SumLINK statistic for linkage analysis: application to the ICPCG pooled linkage resource

Update item information
Publication Type poster
School or College School of Medicine
Department Biomedical Infomatics
Creator Camp, Nicola J.
Other Author Christensen, G. Bryce
Title SumLINK statistic for linkage analysis: application to the ICPCG pooled linkage resource
Date 2009
Description We propose a novel, genome-wide, linkagebased statistic, "sumLINK," for identification of disease susceptibility loci. Our approach focuses primarily on "linked" pedigrees (those with pedigree-specific LOD ? 0.588; equivalent to unadjusted p ? 0.05) to identify regions of extreme consistency across powerful pedigrees. The sumLINK statistic is simply the sum of multipoint LOD scores for linked pedigrees at a given point in the genome. The genetic factors underlying many complex human traits are poorly understood. Linkage findings are often difficult to replicate, and localizing the genes responsible for linkage signals is challenging. We believe that focusing on individually powerful pedigrees may give the greatest opportunity to identify and localize true susceptibility loci and the underlying genes.
Type Text; Image
Publisher University of Utah
Subject SumLINK; Linkage analysis; ICPCG; Disease susceptibility loci; Trapeze Interactive Poster
Subject LCSH Medical genetics; Disease susceptibility -- Genetic aspects
Language eng
Bibliographic Citation Christensen, G. B. & Camp, N. J. (2009). SumLINK statistic for linkage analysis: application to the ICPCG pooled linkage resource. University of Utah.
Rights Management (c)G. Bryce Christensen and Nicola J. Camp
Format Medium application/pdf
Format Extent 159,760 bytes
Identifier ir-main,11059
ARK ark:/87278/s6dz0t2q
Setname ir_uspace
Date Created 2012-07-30
Date Modified 2013-09-25
ID 707829
Reference URL https://collections.lib.utah.edu/ark:/87278/s6dz0t2q
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