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1 Mitchell, Joyce A.Nanoinformatics: a new area of research in nanomedicineAbstract: Over a decade ago, nanotechnologists began research on applications of nanomaterials for medicine. This research has revealed a wide range of different challenges, as well as many opportunities. Some of these challenges are strongly related to informatics issues, dealing, for instance, wit...2012-01-01
2 Garber, SarahNeurosurgical complications of direct thrombin inhibitors - catastrophic hemorrhage after mild traumatic brain injury in a patient receiving dabigatranDabigatran etexilate is an oral anticoagulant that acts as a direct, competitive thrombin inhibitor. Large randomized clinical trials have shown higher doses of dabigatran (150 mg taken twice daily) to be superior to warfarin in terms of stroke and systemic embolism rates in patients with nonvalvula...2012-01-01
3 Mitchell, Joyce A.Personalized medicineWith the completion of the Human Genome Project in 2003, the world's attention has focused on converting this vast storehouse of information into innovative health care solutions. The ultimate promise, assuming we know everyone's genotype, is to ensure that every person has optimum health throughout...2007-01-01
4 Kendall, KatherineQuality of life scores compared to objective measures of swallowing function after oropharyngeal chemoradiationObjectives: To compare objective measures of swallowing function with patient reports of swallowing-related Quality of Life one year after treatment of oropharyngeal cancer with chemoradiation therapy. Study Design: Patients seen for follow-up at least one year after treatment of oropharyngeal carci...2014-01-01
5 Mitchell, Joyce A.Quality evaluation of controlled clinical information service trialsRandomized controlled clinical trials are increasingly accepted as tools of computer technology assessment and, therefore, quality evaluation of trials has great theoretical and practical significance. The purpose of this study was to assist the design of evaluation studies and synthesis of publishe...1993-01-01
6 Couldwell, William T.Response to Craniopharyngioma adherence to the hypothalamusTo The Editor: We have viewed with great interest the special supplement published by Neurosurgical Focus in January 2013 (Neurosurgical Focus, Video Atlas of Operative Surgery: Intraventricular Lesions: Microscopic and Endoscopic Approaches, Vol 34: January 2013) in which a compilation of videos de...2014-01-01
7 LaStayo, Paul C.Resistance exercise with older fallers: Its impact on intermuscular adipose tissueObjective. Greater skeletal muscle fat infiltration occurs with age and contributes to numerous negative health outcomes. The primary purpose was to determine whether intermuscular adipose tissue (IMAT) can be influenced by an exercise intervention and if a greater reduction in IMAT occurs with ecce...2014-01-01
8 Mitchell, Joyce A.Retrieval from full-text medical literature: the dream & the realityWhile the retrieval of the full-text of a document might seem to end all the hassle of using traditional retrieval systems, the results of the MEDLINE/Full-Text Project indicate that retrieval from the current full-text databases of biomedical journal literature does not match the dream. During the ...1991-01-01
9 Light, Alan R.Response to Letter by Dr. Smirmaul Group III/IV muscle afferents contribute to both perception of effort and fatigueWe thank Dr. Smirmaul for his interest in our findings, but advise caution not to over-interpret the data to address a question which would have required an entirely different study design. Specifically, the letter to the editor is strongly focused on effort perception, a variable which was, as expe...2014-01-01
10 Bernstein, Paul S.Skin carotenoid status measured by resonance Raman spectroscopy as a biomarker of fruit and vegetable intake in preschool childrenBackground/Objective: Dietary assessment in children is difficult, suggesting a need to develop more objective biomarkers of intake. Resonance Raman spectroscopy (RRS) is a noninvasive, validated method of measuring carotenoid status in skin as a biomarker of fruit/vegetable intake. The purpose of t...2012-01-01
11 Mitchell, Joyce A.Using information prescriptions to refer patients with metabolic conditions to the Genetics Home Reference websiteObjectives: The objectives of this study were to assess the reactions of adult patients and parents of children with metabolic conditions to receipt of an ‘‘information prescription'' (IP) to visit Genetics Home Reference (GHR), a National Institutes of Health/National Library of Medicine online...2011-01-01
12 Farrell, Timothy W.Organizational culture associated with provider satisfactionBackground: Organizational culture is key to the successful implementation of major improvement strategies. Transformation to a patient-centered medical home (PCHM) is such an improvement strategy, requiring a shift from provider-centric care to team-based care. Because this shift may impact provide...2014-01-01
