A novel human-infection-derived bacterium provides insights into the evolutionary origins of mutualistic insect-bacterial symbioses

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Publication Type pre-print
School or College College of Science
Department Biology
Creator Dale, Colin
Other Author Clayton, Adam L.; Oakeson, Kelly F.; Gutin, Maria; Pontes, Arthur; Dunn, Diane M.; von Niederhausern, Andrew C.; Weiss, Robert B.; Fisher, Mark
Title A novel human-infection-derived bacterium provides insights into the evolutionary origins of mutualistic insect-bacterial symbioses
Date 2012-01-01
Description Despite extensive study, little is known about the origins of the mutualistic bacterial endosymbionts that inhabit approximately 10% of the world's insects. In this study, we characterized a novel opportunistic human pathogen, designated ‘‘strain HS,'' and found that it is a close relative of the insect endosymbiont Sodalis glossinidius. Our results indicate that ancestral relatives of strain HS have served as progenitors for the independent descent of Sodalis-allied endosymbionts found in several insect hosts. Comparative analyses indicate that the gene inventories of the insect endosymbionts were independently derived from a common ancestral template through a combination of irreversible degenerative changes. Our results provide compelling support for the notion that mutualists evolve from pathogenic progenitors. They also elucidate the role of degenerative evolutionary processes in shaping the gene inventories of symbiotic bacteria at a very early stage in these mutualistic associations.
Type Text
Publisher Public Library of Science (PLoS)
Volume 8
Issue 11
First Page 1
Last Page 13
Dissertation Institution University of Utah
Language eng
Bibliographic Citation Clayton, A. L., Oakeson, K. F., Gutin, M., Pontes, A., Dunn, D. M., von Niederhausern, A. C., Weiss, R. B., Fisher, M., & Dale, C. (2012). A novel human-infection-derived bacterium provides insights into the evolutionary origins of mutualistic insect-bacterial symbioses. PLoS Genetics, 8(11), 1-13, no. e1002990.
Rights Management (c) Colin Dale
Format Medium application/pdf
Format Extent 2,395,041 bytes
Identifier uspace,18144
ARK ark:/87278/s6qv458t
Setname ir_uspace
Date Created 2013-01-25
Date Modified 2021-05-06
ID 708307
Reference URL https://collections.lib.utah.edu/ark:/87278/s6qv458t
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