Cytosolic, but not mitochondrial, oxidative stress likely contributes to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice

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Publication Type pre-print
School or College College of Health
Department Nutrition
Creator Jalili, Thunder
Other Author Li, Yan; Wende, Adam R.; Nunthakungwan, Orathai.; Huang, Yujia; Hu, Eric; Jin, Huifeng; Boudina, Sihem; Abel, E. Dale
Title Cytosolic, but not mitochondrial, oxidative stress likely contributes to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice
Date 2012-01-01
Description We hypothesized that oxidative stress may contribute to the development of hypertrophy observed in mice with cardiac specific ablation of the insulin sensitive glucose transporter gene (GLUT4, G4H-/-4 ). Measurements of oxidized glutathione (GSSG) in isolated mitochondria and whole heart homogenates were increased resulting in a lower ratio of reduced glutathione (GSH) to GSSG. Membrane translocation of the p67phox subunit of cardiac NOX2 was markedly increased in G4H-/- mice, suggesting elevated activity.
Type Text
Publisher Wiley-Blackwell
Volume 279
Issue 4
First Page 599
Last Page 611
Language eng
Bibliographic Citation Li, Y., Wende, A. R., Nunthakungwan, O., Huang, Y., Hu, E., Jin, H., Boudina, S., Abel, E. D., & Jalili, T. (2012). Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice. FEBS Journal, 279(4), 599-611.
Rights Management (c) Wiley-Blackwell ; This is the pre-peer reviewed version of the following article: Li, Y., Wende, A. R., Nunthakungwan, O., Huang, Y., Hu, E., Jin, H., Boudina, S., Abel, E. D., & Jalili, T. (2012). Cytosolic, but not mitochondrial, oxidative stress likely contributes to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice. FEBS Journal, 279(4), 599-611., which has been published in final form at doi: 10.1111/j.1742-4658.2011.08450.x.The definitive version is available at www3.interscience.wiley.com
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Identifier uspace,17618
ARK ark:/87278/s67p9h7b
Setname ir_uspace
Date Created 2013-05-22
Date Modified 2013-05-29
ID 708816
Reference URL https://collections.lib.utah.edu/ark:/87278/s67p9h7b
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