Emerging evidence for platelets as immune and inflammatory effector cells

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Publication Type pre-print
School or College School of Medicine
Department <blank>
Creator Rondina, Matthew Thomas
Other Author Garraud, Olivier
Title Emerging evidence for platelets as immune and inflammatory effector cells
Date 2014-01-01
Description While traditionally recognized for their roles in hemostatic pathways, emerging evidence demonstrates that platelets have previously unrecognized, dynamic roles that span the immune continuum. These newly recognized platelet functions, including the secretion of immune mediators, interactions with endothelial cells, monocytes, and neutrophils, toll-like receptor (TLR) mediated responses, and induction of neutrophil extracellular trap formation, bridge thrombotic and inflammatory pathways and contribute to host defense mechanisms against invading pathogens. In this focused review, we highlight several of these emerging aspects of platelet biology and their implications in clinical infectious syndromes.
Type Text
Publisher Frontiers Media
Volume 653
First Page 1
Last Page 6
Language eng
Bibliographic Citation Rondina, M. T., & Garraud, O. (2014). Emerging evidence for platelets as immune and inflammatory effector cells. Frontiers in Immunology, 5(DEC), 653, 1-6.
Rights Management (c)Frontiers Media
Format Medium application/pdf
Format Extent 1,089,546 bytes
Identifier uspace,19163
ARK ark:/87278/s6sn3k3q
Setname ir_uspace
Date Created 2015-01-12
Date Modified 2015-01-12
ID 712767
Reference URL https://collections.lib.utah.edu/ark:/87278/s6sn3k3q
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