Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteins

Update item information
Publication Type pre-print
School or College School of Medicine
Department Ophthalmology
Creator Frederick, Jeanne M.
Other Author Constantine, Ryan; Zhang, Houbin; Gerstner, Cecilia D.; Baehr, Wolfgang
Title Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteins
Date 2012-01-01
Description The mechanism by which myristoylated proteins are targeted to specific subcellular membrane compartments is poorly understood. Two novel acyl-binding proteins, UNC119A and UNC119B, have been shown recently to function as chaperones/co-factors in the transport of myristoylated G protein a-subunits and src-type tyrosine kinases. UNC119 polypeptides feature an immunoglobulin-like b-sandwich fold that forms a hydrophobic pocket capable of binding lauroyl (C12) and myristoyl (C14) side chains. UNC119A in rod photoreceptors facilitates the transfer of transducin a subunits (Ta) from inner segment to outer segment membranes by forming an intermediate diffusible UNC119-Ta complex. Similar complexes are formed in other sensory neurons, as the G proteins ODR-3 and GPA-13 in Caenorhabditis elegans unc-119 mutants traffic inappropriately. UNC119B knockdown in IMCD3 cells prevents trafficking of myristoylated nephrocystin-3 (NPHP3), a protein associated with nephronophthisis, to cilia. Further, UNC119A was shown to transport myristoylated src-type tyrosine kinases to cell membranes and to affect T-cell receptor (TCR) and interleukin-5 receptor (IL-5R) activities. These interactions establish UNC119 polypeptides as novel lipid-binding chaperones with specificity for a diverse subset of myristoylated proteins
Type Text
Publisher Elsevier
Dissertation Institution University of Utah
Language eng
Bibliographic Citation Constantine, R., Zhang, H., Gerstner, C. D., Frederick, J. M., & Baehr, W. (2012). Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteins. Vision Research.
Rights Management (c) Elsevier ; Reprinted from Constantine, R., Zhang, H., Gerstner, C. D., Frederick, J. M., & Baehr, W. (2012). Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteins. Vision Research. http://dx.doi.org/DOI: 10.1016/j.visres.2012.08.012.
Format Medium application/pdf
Format Extent 2,103,273 bytes
Identifier uspace,17955
ARK ark:/87278/s6183r9v
Setname ir_uspace
Date Created 2013-01-23
Date Modified 2013-01-24
ID 708297
Reference URL https://collections.lib.utah.edu/ark:/87278/s6183r9v
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