| | Title | Author | Subject | Description | Date |
|---|
| 1 |  | Immune-tolerant elastin-like polypeptide-delivered chemotherapeutics and immunotherapeutics for treatment of cancer | Zhao, Peng | antibody; cancer; elastin-like polypeptides; immunotherapy; PD-1; protein | As a nonimmunogenic biopolymer with diverse functions, immune-tolerant elastin-like polypeptides (iTEPs) have great potential to serve delivery systems for small molecules and for protein therapeutics. Lack of immunogenicity avoids possible neutralizing humoral immune responses that compromise thera... | 2018 |
| 2 |  | Polysulfide-based biodegradable silica nanoparticles: synthesis, characterization, and biological fate | Moghaddam, Seyyed Pouya Hadipour | | Silica nanoparticles (SiO2 NPs) have attracted attention for delivery of bioactive and imaging agents due to their stability, robustness, ease of synthesis and scale up and the ability to protect active pharmaceutical ingredients. For these constructs to advance to clinical use detailed understandin... | 2019 |
| 3 |  | Immune-tolerant elastin-like polypeptide (ITEP) for delivering cancer immunotherapy | Wang, Peng | antibodies; cancer immunotherapy; drug delivery systems; immune-tolerant elastin-like polypeptides; vaccines | Cancer vaccines and immune checkpoint antibodies are two types of cancer immunotherapy. This dissertation describes the development of drug delivery systems that can improve the efficacy of vaccines and antibodies for cancer treatment. These drug delivery systems are derived from immune-tolerant ela... | 2019 |
| 4 |  | Impact of silica nanoparticle design of sedimentation, cellular uptake, cytotoxicity, and gene expression | Yazdimamaghani, Mostafa | Gene expression; macrophage response; nanotoxicity; physicochemical properties; RNA-sequencing; silica nanoparticles | Advances in the synthesis and characterization of engineered silica nanoparticles (SNPs) are not matched by careful assessment of their effects on biological systems, environmental health, and safety. Better understanding of how silica nanoparticles interact with biological fluids and cells is requi... | 2018 |
| 5 |  | Development of fluorescent and luminescent probes to investigate biointerfaces in Breast Cancer | Kim, Sun Jin | human genome project; CD44; HER2; EGFR; homogeneous immunoassay; adenocarcinoma | The Human Genome Project has revealed that the human body has about 25,000 genes. Of these genes, about 20,000 are known as protein-coding genes. If protein splicing and polymorphisms are taken into consideration, the number of proteins involved in human physiology is estimated to be in the billions... | 2019 |
| 6 |  | Neonatal drug delivery and disposition: towards improving care for the youngest patients | Linakis, Matthew Wiliiam | Pharmacology; Pharmaceutical sciences | Research in pediatric medicine has undergone a significant and beneficial transformation in the past several years. However, neonates (birth to 27 days of age) are still administered drugs off-label far too often, and there is a paucity of data supporting safe and effective use of many drugs in this... | 2018 |
| 7 |  | Translocation of silver through epithelial cell barriers | Falconer, Jonathan Leslie | Pharmaceutical sciences | Silver has a long history as an antimicrobial, and its use in clinical and consumer products continues to increase. Clinical silver biomaterials have achieved mixed rates of success while nanosilver consumer products in textiles, intranasal sprays, and oral liquid products are sold without significa... | 2017 |
| 8 |  | Cell surface engineering and its applications in cancer therapy | Daniel Yongwon Lee | Cellular biology; Biomedical engineering; Pharmaceutical sciences | Remodeling of cell surface to install new features has continuously attracted attention for cell therapy. This dissertation focuses on a method of cell surface engineering using bioactive molecules to transiently award distinct functions to ordinary cells. Spontaneous incorporation of lipid-conjugat... | 2017 |
