 109
Number of results to display per page
CreatorTitleDescriptionSubjectDate
1 Normann, Richard A.; Campbell, Patrick K.; Jones, Kelly E.100 electrode intracortical array: structural variabilityA technique has been developed for fabricating three dimensional "hair brush" electrode arrays from monocrystalline silicon blocks. Arrays consist of a square pattern of 100 penetrating electrodes, with 400 microns interelectrode spacing. Each electrode is 1.5mm in length and tapers from about 100 m...Microelectrode arrays; Stimulation; Micromachining1990
2 Horch, Kenneth W.; Christensen, Douglas A.Accelerated 4-year bachelors/masters degree program in biomedical engineeringIn response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g...Accelerated dual-degree program2002
3 Horch, Kenneth W.; Christensen, Douglas A.Accelerated 4-year bachelors/masters degree program in biomedical engineeringIn response to the need for providing advanced engineering education in a shorter time period than is currently possible by traditional curricula, we have created an Accelerated Dual Degree program in biomedical engineering. The purpose of this pilot program is to attract the brightest students, g...Accelerated; Dual-degrees; Education2002
4 Christensen, Douglas A.; Horch, Kenneth W.Accelerated dual-degree BS/MS program - experience with the first three yearsWe have initiated a pilot program that accelerates the studies of a small group of highly qualified students early in their college careers and allows them to earn both a bachelor's degree and a master's degree in about four years after starting college. It does this by introducing them early to res...Accelerated dual-degree program2004
5 Christensen, Douglas A.Acoustic droplet vaporization, cavitation, and therapeutic properties of copolymer-stabilized perfluorocarbon nanoemulsionsAcoustic and therapeutic properties of Doxorubicin (DOX) and paclitaxel (PTX)-loaded perfluorocarbon nanoemulsions have been investigated in a mouse model of ovarian cancer. The nanoemulsions were stabilized by two biodegradable amphiphilic block copolymers that differed in the structure of the hydr...Cancer therapy; Targeted drug delivery; Nanobubbles; Ultrasound; Perfluoropentane2009
6 Horch, Kenneth W.Acoustic interneurons of fiddler and ghost crabsThe properties of acoustic interneurons in fiddler (Uca pugilalor and U. minax) and ghost (Ocvpade qucldrula) crabs are described, as revealed bv tests with pure tones. Three types of interneurons were present in all species: tonic, which fired for the duration of the stimulus; phasic, which fire...Acoustic crabs; Neural recording; Vibration reception1976
7 Horch, Kenneth W.Action potential classification with dual channel intrafascicular electrodesUsing recordings of peripheral nerve activity made with carbon fiber intrafascicular electrodes, we compared the performance of three different recording techniques (single channel, differential, and dual channel) and four different unit classification methods (linear discriminant analysis, temp...Carbon fiber intrafascicular electrodes; Dual channel recording1994
8 Horch, Kenneth W.; Lawrence, Steve M.; Dhillon, Gurpreet S.Acute peripheral nerve recording characteristics of polymer-based longitudinal intrafascicular electrodesWe examined the recording characteristics of two different types of polymer-based longitudinal intrafascicular electrodes (LIFEs) in peripheral nerve: single-stranded (s-polyLIFEs) and multistranded (m-polyLIFEs). Recordings were also made from Pt-Ir wire-based electrodes (PtIrLIFEs) as a control. T...Sciatic Nerve; Intrafascicular Electrodes, Peripheral Nerve Recording2004
9 Horch, Kenneth W.Are the extrinsic muscles better suited for signaling joint angles or finger tip location?We used a biomechanical model of the human long finger to determine whether the extrinsic muscles are better suited for estimating the finger's joint angles or for estimating location of the finger tip. We found that two of the extrinsic muscles together could provide information sufficient to direc...Extrinsic muscles; Metacarpophalangeal joint; Biomechanical models1997
10 Gesteland, Raymond F.; Ives, Jeffrey T.; Stockham, Thomas G.Automated film reader for DNA sequencing based on homomorphic deconvolutionAn automated reader for electrophoresis based DNA sequencing methods is described that provides fast and accurate sequence determination. Digitized sequencing lanes are processed with homomorphic blind deconvolution in preparation for peak detection, interlane alignment, peak refinement and base cal...Sequence Analysis; Electrophoresis; Automated Film Reader; Homomorphic Deconvolution1994
11 Christensen, Douglas A.Biosensor development at the University of UtahInterest in biosensors has increased rapidly in the past few years due to the many potential advantages of these devices, such as small size, speed of response, and specificity 111. The term "biosensor" in the broad sense describes any device or apparatus which detects biological signals for the pu...Silicon retina; Photosensing array; CHEMFET; Fluorescence lmmunosensor; Planar waveguide1994-07
12 Christensen, Douglas A.Bringing an integrative modeling experience to a freshman biomedical engineering courseAs an integrating lab experience in our Fundamentals of Bioengineering freshman course, we have included a Major Project that ties together many of the principles of biomechanics and bioelectricity covered in the lecture. It uses the human systemic cardiovascular system as a model. During the first...Matlab2004
13 Gesteland, Raymond F.Cell-free synthesis of herpes simplex virus proteinsPolyribosomes isolated from herpes simplex virus type I (HSV-1)-infected cells have been used to program a eucaryotic cell-free translation system. At least 10 HSV-specific polypeptides, with apparent molecular weights of 25,000 to 160,000, are synthesized by wild-type HSV-infected polyribosomes. Po...Viral Proteins; Herpes Simplex; Peptide Biosynthesis; Thymidine Kinase1977