13 Frederick, Jeanne M.The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular traffickingExpressed ubiquitously, PrBP/d functions as chaperone/co-factor in the transport of a subset of prenylated proteins. PrBP/d features an immunoglobulin-like b-sandwich fold for lipid binding, and interacts with diverse partners. PrBP/d binds both C-terminal C15 and C20 prenyl side chains of phototran...2012-01-01
14 Mitchell, Joyce A.Predicting phenotypic severity of uncertain gene variants in the RET Proto-OncogeneAlthough reported gene variants in the RET oncogene have been directly associated with multiple endocrine neoplasia type 2 and hereditary medullary thyroid carcinoma, other mutations are classified as variants of uncertain significance (VUS) until the associated clinical phenotype is made clear. Cur...2011-01-01
15 Mitchell, Joyce A.Preliminary evaluation of learning via the AI/LEARN/Rheumatology interactive videodisc systemAI/LEARN/Rheumatology is a level three videodisc system to teach clinical observational skills in three important diseases: rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. The AI/LEARN software was developed on an independent authoring system called GALE designed for MS-DOS based c...1992-01-01
16 Bernstein, Paul S.Senior-Løken syndrome: a syndromic form of retinal dystrophy associated with nephronophthisisSenior-Løken syndrome (SLS) is an autosomal recessive disease characterized by development of a retinitis (RP)- or Leber congenital amaurosis (LCA)-like retinal dystrophy and a medullary cystic kidney disease, nephronophthisis. Mutations in several genes (called nephrocystins) have been shown to ca...2012-01-01
17 Couldwell, William T.Sellar and parasellar metastatic tumorsThe sellar and parasellar (SPS) region is a complex area rich in vital neurovascular structures a first manifestation of a systemic malignancy. Metastases to this region are rare; breast cancer is the most common source among those that metastasize to the SPS region. Ophthalmoplegia, headache, retro...2012-01-01
18 Mitchell, Joyce A.Use of a microcomputer database system in a statewide effort for data collection in medical geneticsThe Genetics Office Automation System (GOAS) is a database management system for the collection and reporting of medical genetics data. We have previously reported on its implementation in a single university center [1,2]. We report here on its implementation in a coordinated data collection effort ...1991-01-01
19 Jensen, Randy LynnTreatment-related brain tumor imaging changes: so-called "pseudoprogression" vs. tumor progression: Review and future research opportunitiesBackground: Glioblastoma multiforme (GBM) has a dismal prognosis despite aggressive therapy. Initial diagnosis and measurement of response to treatment is usually determined by measurement of gadolinium-enhanced tumor volume with magnetic resonance imaging (MRI). Unfortunately, many GBM treatment mo...2013-01-01
20 Couldwell, William T.Transnasal excerebration surgery in ancient Egypt: Historical vignetteAncient Egyptians were pioneers in many fields, including medicine and surgery. Our modern knowledge of anatomy, pathology, and surgical techniques stems from discoveries and observations made by Egyptian physicians and embalmers. In the realm of neurosurgery, ancient Egyptians were the first to elu...2012-01-01
21 Couldwell, William T.Transtemporal approach to the removal of a lateral pontine tumorThis video demonstrates a very useful trajectory to a pontine lesion. A 68-year-old man presented with tongue numbness and weakness. The approach used was a transtemporal presigmoid retrolabyrinthine approach to enable an orthogonal trajectory to the lateral pons. Following the transtemporal opening...2014-01-01
22 Dwight, Zachary LawrenceuAnalyze: web-based high-resolution DNA melting analysis with comparison to thermodynamic predictionsAbstract-uAnalyzeSM is a web-based tool for analyzing high-resolution melting data of PCR products. PCR product sequence is input by the user and recursive nearest neighbor thermodynamic calculations used to predict a melting curve similar to uMELT (http://www.dna.utah.edu/umelt/umelt.html). Unproce...2012-01-01
23 Frederick, Jeanne M.Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteinsThe mechanism by which myristoylated proteins are targeted to specific subcellular membrane compartments is poorly understood. Two novel acyl-binding proteins, UNC119A and UNC119B, have been shown recently to function as chaperones/co-factors in the transport of myristoylated G protein a-subunits an...2012-01-01
24 Warner, Homer R.The HELP SystemBiomedical Informatics1983
25 Warner, Homer R.Decision Support in Medicine: Examples from the HELP SystemBiomedical Informatics1994
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