Border of white pulp in spleen (mouse)

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Title Border of white pulp in spleen (mouse)
Creator Poels, Lambert G.
Contributor Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen
Date 2010-06-11
Subject monoamino oxidase; ED3 antibody; follicle; white pulp
Description Monoaminooxidase (enzyme histochemistry on frozen section) with Nitro-BT as staining substrate resulting in a blue formazan precipitate. Despite the general activity of most cells in the spleen, the border cells or so-called metallophilic cells (1) or dendritic antigen-presenting cells (APC) show the most outstanding positive reaction for this oxidative enzyme. These metallophilic macrophages are located strategically for antigen capturing and/or phagocytosis adjacent to the B cells in the follicle. These cells can also be stained positively with anti-CD169 with the antibody ED3. At (2) the faintly negative reacting central artery. (3) indicates the PALS area (T cells) around the arteriole, while (4) points to the germinal centre of the follicle (B cells). The red pulp is marked by (5).
Subtype Image
Format image/jpeg
Collection Poja Histology Collection - Lymphatic Tissues and Organs Subset
ARK ark:/87278/s6sf5zgw
Setname ehsl_heal
Date Created 2012-12-11
Date Modified 2012-12-11
ID 890861
Reference URL https://collections.lib.utah.edu/ark:/87278/s6sf5zgw
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