Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse

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Publication Type pre-print
School or College <blank>
Department <blank>
Creator Gerig, Guido
Other Author Oguz, Ipek; Gouttard, Sylvain; Lee, Joohwi; An, Hongyu; Lin, Weili; McMurray, Matthew; Grewen, Karen; Johns, Josephine; Styner, Martin Andreas
Title Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse
Date 2011-01-01
Description The use of structural magnetic resonance imaging (sMRI) and diffusion tensor imaging (DTI) in animal models of neurophysiology is of increasing interest to the neuroscience community. In this work, we present our approach to create optimal translational studies that include both animal and human neuroimaging data within the frameworks of a study of post-natal neuro-development in intra-uterine cocaine-exposure. We propose the use of non-invasive neuroimaging to study developmental brain structural and white matter pathway abnormalities via sMRI and DTI, as advanced MR imaging technology is readily available and automated image analysis methodology have recently been transferred from the human to animal imaging setting. For this purpose, we developed a synergistic, parallel approach to imaging and image analysis for the human and the rodent branch of our study. We propose an equivalent design in both the selection of the developmental assessment stage and the neuroimaging setup. This approach brings significant advantages to study neurobiological features of early brain development that are common to animals and humans but also preserve analysis capabilities only possible in animal research. This paper presents the main framework and individual methods for the proposed cross-species study design, as well as preliminary DTI cross-species comparative results in the intra-uterine cocaine-exposure study.
Type Text
Publisher Frontiers Media
Volume 2
Issue 53
First Page 1
Last Page 9
Language eng
Bibliographic Citation Gerig, G., Oguz, I., Gouttard, S., Lee, J., An, H., Lin, W., McMurray, M., Grewen, K., Johns, J., & Styner, M. A. (2011). Synergy of image analysis for animal and human neuroimaging supports translational research on drug abuse. Frontiers in Child and Neurodevelopmental Psychiatry, 2(53), 1-9.
Format Medium application/pdf
Format Extent 876-204 bytes
Identifier uspace,19188
ARK ark:/87278/s6cc48t9
Setname ir_uspace
Date Created 2015-01-24
Date Modified 2015-01-24
ID 712778
Reference URL https://collections.lib.utah.edu/ark:/87278/s6cc48t9
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