Aberrant functional connectivity of cortico-basal ganglia circuits in major depression

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Publication Type Manuscript
School or College College of Social & Behavioral Science
Department Psychology
Creator Suchy, Yana
Other Author Marchand, William R.; Lee, James N.; Johnson, Susanna; Thatcher, John; Gale, Phillip
Title Aberrant functional connectivity of cortico-basal ganglia circuits in major depression
Date 2012-01-01
Description There is considerable evidence of functional abnormalities of the cortico-basal ganglia circuitry in affective disorders. However, it has been unknown whether this represented primary pathology within these circuits or altered activation as a result of aberrant input from other brain regions. The aim of this study was to test the hypothesis that cortico-basal ganglia circuit dysfunction represents primary pathology in unipolar depression. Eighteen male subjects with recurrent unipolar depression and eighteen controls without psychiatric illness were studied using functional MRI and functional connectivity analyses. All unipolar subjects were unmedicated and without current psychiatric comorbidity. Compared to controls, unipolar subjects exhibited altered connectivity between bilateral subcortical components of the circuitry (putamen-thalamus) and left hemisphere input and output components. Results provided evidence that functional abnormalities of these circuits represent primary pathology. Further, we found that age of onset but not duration of illness impacts circuit function. These findings suggest that the cortico-basal ganglia circuitry is likely one of several loci of primary pathology in major depression. Additionally, early age of onset is associated with greater circuit abnormality and as such may impact clinical characteristics and/or treatment response through a mechanism of decreasing functional connectivity of some circuit segments. Finally, altered cortico-basal ganglia circuit connectivity with cortical regions (anterior cingulate, inferior frontal gyrus and sensorimotor) may contribute to the emotional dysregulation, impaired emotional recognition and psychomotor symptoms associated with unipolar illness.
Type Text
Publisher Elsevier
Volume 514
Issue 1
First Page 86
Last Page 90
DOI http://dx.doi.org/10.1016/j.neulet.2012.02.063
Dissertation Institution University of Utah
Language eng
Bibliographic Citation Marchand, W. R., Lee, J. N., Suchy, Y., Johnson, S., Thatcher, J., & Gale, P. (2012). Aberrant functional connectivity of cortico-basal ganglia circuits in major depression. Neuroscience Letters, 514(1), 86-90.
Rights Management (c) Elsevier ; Reprinted from Marchand, W. R., Lee, J. N., Suchy, Y., Johnson, S., Thatcher, J., & Gale, P. (2012). Aberrant functional connectivity of cortico-basal ganglia circuits in major depression. Neuroscience Letters, 514(1), 86-90.
Format Medium application/pdf
Format Extent 1,037,194 bytes
Identifier uspace,17375
ARK ark:/87278/s6fr0fcf
Setname ir_uspace
Date Created 2012-08-28
Date Modified 2021-05-06
ID 708047
Reference URL https://collections.lib.utah.edu/ark:/87278/s6fr0fcf
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