New approaches to bridge nerve gaps: Development of a novel drug-delivering nerve conduit

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Publication Type pre-print
School or College College of Engineering
Department Mechanical Engineering
Creator Gale, Bruce K.
Other Author Lin, Keng-Min; Sant, Himanshu J.; Agarwal, Jayant P.
Title New approaches to bridge nerve gaps: Development of a novel drug-delivering nerve conduit
Date 2012-01-01
Description Contemporary bridging techniques for repairing nerve gaps caused by trauma require autologous nerve grafts, which are difficult to harvest and handle and result in significant donor site deficit. Several nerve conduits with axon growth-enhancing potential have been proposed, developed and tested over the past fifteen years. In this work, prototypes of a nerve conduit designed to bridge large nerve gaps (≥10mm) end-to-end were incorporated with concentric drug reservoirs for constant and controlled drug delivery to enhance axon growth. These devices were designed, fabricated and tested in vitro in amber glass vials with bovine serum albumin in order to determine the drug release kinetics for future application. Our devices have shown the capability to deliver the drug of interest over a 6-day period.
Type Text
Publisher Institute of Electrical and Electronics Engineers (IEEE)
First Page 747
Last Page 750
Dissertation Institution University of Utah
Language eng
Bibliographic Citation Lin, K.-M., Sant, H. J., Gale, B. K., & Agarwal, J. P. (2012). New approaches to bridge nerve gaps: Development of a novel drug-delivering nerve conduit. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, no.6346039, 747-50.
Rights Management (c) 2012 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Format Medium application/pdf
Format Extent 679,690 bytes
Identifier uspace,18135
ARK ark:/87278/s6086q3k
Setname ir_uspace
Date Created 2013-01-25
Date Modified 2013-01-25
ID 708305
Reference URL https://collections.lib.utah.edu/ark:/87278/s6086q3k
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