Genome-wide linkage analysis for aggressive prostate cancer in Utah high risk pedigrees

Update item information
Publication Type poster
School or College School of Medicine
Department Biomedical Infomatics
Creator Camp, Nicola J.
Other Author Christensen, G. B.; Farnham, J. M.; Cannon-Albright, L. A.
Title Genome-wide linkage analysis for aggressive prostate cancer in Utah high risk pedigrees
Date 2009
Description Research has consistently shown that genetics plays a critical role in prostate cancer (CaP) development, but the identification of CaP genes has proven to be very difficult. Hereditary prostate cancer is a complex disease involving numerous genes and variable phenotypic expression. This heterogeneity has led researchers to pursue genes associated with alternative phenotypes for CaP, such as tumor aggressiveness. Several recent linkage studies have used clinical and pathological data to define CaP aggressiveness as a qualitative trait. The International Consortium for Prostate Cancer Genetics (ICPCG) recently completed such an analysis using pooled data from 11 member institutions. This analysis required all families be small to moderate in size in order to facilitate standard linkage analysis software. Hence, although the ICPCG analysis included data from the Utah prostate cancer pedigree resource, the Utah pedigrees were not analyzed in their complete form. Specifically, pedigrees were divided and trimmed before analysis, which reduced the power of the analysis to detect predisposition loci. Here we present the results of a genome-wide scan for aggressive prostate cancer predisposition loci utilizing the full Utah pedigrees.
Type Text; Image
Publisher University of Utah
Subject Linkage analysis; Aggressive prostate cancer; CaP genes; ICPCG; Utah; Trapeze Interactive Poster
Subject LCSH Prostate -- Cancer -- Genetic aspects
Language eng
Bibliographic Citation Christensen, G. B., Camp, N. J., Farnham, J. M., & Cannon-Albright, L. A. (2009). Genome-wide linkage analysis for aggressive prostate cancer in Utah high risk pedigrees.
Rights Management (c)G. B. Christensen, Nicola J. Camp, J. M. Farnham, and L. A. Cannon-Albright
Format Medium application/pdf
Format Extent 115,173 bytes
Identifier ir-main,11052
ARK ark:/87278/s6jm2vb8
Setname ir_uspace
Date Created 2012-07-30
Date Modified 2013-09-25
ID 707673
Reference URL https://collections.lib.utah.edu/ark:/87278/s6jm2vb8
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