14 Horch, Kenneth W.Changes in primary afferent depolarization of sensory neurones during peripheral nerve regeneration in the catI. Micro-electrode recordings were made from normal and regenerating sural nerve fibres in cats. Increases in the excitability of the central terminals of these fibres after conditioning stimulation of other sural nerve fibres were taken as evidence for primary afferent depolarization. 2. At all...Micro-electrode recording; Nerve regeneration; Primary afferent depolarization1981
15 Collins, Zachary J.; Poelzing, StevenCharacterization of a four-camera ratiometric optical mapping systemElectrical activity precedes calcium mediated heart contractions. Optical mapping takes advantage of minimally invasive fluorescent molecular probes to image both electrical and calcium activity. These molecular probes allow for ratiometric imaging. We characterize a four camera system capable of...Optical mapping; Ratiometric imaging; Di-4-ANEPPS; Indo-1; Trapeze Interactive Poster2010-03-15
16 Gesteland, Raymond F.Characterization of lysozyme messenger and lysozyme synthesized in vitroIn vitro systems for protein systhesis have been in wide use for about 10 years. In most of the early work protein synthesis was measured by following the incorporation of radioactive amino acids into acid precipitable material. This test cannot distinguish between the synthesis of complete, activ...Lysozyme Messenger; Lysozyme Synthesized; Protein Synthesis1969
17 Angelucci, Alessandra; Lund, Jennifer S.Circuits for local and global signal integration in primary visual cortexContrast-dependent changes in spatial summation and contextual modulation of primary visual cortex (V1) neuron responses to stimulation of their receptive field reveal long-distance integration of visual signals within V1, well beyond the classical receptive field (cRF) of single neurons. To identif...Primary Visual Cortex; Extrastriate Cortex; Feed-back Connections; Lateral Connections; SUrround Modulation; Macaque2002-10-01
18 Horch, Kenneth W.Classification of action potentials in multi unit intrafascicular recordings using neural network pattern recognition techniquesNeural network pattern-recognition techniques were applied to the problem of identifying the sources of action potentials in multi-unit neural recordings made from intrafascicular electrodes implanted in cats. The network was a three-layer connectionist machine that used digitized action potenti...Intrafascicular electrodes; Multi-unit neural activity; Artificial neural networks1994
19 Horch, Kenneth W.Closed loop control of ankle position using muscle afferent feedback with functional neuromuscular stimulationThis paper describes a closed-loop functional neuromuscular stimulation system that uses afferent neural activity from muscle spindle fibers as feedback for controlling position of the ankle joint. Ankle extension against a load was effected by neural stimulation through a dual channel intrafasc...Neuromuscular stimulation; Functional neuromuscular stimulation (FNS); Neural electrodes1996
20 Christensen, Douglas A.; Herron, James N.Comparison of robust coupling techniques for planar waveguide immunosensorsWe have analyzed and fabricated two different coupling schemes to meet the requirements for a convenient means of coupling into a planar waveguide immunosensor that is relatively insensitive to beam alignment. These are the "launch" coupler and the grating coupler. Each possesses advantages and dis...Planar waveguide immunosensors; Fluorescence; Launch coupler; Grating coupler1993
21 Christensen, Douglas A.Computer-aided design of two-dimensional electric-type hyperthermia applicators using the finite-difference time-domain methodA hyperthermia applicator design tool consisting of a finite-difference time-domain (FDTD) technique in combination with a graphical display of electric fields and normalized linear temperature rise is described. This technique calculates, rather than assumes, antenna current distributions; it incl...Finite-difference time-domain method; Hyperthermia applicator1991-09
22 Horch, Kenneth W.Control of ankle position using neural feedbackThis paper describes a closed loop control system that uses afferent neural activity from muscle spindle fibers as feedback for controlling ankle position. The gastrocnemius muscle was stimulated through a dual channel intrafascicular electrode implanted in a fascicle of the tibial nerve. Dual cha...Neuromuscular stimulation; Peripheral nerve; Joint angle1994
23 Gesteland, Raymond F.; Krapcho, Karen J.; Talbot, Phil; Thulin, CraigCrystallization of the MS2 translational repressor alone and complexed to bromouridineThe coat protein from the MS2 bacteriophage plays a dual role by encapsidating viral RNA and also by binding RNA as a translational repressor. In order to study the isolated dimer in a conformation not influenced by capsid interactions, a mutant molecule was crystallized that is defective in capsid ...Crystallization; RNA Bacteriophage; RNA Hairpin; Translational Repressor1995
24 Horch, Kenneth W.Differential activation of nerve fibers with magnetic stimulation in humansEarlier observations in our lab had indicated that large, time-varying magnetic fields could elicit action potentials that travel in only one direction in at least some of the myelinated axons in peripheral nerves. The objective of this study was to collect quantitative evidence for magnetically in...Magnetic stimulation; Peripheral nerve; Electromyographic potential; Somatosensory potential2006
25 Horch, Kenneth W.; Dhillon, Gurpreet S.Direct neural sensory feedback and control of a prosthetic armEvidence indicates that user acceptance of modern artificial limbs by amputees would be significantly enhanced by a system that provides appropriate, graded, distally referred sensations of touch and joint movement, and that the functionality of limb prostheses would be improved by a more natural co...Peripheral Nerve Implant; Prosthetic Limb Control; Sensory Feedback2005-12
1 - 25 of 109