Spatio-temporal analysis of early brain development

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Publication Type pre-print
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Creator Gerig, Guido
Other Author Sadeghi, Neda; Prastawa, Marcel; Gilmore, John H.; Lin, Weili
Title Spatio-temporal analysis of early brain development
Date 2010-01-01
Description Analysis of human brain development is a crucial step for improved understanding of neurodevelopmental disorders. We focus on normal brain development as is observed in the multimodal longitudinal MRI/DTI data of neonates to two years of age. We present a spatio-temporal analysis framework using Gompertz function as a population growth model with three different spatial localization strategies: voxel-based, data driven clustering and atlas driven regional analysis. Growth models from multimodal imaging channels collected at each voxel form feature vectors which are clustered using the Dirichlet Process Mixture Models (DPMM). Clustering thus combines growth information from different modalities to subdivide the image into voxel groups with similar properties. The processing generates spatial maps that highlight the dynamic progression of white matter development. These maps show progression of white matter maturation where primarily, central regions mature earlier compared to the periphery, but where more subtle regional differences in growth can be observed. Atlas based analysis allows a quantitative analysis of a specific anatomical region, whereas data driven clustering identifies regions of similar growth patterns. The combination of these two allows us to investigate growth patterns within an anatomical region. Specifically, analysis of anterior and posterior limb of internal capsule show that there are different growth trajectories within these anatomies, and that it may be useful to divide certain anatomies into subregions with distinctive growth patterns.
Type Text
Publisher Institute of Electrical and Electronics Engineers (IEEE)
First Page 777
Last Page 781
Language eng
Bibliographic Citation Sadeghi, N., Prastawa, M., Gilmore, J. H., Lin, W., & Gerig, G. (2010). Spatio-temporal analysis of early brain development. Proceedings IEEE Asilomar Conference on Signals, 777-81.
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Identifier uspace,19213
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Date Created 2015-01-30
Date Modified 2021-05-06
ID 712792
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