Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder

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Publication Type Journal Article
School or College School of Medicine
Department Psychiatry
Creator Sung, Younghoon; Kondo, Douglas Gavin; Jeong, Eun-Kee; Renshaw, Perry Franklin
Other Author Hellem, Tracy L.; Kim, Namkug; Delmastro, Kristen K.; Shi, Xianfeng
Title Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder
Date 2011
Description Introduction. This paper focuses on the application of Magnetic Resonance Spectroscopy (MRS) to the study of Major Depressive Disorder (MDD) in children and adolescents. Method. A literature search using the National Institutes of Health?s PubMed database was conducted to identify indexed peer-reviewed MRS studies in pediatric patients with MDD. Results. The literature search yielded 18 articles reporting original MRS data in pediatric MDD. Neurochemical alterations in Choline, Glutamate, and NAcetyl Aspartate are associated with pediatric MDD, suggesting pathophysiologic continuity with adult MDD. Conclusions. The MRS literature in pediatric MDD is modest but growing. In studies that are methodologically comparable, the results have been consistent. Because it offers a noninvasive and repeatable measurement of relevant in vivo brain chemistry, MRS has the potential to provide insights into the pathophysiology of MDD as well as the mediators and moderators of treatment response.
Type Text
Publisher Hindawi Publishing Corporation
First Page 1
Last Page 13
Language eng
Bibliographic Citation Kondo, D. G., Hellem, T. L., Sung, Y. H., Kim, N., Jeong, E. K., Delmastro, K. K., Shi, X., & Renshaw, P. F. (2011). Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder. Depression Research and Treatment, 1-13.
Rights Management © Author http://creativecommons.org/licenses/by/3.0/legalcode
Format Medium application/pdf
Format Extent 183,281 bytes
Identifier ir-main,16818
ARK ark:/87278/s6kd2gk3
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2021-05-06
ID 707528
Reference URL https://collections.lib.utah.edu/ark:/87278/s6kd2gk3
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