Context-specific memory and apolipoprotein E (ApoE) epsilon 4: cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease.

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Publication Type Journal Article
School or College School of Medicine
Department Neurology
Creator Levy, James A.
Other Author Bergeson, Judy; Putnam, Karen; Rosen, Virginia; Cohen, Robert; Lalonde, Francois; Mirza, Nadeem; Linker, Gary; Sunderland, Trey
Title Context-specific memory and apolipoprotein E (ApoE) epsilon 4: cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease.
Date 2004-05-10
Description The aim of the study was to determine whether the epsilon 4 allele of the apolipoprotein E (ApoE) gene was associated primarily with context-specific memory among individuals at genetic risk for developing Alzheimer's disease. The effect of ApoE status on comprehensive neuropsychological results was examined in 176 healthy adults during baseline cognitive testing in the NIMH Prospective Study of Biomarkers for Older Controls at Risk for Alzheimer's Disease (NIMH Prospective BIOCARD Study). The presence of the epsilon 4 allele was associated with significantly lower total scores on the Logical Memory II subtest of the Wechsler Memory Scale-Revised and percent of information retained after delay. Further analysis indicated the prose recall and retention effect was partially explained by a small subgroup of epsilon 4 homozygotes, suggesting a gradually progressive process that may be presaged with specific cognitive measures. The current results may represent an epsilon 4-associated breakdown between gist-related information and context-bound veridical recall. This relative disconnection may be understood in light of putative epsilon 4-related preclinical accumulation of Alzheimer pathology (tangles and plaques) in the entorhinal cortex (EC) and among frontal networks, as well as the possibility of less-efficient compensatory strategies.
Type Text
Publisher Cambridge
Volume 10
Issue 3
First Page 362
Last Page 370
Subject Alleles; Apolipoprotein E4; Mental Status Schedule
Subject MESH Alzheimer Disease; Apolipoproteins E; Memory
Language eng
Bibliographic Citation J Int Neuropsychol Soc. 2004 May;10(3):362-70. Levy JA, Bergeson J; Putnam K; Rosen V; Cohen R; Lalonde F, Mirza N, Linker G, Sunderland T. Context-specific memory and apolipoprotein E (ApoE) epsilon 4: cognitive evidence from the NIMH prospective study of risk for Alzheimer's disease.
Rights Management Copyright © 2004 Cambridge. All righs reserved.
Format Medium application/pdf
Identifier ir-main,825
ARK ark:/87278/s61r7845
Setname ir_uspace
Date Created 2012-06-13
Date Modified 2012-06-13
ID 707270
Reference URL https://collections.lib.utah.edu/ark:/87278/s61r7845
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