Asymmetrical ventricular enlargement in Parkinsons Disease

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908273/
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Links to Media http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908273/
Publication Type journal article
Creator Gerig, Guido
Other Author Huang, Xuemei.; Lee, Yueh Z.; McKeown, Martin; Gu, Hongbin; Lin, Weili; Lewis, Mechelle M.; Ford, Sutapa; Troster, Alexander I.; Weinberger, Daniel R.; Styner, Martin
Title Asymmetrical ventricular enlargement in Parkinsons Disease
Date 2007-01-01
Description Background-A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson's disease (PD). The current study explored these associations further. Methods-Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healthy Control subjects at baseline and 12-30 months later. Baseline and longitudinal lateral ventricular volumetric changes were compared between contralateral and ipsilateral ventricles in PD subjects relative to symptom onset side and in Controls relative to their dominant hand. Correlations between changes in ventricular volume and United Parkinson's Disease Rating Scale motor scores (UPDRS-III) while on medication were determined. Results-The lateral ventricle contralateral to symptom onset side displayed a faster rate of enlargement compared to the ipsilateral (p=0.004) in PD subjects, with no such asymmetry detected (p=0.312) in Controls. There was a positive correlation between ventricular enlargement and worsening motor function assessed by UPDRS-III scores (r=0.96, p<0.001). Discussion-There is asymmetrical lateral ventricular enlargement that is associated with PD motor asymmetry and progression. Further studies are warranted to investigate the underlying mechanism(s), as well as the potential of using volumetric measurements as a marker for PD progression.
Type InteractiveResource
Publisher Wiley-Blackwell
Journal Title Movement Disorders
Volume 22
Issue 11
First Page 1657
Last Page 1660
DOI 10.1002/mds.21626
Subject Structural magnetic resonance imaging; Semi-automatic segmentation; Lateral ventricular volume; Motor asymmetry; Parkinson's disease
Language eng
Bibliographic Citation Huang, X., Lee, Y. Z., McKeown, M., Gerig, G., Gu, H., Lin, W., Lewis, M. M., Ford, S.,Troster, A. I., Weinberger, D. R., & Styner, M. (2007). Asymmetrical ventricular enlargement in Parkinsons Disease. Movement Disorders, 22(11), 1657-60.
Rights Management (c) Wiley-Blackwell The definitive version is available at www3.interscience.wiley.com ; This is the pre-peer reviewed version of the following article:Huang, X., Lee, Y. Z., McKeown, M., Gerig, G., Gu, H., Lin, W., Lewis, M. M., Ford, S.,Troster, A. I., Weinberger, D. R., & Styner, M. (2007). Asymmetrical ventricular enlargement in Parkinsons Disease. Movement Disorders, 22(11), 1657-60, which has been published in final form at DOI: 10.1002/mds.21626.
Format Medium application/html
Identifier uspace, 19261
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Date Created 2015-04-01
Date Modified 2015-04-01
ID 712905
Reference URL https://collections.lib.utah.edu/ark:/87278/s6zk8rtz
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