: Lymph node (human)

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Title : Lymph node (human)
Creator Poels, Lambert G.
Contributor Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen
Date 2010-06-11
Subject paracortex; high endothelial venule (HEV); germinal center
Description Stain: Azan. Specialized venules (1) or so-called high endothelial venules (HEV) are here located in the paracortical area (4) close to the lymphatic follicle (2+3). The HEVs are lined by cuboidal or columnar endothelial cells that possess specific homing receptors for antigen-primed B- and T lymphocytes. The HEV's are the sites of entry of the lymphocytes into the paracortex of the lymph node (lymphocyte homing mechanism), where they leave the blood stream through these HEV and subsequently by diapedesis (--> arrows) between the endothelial cells. B lymphocytes migrate to the lymphatic follicles in the cortex. T lymphocytes remain in the thymus-dependent area of the paracortex. (2) germinal centre in a cortical lymphatic follicle; (3) part of the mantle zone.
Subtype Image
Format image/jpeg
Collection Poja Histology Collection - Lymphatic Tissues and Organs Subset
ARK ark:/87278/s6x380s8
Setname ehsl_heal
Date Created 2012-12-11
Date Modified 2012-12-11
ID 890891
Reference URL https://collections.lib.utah.edu/ark:/87278/s6x380s8