Anti-tuberculosis IgG antibodies as a marker of active mycobacterium tuberculosis disease

Update item information
Publication Type Manuscript
School or College School of Medicine
Department Pathology
Creator Litwin, Christine M.
Other Author Welch, Ryan J.; Lawless, Kathleen M.
Title Anti-tuberculosis IgG antibodies as a marker of active mycobacterium tuberculosis disease
Date 2012-01-01
Description Anti-Mycobacterium tuberculosis IgG antibodies may aid in the diagnosis of active M. tuberculosis disease. We studied whether anti-M. tuberculosis IgG antibodies are elevated in active M. tuberculosis disease and assessed factors contributing to false positive and negative results. A retrospective study of 2,150 individuals tested by the QuantiFERON-TB Gold In-Tube (QFT-GIT) assay was conducted at University of Utah, ARUP Laboratories, November 2008 to December 2010. All samples were tested with the InBios Active TbDetect™anti-TB IgG antibody assay. Of 1,044 patients with a positive QFT-GIT, 59 (5.7%) were positive for M. tuberculosis antibodies. Fourteen of 1,106 (1.3%) with a negative or indeterminate QFT-GIT were positive for M. tuberculosis antibodies. M. tuberculosis antibody tests were positive in 61.5% with confirmed active M. tuberculosis disease and other mycobacterial infections. Over half of the false negative M. tuberculosis antibody tests occurred in patients ≥ 90 years of age. False positives were seen in 12.9% of autoimmune patients. The odds ratio of being 36 positive on the QFT-GIT and the InBios TB IgG assay increased with confirmed M. tuberculosis disease or highly suspected M. tuberculosis disease and was 86.7 (95% 38 confidence interval [CI], 34.4-218.5) in these two groups when compared to patients negative on both tests. Although anti-M. tuberculosis antibodies can be detected in patients with active M. tuberculosis disease, caution should be used in patients where immunoglobulin levels may be decreased or in patients with autoantibodies.
Type Text
Publisher American Society for Microbiology
Volume 19
Issue 4
First Page 522
Last Page 526
Dissertation Institution University of Utah
Language eng
Bibliographic Citation Welch, R. J., Lawless, K. M., & Litwin, C. M. (2012). Antituberculosis IgG antibodies as a marker of active mycobacterium tuberculosis disease. Clinical and Vaccine Immunology, 19(4), 522-6.
Rights Management (c)American Society for Microbiology
Format Medium application/pdf
Format Extent 1,304,851 bytes
Identifier uspace,17391
ARK ark:/87278/s6q537cq
Setname ir_uspace
Date Created 2012-08-28
Date Modified 2012-08-28
ID 708045
Reference URL https://collections.lib.utah.edu/ark:/87278/s6q537cq
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