Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury

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Publication Type pre-print
School or College <blank>
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Creator Gerig, Guido
Other Author Irimia, Andrei; Chambers, Micah C.; Torgerson, Carinna M.; Filippou, Maria; Hovda, David A.; Alger, Jeffry R.; Toga, Arthur W.; Vespa, Paul M.; Kikinis, Ron; Van Horn, John D.
Title Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury
Date 2012-01-01
Description Available approaches to the investigation of traumatic brain injury (TBI) are frequently hampered, to some extent, by the unsatisfactory abilities of existing methodologies to efficiently define and represent affected structural connectivity and functional mechanisms underlying TI-related pathology. In this paper, we describe a patient-tailored framework which allows mapping and characterization of TBI-related structural damage to the brain via multimodal neuroimaging and personalized connectomics. Specifically, we introduce a graphically driven approach for the assessment of trauma-related atrophy of white matter connections between cortical structures, with relevance to the quantification of TBI chronic case evolution. This approach allows one to inform the formulation of graphical neurophysiology and neurophysiology TBI profiles based on the particular structural deficits of the affected patient. In addition, it allows one to relate the findings supplied by our workflow to the existing body of research that focuses on the functional roles of the cortical structures being targeted. A graphical means for representing patient TBI status is relevant to the emerging field of personalized medicine and to the investigation of neural atrophy.
Type Text
Publisher Frontiers Media
Volume 3
Issue 10
First Page 1
Last Page 21
Language eng
Bibliographic Citation Irimia, A., Chambers, M. C., Torgerson, C. M., Filippou, M., Hovda, D. A., Alger, J. R., Gerig, G., Toga, A. W., Vespa, P. M., Kikinis, R., & Van Horn, J. D. (2012). Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury, Frontiers in Neurotrauma, 3(10), 1-21.
Rights Management (c) Frontiers Media
Format Medium application/pdf
Format Extent 2,447,487 bytes
Identifier uspace,19171
ARK ark:/87278/s6j422pd
Setname ir_uspace
Date Created 2015-01-12
Date Modified 2015-01-12
ID 712769
Reference URL https://collections.lib.utah.edu/ark:/87278/s6j422pd
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