Applications of microfluidics for molecular diagnostics

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Publication Type journal article
School or College College of Engineering
Department Mechanical Engineering
Research Institute University of Utah
Creator Jayamohan, Harikrishnan
Other Author Sant, Himanshu J., Gale, Bruce K.
Title Applications of microfluidics for molecular diagnostics
Date 2012-11-04
Description Diagnostic assays implemented in microfluidic devices have developed rapidly over the past decade and are expected to become commonplace in the next few years. Hundreds of microfluidics-based approaches towards clinical diagnostics and pathogen detection have been reported with a general theme of rapid and customizable assays that are potentially cost-effective. This chapter reviews microfluidics in molecular diagnostics based on application areas with a concise review of microfluidics in general. Basic principles of microfabrication are briefly reviewed and the transition to polymer fabricated devices is discussed. Most current microfluidic diagnostic devices are designed to target a single disease, such as a given cancer or a variety of pathogens, and there will likely be a large market for these focused devices; however, the future of molecular diagnostics lies in highly multiplexed microfluidic devices that can screen for potentially hundreds of diseases simultaneously.
Type Text
Publisher Springer
Journal Title Methods in Molecular Biology
Volume v. 949
Issue 2013
First Page 305
Last Page 334
DOI 10.1007/978-1-62703-134-9_20.
Subject Microfluidics; Micro-total-analysis-systems; Lab-on-a-chip; Point-of-care devices; Sample preparation; MEMS; Rapid prototyping; Biomarker detection; Personalized medicine; Global health care
Language eng
Bibliographic Citation Jayamohan H1, Sant HJ, Gale BK. Methods in Molecular Biology (2013): Applications of microfluidics for molecular diagnostics
Rights Management (c) Springer; Authors Manuscript; Methods Molecular Biology (2013) ;949:305-34. doi: 10.1007/978-1-62703-134-9_20.
Format Medium application/pdf
Format Extent 33,168,731 Bytes
Identifier uspace, 19386
ARK ark:/87278/s6sv0zzd
Setname ir_uspace
Date Created 2015-04-03
Date Modified 2021-05-06
ID 712914
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