Structure of vardenafil in the active site of PDE5

PyMol file (725 KB): http://ir.utah.edu/blumenthal/PyMol/PDE5_Vardenafil.pse Download PyMol software to view this file. Available for free educational use: http://pymol.sourceforge.net Quicktime Movie--High Resolution (4 MB): http://stream.lib.utah.edu/index.php?c=details&id=9288 Quicktime Movie--Medium Resolution (1 MB): http://stream.lib.utah.edu/index.php?c=details&id=9291 iPod (490 KB): http://stream.lib.utah.edu/index.php?c=details&id=9293 The active site of human PDE5 is shown as a ribbon cartoon with key amino acid sidechains and vardenafil represented as stick images (stick coloring is according to element: C = white, N = blue, O = red, S = orange). The zinc (blue-grey) and magnesium (green) ions in the active site are represented as spheres. The amino-terminal cyclin fold domain (residues 537-678) is represented as an orange ribbon, the linker domain (residues 679-725) is represented as a blue ribbon, and the carboxy-terminal helical bundle domain (726-860) is represented as a cyan ribbon. The active site sidechains shown are Tyr612, Tyr664, Val782, Ala783, Phe786, Leu804, Met816, Gln817, and Phe820. The animation is based on the x-ray crystal structure of PDE5 in complex with vardenafil (PDB id:1UHO) and was prepared using PyMol