Keratin 7 staining in squamous metaplasia and dysplasia of the epithelium of a bronchus (human, adult)

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Title Keratin 7 staining in squamous metaplasia and dysplasia of the epithelium of a bronchus (human, adult)
Creator Poels, Lambert G.
Contributor Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen
Date 2006-09-28
Subject Squamous metaplasia; Immunoperoxidase; Immuno-reaction
Description Stain: anti-keratin 7 antibody (Pan-Ck 7) immunoperoxidase staining (with aminoethylcarbazole (AEC) substrate). A red-brown staining with AEC indicates a positive reaction for cytokeratin 7. Note that the top layer only reacts weakly positive for keratin 7 (↓). Upon squamous metaplasia the bronchial epithelial cells largely loose keratin 7 expression. Additionally disturbances in the growth and maturing might result in dysplasia of the epithelium with a changed reaction pattern for cytokeratins. Here it is demonstrated that the basal compartments at the bottom which exhibit very mild dysplasia appear totally negative for keratin 7. This antibody can be useful in the study of premalignant changes in complex epithelia (e.g., pseudostratified, squamous stratified epithelia ).
Subtype Image
Format image/jpeg
Rights http://creativecommons.org/licenses/by-nc-nd/2.5/
Collection Poja Histology Collection - Respiratory System Subset
ARK ark:/87278/s60k5bvm
Setname ehsl_heal
Date Created 2012-12-11
Date Modified 2012-12-11
ID 890751
Reference URL https://collections.lib.utah.edu/ark:/87278/s60k5bvm
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