Title |
Thymus after cyclophosphamide treatment (rat) |
Creator |
Poels, Lambert G. |
Contributor |
Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen |
Date |
2010-06-11 |
Subject |
cyclophosphamide; immunosuppression; involution; lymphoid tissue |
Description |
Stain: Hematoxylin & eosin. A single injection with cyclophosphamide (CP, 4 70 mg/ml) induces a transient cortical involution, i.e. inhibition of the cell proliferation and maturation. A: Normal thymus with medulla (1) and cortex (2). B1: Inversion of thymic cortex and medulla 4 to 8 days after CP treatment, i.e. the cortex is lightly stained due to exit of T cells into the medulla without a concomitant supply of new T cells in the cortex. The medulla is stained darkly. B2: Detail of B1 showing a majority of blast-like cells in the cortex and nearly no small T cells, while the medulla (1) contains predominantly small, darkly stained lymphocytes. C: Recovery of the normal situation two weeks later. The CP treatment causes transiently an immunosupression of the antibody response. |
Subtype |
Image |
Format |
image/jpeg |
Collection |
Poja Histology Collection - Lymphatic Tissues and Organs Subset |
ARK |
ark:/87278/s6mk9g4z |
Setname |
ehsl_heal |
ID |
890901 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6mk9g4z |