| 9 |  | Stimuli-responsive polymers and their applications in Gene delivery | Hwang, Hee Sook | health and environmental sciences; Gene delivery; stimuli-responsive polymers | Polymeric gene delivery is introducing specific genes to enhance or silence gene expression using synthesized polymers which have low immunogenicity and good biocompatibility. This dissertations specifically focused on the synthesis and characterization of stimuli-responsive polymers for gene delive... | 2015-12 |
| 10 |  | Abrogation of liver cancer with thermal ablation and targeted heat shock inhibition | Chen, Yizhe | Health and environmental sciences; heat shock proteins; hepatocellular carcinoma; tumor cells | Thermal ablation is widely used, first line local-regional therapy for unresectable hepatocellular carcinoma (HCC). Although high temperature delivered by thermal energy results in efficient coagulation necrosis in tumor cells, various factors including tumor size, shape, location, and cirrhosis can... | 2015-05 |
| 11 |  | Development of safe and effective magnetic resonance contrast agents for blood pool imaging and cancer diagnosis | Ye, Zhen | health and environmental sciences; blood pool imaging; cancer diagnosis; magnetic resonance | The current commercialized Gd(III)-based magnetic resonance (MR) contrast agents are small molecules characterized with short blood half-life and nonspecific tissue distribution. The accuracy of MR diagnosis involving clinical contrast agents is often hindered because of a short diagnostic window an... | 2016-05 |
| 12 |  | Reversible inhibition of lysine-specific demethylase 1 is a novel therapeutic strategy for solid tumors | Theisen, Emily Rose | health and environmental sciences; endometrial carcinoma; epigenetics; Ewing sarcoma; experimental therapeutics; high throughput virtual screening; pharmaceutics | Cancer is a genomic disease driven by interplay between genetic and epigenetic factors. While genetic mutations are irreversible events, epigenetic regulation is dynamic and reversible, and small molecule blockade of the epigenetic machinery has shown clinical benefit in hematological malignancies. ... | 2015-05 |
| 13 |  | Modified coiled-coil proteins for the treatment of chronic myeloid leukemia | Bruno, Benjamin James | Pharmaceutical sciences; Physiology | Chronic myeloid leukemia (CML) is caused by the constitutive tyrosine kinase activity of the oncoprotein Bcr-Abl. This aberrant kinase activity activates a multitude of oncogenic signaling pathways resulting in myeloid cell proliferation. In the early 2000s, the development of tyrosine kinase inhibi... | 2017 |
| 14 |  | Combination nanomedicine targeting cancer stem cells and bulk tumor cells for treatment of prostate cancer | Zhou, Yan | health and environmental sciences; cancer stem cells; HPMA; nanomedicine; prostate cancer | Prostate cancer is the most common malignancy and second leading cause of cancer-related deaths in men in the United States. Despite improved management of patients with early stage prostate cancer, the mortality rate is still high due to frequent relapse, progression and metastasis following curren... | 2014-08 |
| 15 |  | Bypassing transdominant inhibition with chimeric p53 for cancer gene therapy | Okal, Abood | biological sciences; health and environmental sciences; apoptosis; breast cancer | It is well documented that more than 50% of all human cancers have a mutated p53 gene status, rendering it inactive. The resulting tumor-derived p53 variants, similar to wild-type (wt) p53, retain their ability to oligomerize via the tetramerization domain. Upon hetero-oligomerization, mutant p53 en... | 2014-08 |
| 16 |  | Stimuli-responsive targeted therapeutics for treatment of primary and metastatic prostate cancer | Peng, Zheng-Hong (Joseph) | Oncology | Prostate cancer is the most common malignant cancer and the second leading cause of cancer-related death among men in the United States. The major aim of this dissertation was to develop stimuli-responsive, targeted therapeutics for prostate cancer treatment. In the first part, 2-[3-(1,3-dicarboxypr... | 2014-08 |
| 17 |  | Matrix metalloproteinase responsive silk-elastinlike protein polymers for cancer gene therapy | Price, Robert Andrew | biological sciences; health and environmental sciences; adenovirus; cancer; depot; drug delivery; protein polymer; recombinant | Treatment methodologies employed in the management of head and neck cancer must be carefully chosen and matched to each patient. Currently, surgical resection with adjuvant chemotherapy and radiation are the standard of care; however, these often cause disfigurement and scarring in addition to the t... | 2015-05 |
| 18 |  | Inhibition of native and mutant BCR-ABL using a rationally designed coiled-coil | Miller, Geoffrey D. | health and environmental sciences; BCR-ABL; chronic myeloid leukemia; coiled-coil; ponatinib; stapled peptide | Chronic myeloid leukemia (CML) is caused by the constitutive kinase activity of the fusion oncoprotein BCR-ABL. Conventional therapy in CML utilizes tyrosine kinase inhibitors (TKIs), small molecules that target the ATP-binding pocket in the BCR-ABL kinase domain. Despite their success in treating t... | 2015-05 |
| 19 |  | Transport of a highly lipophilic weak acid molecule (capric acid) across a lipophilic membrane between two aqueous phases in the presence of a carrier (cyclodextrins) | Hymas, Richard Val | Pharmacy sciences | There has been a continuing need for a better quantitative understanding of the gastrointestinal absorption of highly lipophilic drugs. With this aim in mind, the present study describes a physical model approach applicable to understanding the transport of lipophilic, ionizable drugs across a lipop... | 2010 |
| 20 |  | Preventing neointimal hyperplasia perivascular drug delivery in synthetic hemodialysis grafts | Sanders, William G. | health and environmental sciences; arteriovenous hemodialysis grafts; monocyte chemotatic protein-1; monocytes | Hyperplasia leading to stenosis of synthetic vascular accesses for chronic hemodialysis is a widespread problem with no established treatment for prevention. Inflammation around the anastomotic region in hemodialysis arteriovenous (AV) grafts is a constant reoccurring factor that likely contributes ... | 2012-05 |
| 21 |  | Validating an ex vivo 3D kidney proximal tubule model for drug-induced nephrotoxicity screening | Diekjürgen, Dorina Eva Lisa | | Kidney toxicity is the second highest cause of new drug candidate failure, after liver toxicity, leading to drug withdrawals from the market and failed clinical trials. Therefore, development of more reliable and accurate in vitro screening systems for assessing drug nephrotoxicity is of high import... | 2017-08 |
| 22 |  | Working towards an optimized therapy for abnormal endometrial proliferation: treatment approaches and disease modeling | Almomen, Aliyah | | With the steadily increasing prevalence of endometrial hyperplasia (EH) and endometrial cancer (EC) among premenopausal women, the pursuit of improved conservative therapeutics is vitally important. Work in this dissertation attempts to optimize treatments for EH and EC through three different appro... | 2016-08 |
| 23 |  | Pharmacology and gating of SLO2.1, an intracellular Na+ activated potassium channel | Garg, Priyanka | | Slo2.1 is an intracellular Na+-regulated K+ channel that is abundantly expressed in the brain and the heart. Although Slo2.1 channels are believed to provide cardioprotection under ischemic conditions in the heart, the exact physiological or pathophysiological significance of these channels is still... | 2014-12 |
| 24 |  | Drug-free macromolecular therapeutics for treatment of B-Cell malignancies | Chu, Te-Wei | Biomedical engineering; Pharmacy sciences; Nanotechnology | Hybrid nanomaterials composed of synthetic and biological building blocks possess high potential for the design of nanomedicines. We propose a new therapeutic approach that mimics the mechanism of immune effector cells to crosslink surface receptors of target cells and induce apoptosis. The receptor... | 2015-08 |
| 25 |  | A peptide-based small interfering RNA delivery system as an RNA interference approach for neurodegenerative disorders | Youn, Pilju | Pharmaceutical sciences | Neurodegenerative disorders (NDDs) have become a major global health burden. Despite persistent advances in understanding the neurodegeneration process, pathogenesis has not been fully clarified and no cures are yet available. As a therapeutic approach for NDDs, RNA interference (RNAi) can be a pote... | 2015-05 |
